Evaluation of a no-needle penile injector: a preliminary study evaluating tissue penetration and its hemodynamic consequences in the rat
Intracavernous needle injection is an effective delivery method for pharmacotherapy of erectile dysfunction. Needle phobia, pain, and concern about local tissue injury have stimulated the search for new, less invasive means of inducing penile erection. In this preliminary communication, we evaluate...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 1997-12, Vol.50 (6), p.994-998 |
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| container_title | Urology (Ridgewood, N.J.) |
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| creator | Seyam, Raouf M. Bégin, Louis R. Tu, Le Mai Dion, Stéphane B. Merlin, Scott L. Brock, Gerald B. |
| description | Intracavernous needle injection is an effective delivery method for pharmacotherapy of erectile dysfunction. Needle phobia, pain, and concern about local tissue injury have stimulated the search for new, less invasive means of inducing penile erection. In this preliminary communication, we evaluate a jet injector as an alternative to needle injection for intracavernous delivery of vasoactive drugs.
Jet injection was evaluated in three groups of rats receiving either India ink, saline, or papaverine into the penis. The ability of the jet injection to penetrate through the tunica albuginea and deliver liquid to the corpora cavernosa smooth muscle was assessed by the degree of staining within the corpus cavernosum (ink group), histologic change (saline group), and rise in intracavernous pressure (papaverine group). Erectile capacity following cavernous nerve electric stimulation was compared before and 1 hour after injection of saline or papaverine.
Ink traversed the skin and tunica albuginea with extensive deposition noted within the cavernous spaces. Varying degrees of subcutaneous hemorrhage were seen with saline jet injection; however, the corpus cavernous smooth muscles showed no evidence of injury. Jet injection of papaverine 3250
gmg significantly increased cavernous pressure (39.4 ± 4.6 cm H
2O) compared with saline injection (2.8 ± 1.3 cm H
2O).
We conclude that acute jet injection is an effective method for intracavernous delivery of drugs. Long-term effects should be evaluated prior to clinical use. |
| doi_str_mv | 10.1016/S0090-4295(97)00541-4 |
| format | Article |
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Jet injection was evaluated in three groups of rats receiving either India ink, saline, or papaverine into the penis. The ability of the jet injection to penetrate through the tunica albuginea and deliver liquid to the corpora cavernosa smooth muscle was assessed by the degree of staining within the corpus cavernosum (ink group), histologic change (saline group), and rise in intracavernous pressure (papaverine group). Erectile capacity following cavernous nerve electric stimulation was compared before and 1 hour after injection of saline or papaverine.
Ink traversed the skin and tunica albuginea with extensive deposition noted within the cavernous spaces. Varying degrees of subcutaneous hemorrhage were seen with saline jet injection; however, the corpus cavernous smooth muscles showed no evidence of injury. Jet injection of papaverine 3250
gmg significantly increased cavernous pressure (39.4 ± 4.6 cm H
2O) compared with saline injection (2.8 ± 1.3 cm H
2O).
We conclude that acute jet injection is an effective method for intracavernous delivery of drugs. Long-term effects should be evaluated prior to clinical use.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/S0090-4295(97)00541-4</identifier><identifier>PMID: 9426740</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Carbon ; Coloring Agents - administration & dosage ; Evaluation Studies as Topic ; Genital system. Mammary gland ; Hemodynamics ; Injections - instrumentation ; Injections - methods ; Injections, Jet - instrumentation ; Injections, Jet - methods ; Male ; Medical sciences ; Needles ; Papaverine - administration & dosage ; Penis - anatomy & histology ; Penis - drug effects ; Penis - physiology ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Rats ; Rats, Sprague-Dawley ; Sodium Chloride - administration & dosage ; Vasodilator Agents - administration & dosage</subject><ispartof>Urology (Ridgewood, N.J.), 1997-12, Vol.50 (6), p.994-998</ispartof><rights>1997 Elsevier Science Inc. all rights reserved</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-5a75eafae64518a7cf8851fe38966871f2d64f4aa0f89984b758806beaf0b83a3</citedby><cites>FETCH-LOGICAL-c389t-5a75eafae64518a7cf8851fe38966871f2d64f4aa0f89984b758806beaf0b83a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0090-4295(97)00541-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2193891$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9426740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seyam, Raouf M.</creatorcontrib><creatorcontrib>Bégin, Louis R.</creatorcontrib><creatorcontrib>Tu, Le Mai</creatorcontrib><creatorcontrib>Dion, Stéphane B.</creatorcontrib><creatorcontrib>Merlin, Scott L.</creatorcontrib><creatorcontrib>Brock, Gerald B.</creatorcontrib><title>Evaluation of a no-needle penile injector: a preliminary study evaluating tissue penetration and its hemodynamic consequences in the rat</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Intracavernous needle injection is an effective delivery method for pharmacotherapy of erectile dysfunction. Needle phobia, pain, and concern about local tissue injury have stimulated the search for new, less invasive means of inducing penile erection. In this preliminary communication, we evaluate a jet injector as an alternative to needle injection for intracavernous delivery of vasoactive drugs.
Jet injection was evaluated in three groups of rats receiving either India ink, saline, or papaverine into the penis. The ability of the jet injection to penetrate through the tunica albuginea and deliver liquid to the corpora cavernosa smooth muscle was assessed by the degree of staining within the corpus cavernosum (ink group), histologic change (saline group), and rise in intracavernous pressure (papaverine group). Erectile capacity following cavernous nerve electric stimulation was compared before and 1 hour after injection of saline or papaverine.
Ink traversed the skin and tunica albuginea with extensive deposition noted within the cavernous spaces. Varying degrees of subcutaneous hemorrhage were seen with saline jet injection; however, the corpus cavernous smooth muscles showed no evidence of injury. Jet injection of papaverine 3250
gmg significantly increased cavernous pressure (39.4 ± 4.6 cm H
2O) compared with saline injection (2.8 ± 1.3 cm H
2O).
We conclude that acute jet injection is an effective method for intracavernous delivery of drugs. Long-term effects should be evaluated prior to clinical use.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon</subject><subject>Coloring Agents - administration & dosage</subject><subject>Evaluation Studies as Topic</subject><subject>Genital system. Mammary gland</subject><subject>Hemodynamics</subject><subject>Injections - instrumentation</subject><subject>Injections - methods</subject><subject>Injections, Jet - instrumentation</subject><subject>Injections, Jet - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Needles</subject><subject>Papaverine - administration & dosage</subject><subject>Penis - anatomy & histology</subject><subject>Penis - drug effects</subject><subject>Penis - physiology</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sodium Chloride - administration & dosage</subject><subject>Vasodilator Agents - administration & dosage</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0EKqHwCJW8QAgW09oT_7KpUFWgUqUugLXleK6pqxk72J5KeQMeGycZZcvKi_Od63vPQeiCkktKqLj6QYgmHes1_6jlJ0I4ox17gVaU97LTWvOXaHVCXqM3pTwRQoQQ8gydadYLycgK_b19tuNsa0gRJ48tjqmLAMMIeAsxtCfEJ3A15c9N3GYYwxSizTtc6jzsMCz2-BvXUMp8sEHNx4k2DjjUgh9hSsMu2ik47FIs8GeG6KC04bg-Am74W_TK27HAu-U9R7--3v68-d7dP3y7u_ly37m10rXjVnKw3oJgnCornVeKUw9NFEJJ6vtBMM-sJV5prdhGcqWI2DQP2ai1XZ-jD8e525zaFqWaKRQH42gjpLkYqTlZU8UayI-gy6mUDN5sc5ja5YYSs2_AHBow-3iNlubQgNn7LpYP5s0Ew8m1RN7094tui7Ojzza6UE5YT3W7hTbs-ohBC-M5QDbFhX1oQ8itDzOk8J9F_gHJTKVY</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Seyam, Raouf M.</creator><creator>Bégin, Louis R.</creator><creator>Tu, Le Mai</creator><creator>Dion, Stéphane B.</creator><creator>Merlin, Scott L.</creator><creator>Brock, Gerald B.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>Evaluation of a no-needle penile injector: a preliminary study evaluating tissue penetration and its hemodynamic consequences in the rat</title><author>Seyam, Raouf M. ; Bégin, Louis R. ; Tu, Le Mai ; Dion, Stéphane B. ; Merlin, Scott L. ; Brock, Gerald B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-5a75eafae64518a7cf8851fe38966871f2d64f4aa0f89984b758806beaf0b83a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbon</topic><topic>Coloring Agents - administration & dosage</topic><topic>Evaluation Studies as Topic</topic><topic>Genital system. Mammary gland</topic><topic>Hemodynamics</topic><topic>Injections - instrumentation</topic><topic>Injections - methods</topic><topic>Injections, Jet - instrumentation</topic><topic>Injections, Jet - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Needles</topic><topic>Papaverine - administration & dosage</topic><topic>Penis - anatomy & histology</topic><topic>Penis - drug effects</topic><topic>Penis - physiology</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sodium Chloride - administration & dosage</topic><topic>Vasodilator Agents - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seyam, Raouf M.</creatorcontrib><creatorcontrib>Bégin, Louis R.</creatorcontrib><creatorcontrib>Tu, Le Mai</creatorcontrib><creatorcontrib>Dion, Stéphane B.</creatorcontrib><creatorcontrib>Merlin, Scott L.</creatorcontrib><creatorcontrib>Brock, Gerald B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seyam, Raouf M.</au><au>Bégin, Louis R.</au><au>Tu, Le Mai</au><au>Dion, Stéphane B.</au><au>Merlin, Scott L.</au><au>Brock, Gerald B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a no-needle penile injector: a preliminary study evaluating tissue penetration and its hemodynamic consequences in the rat</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>50</volume><issue>6</issue><spage>994</spage><epage>998</epage><pages>994-998</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>Intracavernous needle injection is an effective delivery method for pharmacotherapy of erectile dysfunction. Needle phobia, pain, and concern about local tissue injury have stimulated the search for new, less invasive means of inducing penile erection. In this preliminary communication, we evaluate a jet injector as an alternative to needle injection for intracavernous delivery of vasoactive drugs.
Jet injection was evaluated in three groups of rats receiving either India ink, saline, or papaverine into the penis. The ability of the jet injection to penetrate through the tunica albuginea and deliver liquid to the corpora cavernosa smooth muscle was assessed by the degree of staining within the corpus cavernosum (ink group), histologic change (saline group), and rise in intracavernous pressure (papaverine group). Erectile capacity following cavernous nerve electric stimulation was compared before and 1 hour after injection of saline or papaverine.
Ink traversed the skin and tunica albuginea with extensive deposition noted within the cavernous spaces. Varying degrees of subcutaneous hemorrhage were seen with saline jet injection; however, the corpus cavernous smooth muscles showed no evidence of injury. Jet injection of papaverine 3250
gmg significantly increased cavernous pressure (39.4 ± 4.6 cm H
2O) compared with saline injection (2.8 ± 1.3 cm H
2O).
We conclude that acute jet injection is an effective method for intracavernous delivery of drugs. Long-term effects should be evaluated prior to clinical use.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9426740</pmid><doi>10.1016/S0090-4295(97)00541-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Urology (Ridgewood, N.J.), 1997-12, Vol.50 (6), p.994-998 |
| issn | 0090-4295 1527-9995 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Carbon Coloring Agents - administration & dosage Evaluation Studies as Topic Genital system. Mammary gland Hemodynamics Injections - instrumentation Injections - methods Injections, Jet - instrumentation Injections, Jet - methods Male Medical sciences Needles Papaverine - administration & dosage Penis - anatomy & histology Penis - drug effects Penis - physiology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Sprague-Dawley Sodium Chloride - administration & dosage Vasodilator Agents - administration & dosage |
| title | Evaluation of a no-needle penile injector: a preliminary study evaluating tissue penetration and its hemodynamic consequences in the rat |
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