Sublingual Absorption of Salbutamol in the Guinea-pig

Clinical observations both claim and refute sublingual absorption of salbutamol. To resolve this issue, the capacity of salbutamol to inhibit substantial bronchoconstrictor responses to histamine has been defined for both intravenous injection of saline in the anaesthetized ventilated guinea-pig. Su...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pulmonary pharmacology & therapeutics 1997-04, Vol.10 (2), p.67-69
Hauptverfasser:	Spina, D., Page, C.P., Morley, J., Mazzoni, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Sublingual Albuterol - administration & dosage Animals Bronchoconstriction Bronchoconstriction - drug effects Bronchodilator Agents - administration & dosage Guinea Pigs Guinea-pig Histamine Injections, Intravenous Intravenous Male Salbutamol Sublingual
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Clinical observations both claim and refute sublingual absorption of salbutamol. To resolve this issue, the capacity of salbutamol to inhibit substantial bronchoconstrictor responses to histamine has been defined for both intravenous injection of saline in the anaesthetized ventilated guinea-pig. Substantial sublingual absorption was observed. It is suggested that low dose sublingual formulations might have advantage over inhalation forms of sympathomimetics.
ISSN:	1094-5539 1522-9629
DOI:	10.1006/pupt.1997.0080