The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans
We report the isolation and extensive analysis of highly polymorphic MHC class I genes from sharks (Triakis scyllia), which belong to the most primitive vertebrate group with jaws, the cartilaginous fish. Predicted complete peptide-binding domains showed retention of the critical amino acid residues...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 1997-12, Vol.7 (6), p.777-790 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Okamura, K Ototake, M Nakanishi, T Kurosawa, Y Hashimoto, K |
| description | We report the isolation and extensive analysis of highly polymorphic MHC class I genes from sharks (Triakis scyllia), which belong to the most primitive vertebrate group with jaws, the cartilaginous fish. Predicted complete peptide-binding domains showed retention of the critical amino acid residues that would interact with antigenic peptide termini and revealed extensive allelic polymorphisms comparable to those of classic human MHC class I molecules. Mosaic structures were apparent in these domains, suggesting recombinational mechanisms to create allelic diversity. The present study demonstrates the establishment of the basic strategy for antigen-presentation employed by MHC class I molecules and documents complete divergence of two polymorphic MHC classes at a phylogenetically primitive stage of vertebrate evolution. |
| doi_str_mv | 10.1016/S1074-7613(00)80396-9 |
| format | Article |
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Predicted complete peptide-binding domains showed retention of the critical amino acid residues that would interact with antigenic peptide termini and revealed extensive allelic polymorphisms comparable to those of classic human MHC class I molecules. Mosaic structures were apparent in these domains, suggesting recombinational mechanisms to create allelic diversity. 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| ispartof | Immunity (Cambridge, Mass.), 1997-12, Vol.7 (6), p.777-790 |
| issn | 1074-7613 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Alleles Amino Acid Sequence Animals Base Sequence Blotting, Southern Chromosome Mapping DNA, Complementary Genes, MHC Class I Humans Jaw Molecular Sequence Data Mosaicism Polymorphism, Genetic Recombination, Genetic Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Sharks - genetics Sharks - immunology Species Specificity |
| title | The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans |
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