Outcome of chickenpox in 66 pediatric renal transplant recipients
Although chickenpox can cause severe morbidity and mortality in pediatric renal transplant recipients, published reports describing treatment of these patients are few, especially in the cyclosporine era. Sixty-nine episodes of chickenpox occurring in 66 patients were diagnosed in our transplant pop...
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| Veröffentlicht in: | The Journal of pediatrics 1997-12, Vol.131 (6), p.874-877 |
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| container_title | The Journal of pediatrics |
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| creator | Kashtan, Clifford E. Cook, Marie Chavers, Blanche M. Mauer, S.Michael Nevins, Thomas E. |
| description | Although chickenpox can cause severe morbidity and mortality in pediatric renal transplant recipients, published reports describing treatment of these patients are few, especially in the cyclosporine era. Sixty-nine episodes of chickenpox occurring in 66 patients were diagnosed in our transplant population between January 1984 and May 1996. Immunosuppression consisted of prednisone and azathioprine (30 cases); prednisone, azathioprine, and cyclosporine (38 cases); or prednisone alone (1 case). Azathioprine was temporarily discontinued in 66 of 68 cases. Cyclosporine was continued at the preexisting dose in 36 of 38 cases. Acyclovir was administered parenterally in 62 of 69 cases. Sixty-five of 66 patients survived. Cyclosporine use did not increase the incidence of severe disease (
p > 0.1). Acute allograft rejection occurred in three patients and responded to prednisone. Chickenpox in children with renal transplants can be successfully treated with intravenous acyclovir and temporary withdrawal of azathioprine. Allograft rejection is uncommon with this approach. Patients receiving cyclosporine do not appear to experience increased morbidity or mortality with chickenpox. (J Pediatr 1997;131:874-7) |
| doi_str_mv | 10.1016/S0022-3476(97)70036-2 |
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p > 0.1). Acute allograft rejection occurred in three patients and responded to prednisone. Chickenpox in children with renal transplants can be successfully treated with intravenous acyclovir and temporary withdrawal of azathioprine. Allograft rejection is uncommon with this approach. Patients receiving cyclosporine do not appear to experience increased morbidity or mortality with chickenpox. (J Pediatr 1997;131:874-7)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(97)70036-2</identifier><identifier>PMID: 9427893</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Acyclovir - administration & dosage ; Administration, Oral ; Adolescent ; Azathioprine - administration & dosage ; Biological and medical sciences ; Chickenpox - drug therapy ; Chickenpox - mortality ; Child ; Cyclosporine - administration & dosage ; Drug Therapy, Combination ; Graft Rejection - epidemiology ; Human viral diseases ; Humans ; Immunosuppression ; Incidence ; Infectious diseases ; Injections, Intravenous ; Kidney Transplantation ; Medical sciences ; Prednisone - administration & dosage ; Retrospective Studies ; Survival Rate ; Treatment Outcome ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>The Journal of pediatrics, 1997-12, Vol.131 (6), p.874-877</ispartof><rights>1997 Mosby, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-a93ebd09cda1b6a192f45f0777a4db7941d51d7c22534b30607892b85f0e81a53</citedby><cites>FETCH-LOGICAL-c455t-a93ebd09cda1b6a192f45f0777a4db7941d51d7c22534b30607892b85f0e81a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(97)70036-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2113062$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9427893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kashtan, Clifford E.</creatorcontrib><creatorcontrib>Cook, Marie</creatorcontrib><creatorcontrib>Chavers, Blanche M.</creatorcontrib><creatorcontrib>Mauer, S.Michael</creatorcontrib><creatorcontrib>Nevins, Thomas E.</creatorcontrib><title>Outcome of chickenpox in 66 pediatric renal transplant recipients</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Although chickenpox can cause severe morbidity and mortality in pediatric renal transplant recipients, published reports describing treatment of these patients are few, especially in the cyclosporine era. Sixty-nine episodes of chickenpox occurring in 66 patients were diagnosed in our transplant population between January 1984 and May 1996. Immunosuppression consisted of prednisone and azathioprine (30 cases); prednisone, azathioprine, and cyclosporine (38 cases); or prednisone alone (1 case). Azathioprine was temporarily discontinued in 66 of 68 cases. Cyclosporine was continued at the preexisting dose in 36 of 38 cases. Acyclovir was administered parenterally in 62 of 69 cases. Sixty-five of 66 patients survived. Cyclosporine use did not increase the incidence of severe disease (
p > 0.1). Acute allograft rejection occurred in three patients and responded to prednisone. Chickenpox in children with renal transplants can be successfully treated with intravenous acyclovir and temporary withdrawal of azathioprine. Allograft rejection is uncommon with this approach. Patients receiving cyclosporine do not appear to experience increased morbidity or mortality with chickenpox. (J Pediatr 1997;131:874-7)</description><subject>Acyclovir - administration & dosage</subject><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Azathioprine - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Chickenpox - drug therapy</subject><subject>Chickenpox - mortality</subject><subject>Child</subject><subject>Cyclosporine - administration & dosage</subject><subject>Drug Therapy, Combination</subject><subject>Graft Rejection - epidemiology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Injections, Intravenous</subject><subject>Kidney Transplantation</subject><subject>Medical sciences</subject><subject>Prednisone - administration & dosage</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6E4QeRPRQnSRN0pxkWfyChT2o55CmKUa7bU1a0X9vdrfs1dPAzDMzLw9C5xhuMGB--wJASEozwa-kuBYAlKfkAE0xSJHynNJDNN0jx-gkhA8AkBnABE1kRkQu6RTNV0Nv2rVN2iox78582qZrfxLXJJwnnS2d7r0zibeNrpPe6yZ0tW762DCuc7bpwyk6qnQd7NlYZ-jt4f518ZQuV4_Pi_kyNRljfaoltUUJ0pQaF1xjSaqMVSCE0FlZCJnhkuFSGEIYzQoKHGJAUuSRsTnWjM7Q5e5u59uvwYZerV0wto5xbDsEJSQDjlkeQbYDjW9D8LZSnXdr7X8VBrVRp7bq1MaLkkJt1SkS987HB0OxtuV-a3QV5xfjXAej6yrKMC7sMYJxTL05c7fDbJTx7axXwURRJrqM0npVtu6fIH-P8Il4</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Kashtan, Clifford E.</creator><creator>Cook, Marie</creator><creator>Chavers, Blanche M.</creator><creator>Mauer, S.Michael</creator><creator>Nevins, Thomas E.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>Outcome of chickenpox in 66 pediatric renal transplant recipients</title><author>Kashtan, Clifford E. ; Cook, Marie ; Chavers, Blanche M. ; Mauer, S.Michael ; Nevins, Thomas E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-a93ebd09cda1b6a192f45f0777a4db7941d51d7c22534b30607892b85f0e81a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acyclovir - administration & dosage</topic><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Azathioprine - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Chickenpox - drug therapy</topic><topic>Chickenpox - mortality</topic><topic>Child</topic><topic>Cyclosporine - administration & dosage</topic><topic>Drug Therapy, Combination</topic><topic>Graft Rejection - epidemiology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunosuppression</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Injections, Intravenous</topic><topic>Kidney Transplantation</topic><topic>Medical sciences</topic><topic>Prednisone - administration & dosage</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashtan, Clifford E.</creatorcontrib><creatorcontrib>Cook, Marie</creatorcontrib><creatorcontrib>Chavers, Blanche M.</creatorcontrib><creatorcontrib>Mauer, S.Michael</creatorcontrib><creatorcontrib>Nevins, Thomas E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kashtan, Clifford E.</au><au>Cook, Marie</au><au>Chavers, Blanche M.</au><au>Mauer, S.Michael</au><au>Nevins, Thomas E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome of chickenpox in 66 pediatric renal transplant recipients</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>131</volume><issue>6</issue><spage>874</spage><epage>877</epage><pages>874-877</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Although chickenpox can cause severe morbidity and mortality in pediatric renal transplant recipients, published reports describing treatment of these patients are few, especially in the cyclosporine era. Sixty-nine episodes of chickenpox occurring in 66 patients were diagnosed in our transplant population between January 1984 and May 1996. Immunosuppression consisted of prednisone and azathioprine (30 cases); prednisone, azathioprine, and cyclosporine (38 cases); or prednisone alone (1 case). Azathioprine was temporarily discontinued in 66 of 68 cases. Cyclosporine was continued at the preexisting dose in 36 of 38 cases. Acyclovir was administered parenterally in 62 of 69 cases. Sixty-five of 66 patients survived. Cyclosporine use did not increase the incidence of severe disease (
p > 0.1). Acute allograft rejection occurred in three patients and responded to prednisone. Chickenpox in children with renal transplants can be successfully treated with intravenous acyclovir and temporary withdrawal of azathioprine. Allograft rejection is uncommon with this approach. Patients receiving cyclosporine do not appear to experience increased morbidity or mortality with chickenpox. (J Pediatr 1997;131:874-7)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9427893</pmid><doi>10.1016/S0022-3476(97)70036-2</doi><tpages>4</tpages></addata></record> |
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| subjects | Acyclovir - administration & dosage Administration, Oral Adolescent Azathioprine - administration & dosage Biological and medical sciences Chickenpox - drug therapy Chickenpox - mortality Child Cyclosporine - administration & dosage Drug Therapy, Combination Graft Rejection - epidemiology Human viral diseases Humans Immunosuppression Incidence Infectious diseases Injections, Intravenous Kidney Transplantation Medical sciences Prednisone - administration & dosage Retrospective Studies Survival Rate Treatment Outcome Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | Outcome of chickenpox in 66 pediatric renal transplant recipients |
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