Synthesis of 6-Methyl[ 11C]-2′-deoxyuridine and evaluation of Its In Vivo distribution in Wistar rats

In this study, 6-methyl-2′-deoxyuridine, an artificial nucleoside, was labeled with 11C in the methyl position. Tissue distribution of 6-methyl[ 11C]-2′-deoxyuridine was investigated in normal Wistar rats and compared to the behavior of the natural nucleoside [methyl- 11C]thymidine. High renal clear...

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Veröffentlicht in:	Nuclear medicine and biology 1997-11, Vol.24 (8), p.713-718
Hauptverfasser:	Goethals, Patrick, Volders, Filip, Van der Eycken, Johan, van Eijkeren, Marc, Lemahieu, Ignace, Dams, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	6-M[ 11C]UdR 6-Methyl[ 11C]-2′-deoxyuridine [methyl- 11C]TdR [methyl- 11C]thymidine Animals Biological and medical sciences Carbon Radioisotopes - chemistry Cell proliferation Chromatography, High Pressure Liquid Contrast media. Radiopharmaceuticals Deoxyuridine - analogs & derivatives Deoxyuridine - chemical synthesis Deoxyuridine - pharmacokinetics Isotope Labeling - methods Male Medical sciences Pharmacology. Drug treatments Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Synthesis Thymidine - analogs & derivatives Thymidine - pharmacokinetics Tissue Distribution Tomography, Emission-Computed
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