Use of transgenic mice in lipoprotein metabolism and atherosclerosis research
In apoe★3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of apoe 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age an...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1997-10, Vol.57 (4), p.463-466 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Havekes, L.M. van Vlijmen, B.J.M. Jong, M.C. van Dijk, K.W. Hofker, M.H. |
| description | In
apoe★3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of
apoe 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride. |
| doi_str_mv | 10.1016/S0952-3278(97)90429-4 |
| format | Article |
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apoe★3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of
apoe 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/S0952-3278(97)90429-4</identifier><identifier>PMID: 9430397</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Age Factors ; Animals ; Apolipoprotein E3 ; Apolipoproteins C - metabolism ; Apolipoproteins E - deficiency ; Arteriosclerosis - metabolism ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cholesterol - blood ; Female ; Humans ; Lipids - blood ; Lipoproteins - metabolism ; Lipoproteins, VLDL - metabolism ; Male ; Medical sciences ; Mice ; Mice, Transgenic - genetics ; Mice, Transgenic - metabolism ; Sex Factors</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 1997-10, Vol.57 (4), p.463-466</ispartof><rights>1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-f99e5b132d9162257ac98f082220d759d19caa6d2ef95d0daae96779f48dfe363</citedby><cites>FETCH-LOGICAL-c389t-f99e5b132d9162257ac98f082220d759d19caa6d2ef95d0daae96779f48dfe363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0952-3278(97)90429-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2122971$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9430397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Havekes, L.M.</creatorcontrib><creatorcontrib>van Vlijmen, B.J.M.</creatorcontrib><creatorcontrib>Jong, M.C.</creatorcontrib><creatorcontrib>van Dijk, K.W.</creatorcontrib><creatorcontrib>Hofker, M.H.</creatorcontrib><title>Use of transgenic mice in lipoprotein metabolism and atherosclerosis research</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>In
apoe★3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of
apoe 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Apolipoprotein E3</subject><subject>Apolipoproteins C - metabolism</subject><subject>Apolipoproteins E - deficiency</subject><subject>Arteriosclerosis - metabolism</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. 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apoe★3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of
apoe 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>9430397</pmid><doi>10.1016/S0952-3278(97)90429-4</doi><tpages>4</tpages></addata></record> |
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| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 1997-10, Vol.57 (4), p.463-466 |
| issn | 0952-3278 1532-2823 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Age Factors Animals Apolipoprotein E3 Apolipoproteins C - metabolism Apolipoproteins E - deficiency Arteriosclerosis - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol - blood Female Humans Lipids - blood Lipoproteins - metabolism Lipoproteins, VLDL - metabolism Male Medical sciences Mice Mice, Transgenic - genetics Mice, Transgenic - metabolism Sex Factors |
| title | Use of transgenic mice in lipoprotein metabolism and atherosclerosis research |
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