Adrenomedullin has mitogenic effects on human oral keratinocytes: involvement of cyclic AMP

The effects of the novel vasoactive regulatory peptide, adrenomedullin, on human oral keratinocytes was investigated. Adrenomedullin, acting via its specific receptor, stimulated a dose-dependent increase in DNA synthesis, and, in addition, stimulated further changes in the cell cycle resulting in t...

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Veröffentlicht in:	FEBS letters 1997-12, Vol.418 (3), p.287-290
Hauptverfasser:	Kapas, Supriya, Brown, Dean W, Farthing, Paula M, Hagi-Pavli, Eleni
Format:	Artikel
Sprache:	eng
Schlagworte:	3-isobutyl-1-methylxanthine Adrenomedullin calcitonin gene-related peptide cAMP Cell Division - drug effects Cells, Cultured CGRP cyclic adenosine monophosphate Cyclic AMP Cyclic AMP - metabolism dbcAMP di-butyryl cAMP human umbilical vein endothelial cells Humans HUVEC IBMX Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Mitogenesis Mouth - cytology Oral keratinocyte PBS Peptides - pharmacology phosphate buffered saline PKC protein kinase C Signal Transduction - drug effects
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