Stereoselective Reduction of Acetohexamide in Cytosol of Rabbit Liver

The stereoselective reduction of acetohexamide, an oral antidiabetic drug, was studied by using the cytosol of rabbit liver. A major metabolite of acetohexamide was isolated in 41.5% yield from the enzyme reaction mixture, and identified as (-)-hydroxyhexamide by techniques including the melting poi...

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Veröffentlicht in:	Journal of Pharmacobio-Dynamics 1989, Vol.12(12), pp.731-735
Hauptverfasser:	IMAMURA, Yorishige, KOJIMA, Yuichiro, HIGUCHI, Toshiyuki, AKITA, Hiroyuki, OISHI, Takeshi, OTAGIRI, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	1H-NMR spectrum Acetohexamide - analogs & derivatives Acetohexamide - isolation & purification Acetohexamide - metabolism Alcohol Oxidoreductases - metabolism Animals Biological and medical sciences Chromatography, Ion Exchange Cytosol - enzymology Cytosol - metabolism General and cellular metabolism. Vitamins Liver - enzymology Liver - ultrastructure Magnetic Resonance Spectroscopy Male Medical sciences Oxidation-Reduction Pharmacology. Drug treatments Rabbits Stereoisomerism
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