Eicosanoids mediate induction of immune genes in the fat body of the silkworm, Bombyx mori
The expression of cecropin and lysozyme genes is induced in response to bacterial peptidoglycan in the fat body of the silkworm, Bombyx mori. Specific inhibitors of either phospholipase A 2, cyclooxygenase or lipoxygenase significantly inhibit the induction of the immune genes both in vivo and in cu...
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| Veröffentlicht in: | FEBS letters 1997-12, Vol.419 (1), p.83-86 |
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| creator | Morishima, Isao Yamano, Yoshiaki Inoue, Kenji Matsuo, Noriyuki |
| description | The expression of cecropin and lysozyme genes is induced in response to bacterial peptidoglycan in the fat body of the silkworm,
Bombyx mori. Specific inhibitors of either phospholipase A
2, cyclooxygenase or lipoxygenase significantly inhibit the induction of the immune genes both in vivo and in cultured fat body as detected by means of Northern hybridization. Arachidonic acid injected into the larvae induces the expression of the cecropin and lysozyme genes. The findings support the idea that eicosanoids mediate some process leading to the expression of immune genes in the fat body following recognition of peptidoglycan as a signal for invading bacteria. |
| doi_str_mv | 10.1016/S0014-5793(97)01418-X |
| format | Article |
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Bombyx mori. Specific inhibitors of either phospholipase A
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Bombyx mori. Specific inhibitors of either phospholipase A
2, cyclooxygenase or lipoxygenase significantly inhibit the induction of the immune genes both in vivo and in cultured fat body as detected by means of Northern hybridization. Arachidonic acid injected into the larvae induces the expression of the cecropin and lysozyme genes. The findings support the idea that eicosanoids mediate some process leading to the expression of immune genes in the fat body following recognition of peptidoglycan as a signal for invading bacteria.</description><subject>Animals</subject><subject>Arachidonic Acid - pharmacology</subject><subject>Bombyx - genetics</subject><subject>Bombyx - immunology</subject><subject>BPB</subject><subject>Cecropin</subject><subject>Culture Techniques</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>dimethyl sulfoxide</subject><subject>DMSO</subject><subject>Eicosanoid</subject><subject>Eicosanoids - biosynthesis</subject><subject>Eicosanoids - physiology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fat Body - immunology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - immunology</subject><subject>Genes, Insect - immunology</subject><subject>Insect immunity</subject><subject>Insect Proteins - genetics</subject><subject>Lipoxygenase Inhibitors - pharmacology</subject><subject>Lysozyme</subject><subject>Muramidase - genetics</subject><subject>NDGA</subject><subject>nordihydroguaiaretic acid</subject><subject>p-bromophenacylbromide</subject><subject>Peptidoglycan</subject><subject>Peptidoglycan - pharmacology</subject><subject>phospholipase A2</subject><subject>Phospholipases A - antagonists & inhibitors</subject><subject>Phospholipases A2</subject><subject>PLA2</subject><subject>RNA, Messenger - analysis</subject><subject>Silkworm</subject><subject>soluble peptidoglycan</subject><subject>SPG</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P2zAYx61pE5Syj4DkE9okAnH8lpzQisqKhMRhQ6p2sWL7yfCWxGAnQL_9nLbiyk724__LY_0QOiH5OcmJuPiR54RlXFb0SyW_pjsps_UHNCOlpBllovyIZm-WQ3QU4588zSWpDtBBxQpRFGyGfi2d8bHuvbMRd2BdPQB2vR3N4HyPfYNd14094N_QQ0wKHh4AN_WAtbebSZ_m6Nq_Lz50Z3jhO715xZ0P7hh9auo2wuf9OUf318ufV6vs9u77zdW328xwztcZY0RIw0stamY05dAwSwrgOdUE8sYKrXVjK7BWS1nxQhDREGZNrZkBSy2do9Nd72PwTyPEQXUuGmjbugc_RpVChHPJ3zUSUUhKC5GMfGc0wccYoFGPwXV12CiSqwm-2sJXE1lVSbWFr9Ypd7JfMOrE8i21p5301U5_cS1s_q9UXS8XxVaZhEpun6dVl7sqSGSfHQQVjYM-EXEBzKCsd-989h9Plalr</recordid><startdate>19971208</startdate><enddate>19971208</enddate><creator>Morishima, Isao</creator><creator>Yamano, Yoshiaki</creator><creator>Inoue, Kenji</creator><creator>Matsuo, Noriyuki</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19971208</creationdate><title>Eicosanoids mediate induction of immune genes in the fat body of the silkworm, Bombyx mori</title><author>Morishima, Isao ; Yamano, Yoshiaki ; Inoue, Kenji ; Matsuo, Noriyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555X-44167c58b6a4cb35ef4d12e503b1e0fd6bbbfd9eddb77952616f14dcab4ced3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Arachidonic Acid - pharmacology</topic><topic>Bombyx - genetics</topic><topic>Bombyx - immunology</topic><topic>BPB</topic><topic>Cecropin</topic><topic>Culture Techniques</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>dimethyl sulfoxide</topic><topic>DMSO</topic><topic>Eicosanoid</topic><topic>Eicosanoids - biosynthesis</topic><topic>Eicosanoids - physiology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fat Body - immunology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - immunology</topic><topic>Genes, Insect - immunology</topic><topic>Insect immunity</topic><topic>Insect Proteins - genetics</topic><topic>Lipoxygenase Inhibitors - pharmacology</topic><topic>Lysozyme</topic><topic>Muramidase - genetics</topic><topic>NDGA</topic><topic>nordihydroguaiaretic acid</topic><topic>p-bromophenacylbromide</topic><topic>Peptidoglycan</topic><topic>Peptidoglycan - pharmacology</topic><topic>phospholipase A2</topic><topic>Phospholipases A - antagonists & inhibitors</topic><topic>Phospholipases A2</topic><topic>PLA2</topic><topic>RNA, Messenger - analysis</topic><topic>Silkworm</topic><topic>soluble peptidoglycan</topic><topic>SPG</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morishima, Isao</creatorcontrib><creatorcontrib>Yamano, Yoshiaki</creatorcontrib><creatorcontrib>Inoue, Kenji</creatorcontrib><creatorcontrib>Matsuo, Noriyuki</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morishima, Isao</au><au>Yamano, Yoshiaki</au><au>Inoue, Kenji</au><au>Matsuo, Noriyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eicosanoids mediate induction of immune genes in the fat body of the silkworm, Bombyx mori</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1997-12-08</date><risdate>1997</risdate><volume>419</volume><issue>1</issue><spage>83</spage><epage>86</epage><pages>83-86</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The expression of cecropin and lysozyme genes is induced in response to bacterial peptidoglycan in the fat body of the silkworm,
Bombyx mori. Specific inhibitors of either phospholipase A
2, cyclooxygenase or lipoxygenase significantly inhibit the induction of the immune genes both in vivo and in cultured fat body as detected by means of Northern hybridization. Arachidonic acid injected into the larvae induces the expression of the cecropin and lysozyme genes. The findings support the idea that eicosanoids mediate some process leading to the expression of immune genes in the fat body following recognition of peptidoglycan as a signal for invading bacteria.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>9426224</pmid><doi>10.1016/S0014-5793(97)01418-X</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Arachidonic Acid - pharmacology Bombyx - genetics Bombyx - immunology BPB Cecropin Culture Techniques Cyclooxygenase Inhibitors - pharmacology dimethyl sulfoxide DMSO Eicosanoid Eicosanoids - biosynthesis Eicosanoids - physiology Enzyme Inhibitors - pharmacology Fat Body - immunology Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Genes, Insect - immunology Insect immunity Insect Proteins - genetics Lipoxygenase Inhibitors - pharmacology Lysozyme Muramidase - genetics NDGA nordihydroguaiaretic acid p-bromophenacylbromide Peptidoglycan Peptidoglycan - pharmacology phospholipase A2 Phospholipases A - antagonists & inhibitors Phospholipases A2 PLA2 RNA, Messenger - analysis Silkworm soluble peptidoglycan SPG |
| title | Eicosanoids mediate induction of immune genes in the fat body of the silkworm, Bombyx mori |
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