Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: Extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity
Since its introduction into the statistical genetics literature, the transmission disequilibrium test (TDT) has seen widespread use in analyses of linkage and association due not only to its simplicity but also to its desirable properties relative to other within‐family analytic methods. In this pap...
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| Veröffentlicht in: | Genetic epidemiology 1997, Vol.14 (6), p.699-704 |
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| creator | Waldman, Irwin D. Robinson, Byron F. Feigon, Sarah A. |
| description | Since its introduction into the statistical genetics literature, the transmission disequilibrium test (TDT) has seen widespread use in analyses of linkage and association due not only to its simplicity but also to its desirable properties relative to other within‐family analytic methods. In this paper, we describe an extension to the TDT useful for examining genetic heterogeneity. This extension uses contingency table analyses such as log‐linear analysis to test for differences in linkage disequilibrium across levels of one or more moderator variables. We applied these analyses to test for linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder, as well as for genetic heterogeneity due to sex, diagnostic breadth, and study site. Using data from two studies (the UCSD/UBC and Cardiff data sets), we found evidence suggesting linkage disequilibrium between DAT1 and bipolar disorder, as well as heterogeneity due to diagnostic breadth and study site. © 1997 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1098-2272(1997)14:6<699::AID-GEPI25>3.0.CO;2-K |
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Epidemiol</addtitle><description>Since its introduction into the statistical genetics literature, the transmission disequilibrium test (TDT) has seen widespread use in analyses of linkage and association due not only to its simplicity but also to its desirable properties relative to other within‐family analytic methods. In this paper, we describe an extension to the TDT useful for examining genetic heterogeneity. This extension uses contingency table analyses such as log‐linear analysis to test for differences in linkage disequilibrium across levels of one or more moderator variables. We applied these analyses to test for linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder, as well as for genetic heterogeneity due to sex, diagnostic breadth, and study site. 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Epidemiol</addtitle><date>1997</date><risdate>1997</risdate><volume>14</volume><issue>6</issue><spage>699</spage><epage>704</epage><pages>699-704</pages><issn>0741-0395</issn><eissn>1098-2272</eissn><abstract>Since its introduction into the statistical genetics literature, the transmission disequilibrium test (TDT) has seen widespread use in analyses of linkage and association due not only to its simplicity but also to its desirable properties relative to other within‐family analytic methods. In this paper, we describe an extension to the TDT useful for examining genetic heterogeneity. This extension uses contingency table analyses such as log‐linear analysis to test for differences in linkage disequilibrium across levels of one or more moderator variables. We applied these analyses to test for linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder, as well as for genetic heterogeneity due to sex, diagnostic breadth, and study site. 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| ispartof | Genetic epidemiology, 1997, Vol.14 (6), p.699-704 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alleles association Bipolar Disorder - genetics Carrier Proteins - genetics Dopamine Plasma Membrane Transport Proteins Female Genetic Heterogeneity Genotype Heterozygote Humans linkage Linkage Disequilibrium log-linear analysis Logistic Models Male Membrane Glycoproteins Membrane Transport Proteins Minisatellite Repeats Models, Genetic moderators Nerve Tissue Proteins Nuclear Family Polymerase Chain Reaction Risk Factors TDT |
| title | Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: Extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity |
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