[8] Calcium ion transport in mitochondria
This chapter discusses the calcium ion transport in mitochondria. Mitochondria are organelles capable of accumulating and releasing calcium ion (Ca2+) in the cell. Calcium channels and pumps in the plasma membrane determine the overall cellular Ca2+ content. Mammalian mitochondria accumulate Ca2+ ma...
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| Veröffentlicht in: | Methods in Enzymology 1989, Vol.174, p.68-85 |
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| container_title | Methods in Enzymology |
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| creator | Saris, Nils-Erik Leo Allshire, Ashley |
| description | This chapter discusses the calcium ion transport in mitochondria. Mitochondria are organelles capable of accumulating and releasing calcium ion (Ca2+) in the cell. Calcium channels and pumps in the plasma membrane determine the overall cellular Ca2+ content. Mammalian mitochondria accumulate Ca2+ mainly by an electrogenic mechanism that drives Ca2+ into the matrix at the expense of the membrane potential generated by the respiration or hydrolysis of Adenosine triphosphate (ATP) while efflux of Ca2+ occurs mainly by other electroneutral mechanisms. Under physiological conditions, the distribution of Ca2+ between cytosol and mitochondria is, thus, influenced by the kinetic properties of the influx and efflux mechanisms. Increase in permeability is correlated with the transition of an increasing proportion of the mitochondrial population from an aggregated to an orthodox configuration. |
| doi_str_mv | 10.1016/0076-6879(89)74011-8 |
| format | Article |
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Mitochondria are organelles capable of accumulating and releasing calcium ion (Ca2+) in the cell. Calcium channels and pumps in the plasma membrane determine the overall cellular Ca2+ content. Mammalian mitochondria accumulate Ca2+ mainly by an electrogenic mechanism that drives Ca2+ into the matrix at the expense of the membrane potential generated by the respiration or hydrolysis of Adenosine triphosphate (ATP) while efflux of Ca2+ occurs mainly by other electroneutral mechanisms. Under physiological conditions, the distribution of Ca2+ between cytosol and mitochondria is, thus, influenced by the kinetic properties of the influx and efflux mechanisms. Increase in permeability is correlated with the transition of an increasing proportion of the mitochondrial population from an aggregated to an orthodox configuration.</description><identifier>ISSN: 0076-6879</identifier><identifier>ISBN: 0121820750</identifier><identifier>ISBN: 9780121820756</identifier><identifier>EISSN: 1557-7988</identifier><identifier>DOI: 10.1016/0076-6879(89)74011-8</identifier><identifier>PMID: 2633033</identifier><identifier>CODEN: MENZAU</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Science & Technology</publisher><subject>Animals ; Biological and medical sciences ; Biological Transport, Active ; Calcium - metabolism ; Calcium Channels ; Calcium-Binding Proteins - metabolism ; Calibration ; Cell physiology ; Electrodes ; Fundamental and applied biological sciences. 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Mitochondria are organelles capable of accumulating and releasing calcium ion (Ca2+) in the cell. Calcium channels and pumps in the plasma membrane determine the overall cellular Ca2+ content. Mammalian mitochondria accumulate Ca2+ mainly by an electrogenic mechanism that drives Ca2+ into the matrix at the expense of the membrane potential generated by the respiration or hydrolysis of Adenosine triphosphate (ATP) while efflux of Ca2+ occurs mainly by other electroneutral mechanisms. Under physiological conditions, the distribution of Ca2+ between cytosol and mitochondria is, thus, influenced by the kinetic properties of the influx and efflux mechanisms. Increase in permeability is correlated with the transition of an increasing proportion of the mitochondrial population from an aggregated to an orthodox configuration.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Transport, Active</subject><subject>Calcium - metabolism</subject><subject>Calcium Channels</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>Calibration</subject><subject>Cell physiology</subject><subject>Electrodes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Intracellular Membranes - metabolism</subject><subject>Membrane and intracellular transports</subject><subject>Methods</subject><subject>Mitochondria, Liver - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Rats</subject><subject>Sodium - metabolism</subject><subject>Strontium - metabolism</subject><issn>0076-6879</issn><issn>1557-7988</issn><isbn>0121820750</isbn><isbn>9780121820756</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtLAzEUhYMPaq39BwqzUexiNDeZvDaCFF9QcKMrkZDJJBiZR01mBP-9U1u8m7s4HwfOOQidAr4CDPwaY8FzLoW6lGohCgyQyz00BcZELpSU--gYAwFJsGD4AE3_-SM0T-kTj8eEIKyYoAnhlGJKp2jxJt-zpaltGJosdG3WR9OmdRf7LLRZE_rOfnRtFYM5QYfe1MnNd3-GXu_vXpaP-er54Wl5u8otLUifKwAQpeGyBEaxIdiC5KK0AnuwBljBKltSZTzjElPvPThmjXPUC1KCl3SGLra-69h9DS71ugnJuro2reuGpIVimFDKR_BsBw5l4yq9jqEx8Ufvso36-U43yZraj8FsSP8YKMoKLmHkbracG1N9Bxd1ssG11lUhOtvrqgsasN5soDed6k2nWir9t4GW9Be9P3NF</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Saris, Nils-Erik Leo</creator><creator>Allshire, Ashley</creator><general>Elsevier Science & Technology</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>[8] Calcium ion transport in mitochondria</title><author>Saris, Nils-Erik Leo ; Allshire, Ashley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-91117ba68b1530a20c1867bc70f1ca1545dcb39af56803fff1e5caee3f72b1f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Transport, Active</topic><topic>Calcium - metabolism</topic><topic>Calcium Channels</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>Calibration</topic><topic>Cell physiology</topic><topic>Electrodes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Intracellular Membranes - metabolism</topic><topic>Membrane and intracellular transports</topic><topic>Methods</topic><topic>Mitochondria, Liver - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Rats</topic><topic>Sodium - metabolism</topic><topic>Strontium - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saris, Nils-Erik Leo</creatorcontrib><creatorcontrib>Allshire, Ashley</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Methods in Enzymology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saris, Nils-Erik Leo</au><au>Allshire, Ashley</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>[8] Calcium ion transport in mitochondria</atitle><jtitle>Methods in Enzymology</jtitle><addtitle>Methods Enzymol</addtitle><date>1989</date><risdate>1989</risdate><volume>174</volume><spage>68</spage><epage>85</epage><pages>68-85</pages><issn>0076-6879</issn><eissn>1557-7988</eissn><isbn>0121820750</isbn><isbn>9780121820756</isbn><coden>MENZAU</coden><abstract>This chapter discusses the calcium ion transport in mitochondria. Mitochondria are organelles capable of accumulating and releasing calcium ion (Ca2+) in the cell. Calcium channels and pumps in the plasma membrane determine the overall cellular Ca2+ content. Mammalian mitochondria accumulate Ca2+ mainly by an electrogenic mechanism that drives Ca2+ into the matrix at the expense of the membrane potential generated by the respiration or hydrolysis of Adenosine triphosphate (ATP) while efflux of Ca2+ occurs mainly by other electroneutral mechanisms. Under physiological conditions, the distribution of Ca2+ between cytosol and mitochondria is, thus, influenced by the kinetic properties of the influx and efflux mechanisms. 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| ispartof | Methods in Enzymology, 1989, Vol.174, p.68-85 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ScienceDirect eBooks |
| subjects | Animals Biological and medical sciences Biological Transport, Active Calcium - metabolism Calcium Channels Calcium-Binding Proteins - metabolism Calibration Cell physiology Electrodes Fundamental and applied biological sciences. Psychology Intracellular Membranes - metabolism Membrane and intracellular transports Methods Mitochondria, Liver - metabolism Molecular and cellular biology Rats Sodium - metabolism Strontium - metabolism |
| title | [8] Calcium ion transport in mitochondria |
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