The 9- O-acetylated disialosyl carbohydrate sequence of CDw60 is a marker on activated human B lymphocytes
Gangliosides with a terminal 9- O-acetylated disialosyl group (CDw60 structures) show a restricted surface expression on human leukocytes. Hithereto, they have only been detected on subpopulations of human T lymphocytes. Using the defined CDw60 antibody UM4D4 and two new antibodies with preferential...
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| Veröffentlicht in: | Immunology letters 1997-12, Vol.59 (3), p.151-157 |
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| container_end_page | 157 |
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| container_issue | 3 |
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| container_title | Immunology letters |
| container_volume | 59 |
| creator | Vater, Margit Kniep, Bernhard Groß, Hans-Jürgen Claus, Christine Dippold, Wolfgang Schwartz-Albiez, Reinhard |
| description | Gangliosides with a terminal 9-
O-acetylated disialosyl group (CDw60 structures) show a restricted surface expression on human leukocytes. Hithereto, they have only been detected on subpopulations of human T lymphocytes. Using the defined CDw60 antibody UM4D4 and two new antibodies with preferential CDw60 activities, F6 and Z17, we demonstrate for the first time that CDw60 is an activation marker on human B lymphocytes. In vitro phorbol ester-stimulated human peripheral blood B lymphocytes as well as in vivo activated tonsillar B lymphocytes became CDw60 positive. CDw60 expression of these cells exceeds that of resting and activated T-lymphocytes. |
| doi_str_mv | 10.1016/S0165-2478(97)00116-8 |
| format | Article |
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O-acetylated disialosyl group (CDw60 structures) show a restricted surface expression on human leukocytes. Hithereto, they have only been detected on subpopulations of human T lymphocytes. Using the defined CDw60 antibody UM4D4 and two new antibodies with preferential CDw60 activities, F6 and Z17, we demonstrate for the first time that CDw60 is an activation marker on human B lymphocytes. In vitro phorbol ester-stimulated human peripheral blood B lymphocytes as well as in vivo activated tonsillar B lymphocytes became CDw60 positive. CDw60 expression of these cells exceeds that of resting and activated T-lymphocytes.</description><subject>9- O-acetylation</subject><subject>Acetylation</subject><subject>Adult</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - chemistry</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, Differentiation, T-Lymphocyte - biosynthesis</subject><subject>Antigens, Differentiation, T-Lymphocyte - chemistry</subject><subject>Antigens, Differentiation, T-Lymphocyte - immunology</subject><subject>B lymphocyte activation</subject><subject>B-Lymphocytes - immunology</subject><subject>Biomarkers</subject><subject>Carbohydrate Sequence</subject><subject>CDw60</subject><subject>Glycosphingolipids</subject><subject>Humans</subject><subject>Lymphocyte Activation - immunology</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - immunology</subject><subject>Structure-Activity Relationship</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElv2zAQhYkiReKk_QkBeArSg1IuopZTkbpZCgTwoe6ZGFFDmK5kuqTkQv--9AJfc5k5vDfzZj5Cbjl74IwXX3-lojKRl9V9XX5hjPMiqz6QGa_KOmMqFxdkdrZckesY18mkZC4vyWWd85oJMSPr5QppndFFBgaHqYMBW9q66KDzceqogdD41dSGJNCIf0fcGKTe0vmPfwWjLlKgPYQ_GKjfUDCD2x1WrMYeNvQ77aZ-u_JmGjB-Ih8tdBE_n_oN-f38tJy_Zm-Ll5_zx7fMyIINWSOlyKEVwEG0YAUUDMA2edOUrFGMWVZZW9VMcpSFkgpRWSg5YgOSc6jkDbk77t0Gn-6Ng-5dNNh1sEE_Rl3WiiVIIhnV0WiCjzGg1dvg0jOT5kzvGesDY70HqOtSHxjrfcDtKWBsemzPUyeoSf921DF9uXMYdDRuz611Ac2gW-_eSfgPzc-MHQ</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Vater, Margit</creator><creator>Kniep, Bernhard</creator><creator>Groß, Hans-Jürgen</creator><creator>Claus, Christine</creator><creator>Dippold, Wolfgang</creator><creator>Schwartz-Albiez, Reinhard</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>The 9- O-acetylated disialosyl carbohydrate sequence of CDw60 is a marker on activated human B lymphocytes</title><author>Vater, Margit ; 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| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 1997-12, Vol.59 (3), p.151-157 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 9- O-acetylation Acetylation Adult Antibodies, Monoclonal - immunology Antigens, CD - biosynthesis Antigens, CD - chemistry Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Differentiation, T-Lymphocyte - chemistry Antigens, Differentiation, T-Lymphocyte - immunology B lymphocyte activation B-Lymphocytes - immunology Biomarkers Carbohydrate Sequence CDw60 Glycosphingolipids Humans Lymphocyte Activation - immunology Middle Aged Molecular Sequence Data Polysaccharides - chemistry Polysaccharides - immunology Structure-Activity Relationship |
| title | The 9- O-acetylated disialosyl carbohydrate sequence of CDw60 is a marker on activated human B lymphocytes |
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