Inhibition of HIV-1 reverse transcriptase by 5′-triphosphates of 5-substituted uridine analogs

The 5′-triphosphates of some 5-substituted 2′-deoxyuridine analogs were investigated for their effects on purified recombinant reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) as well as cellular DNA polymerase α. The triphosphates were competitive inhibitors of the viral enzyme...

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Veröffentlicht in:	Antiviral research 1989-12, Vol.12 (5), p.269-278
Hauptverfasser:	Tao, Pei-Zhen, Johansson, Nils Gunnar, Stening, Göran, Öberg, Bo, Datema, Roelf
Format:	Artikel
Sprache:	eng
Schlagworte:	Action of physical and chemical agents AIDS/HIV Antiviral Agents - pharmacology Biological and medical sciences Chemotherapy DNA Polymerase II - antagonists & inhibitors DNA, Viral - biosynthesis Drug Design Fundamental and applied biological sciences. Psychology HIV-1 - drug effects HIV-1 - enzymology Human immunodeficiency virus Kinetics Microbiology Nucleoside analog Reverse transcriptase Reverse Transcriptase Inhibitors Templates, Genetic Thymine Nucleotides - metabolism Uridine Triphosphate - analogs & derivatives Uridine Triphosphate - pharmacology Virology Zidovudine - pharmacology
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