Up-regulation of dopamine D1-receptors in the brain of 28-day-old rats exposed to the delta (delta) opioid agonist SNC80 during the preweaning period
Twenty-eight-day-old rats exposed to the delta (delta) opioid receptor agonist SNC80 during the preweaning period exhibited a significant increase in the density and apparent dissociation constant of striatal dopamine D1-receptors. There were no significant effects on the binding characteristics of...
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| Veröffentlicht in: | Brain research. Developmental brain research 1997-11, Vol.103 (2), p.209-211 |
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| container_title | Brain research. Developmental brain research |
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| creator | Shieh, G J Ravis, W R Walters, D E |
| description | Twenty-eight-day-old rats exposed to the delta (delta) opioid receptor agonist SNC80 during the preweaning period exhibited a significant increase in the density and apparent dissociation constant of striatal dopamine D1-receptors. There were no significant effects on the binding characteristics of striatal D2-receptors or on D1- or D2-receptors in the nucleus accumbens. The results suggest that delta-opioid receptor mechanisms might be involved in certain neurological changes observed in offspring of mother addicted to opioids during nursing. |
| doi_str_mv | 10.1016/S0165-3806(97)81798-1 |
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There were no significant effects on the binding characteristics of striatal D2-receptors or on D1- or D2-receptors in the nucleus accumbens. The results suggest that delta-opioid receptor mechanisms might be involved in certain neurological changes observed in offspring of mother addicted to opioids during nursing.</description><identifier>ISSN: 0165-3806</identifier><identifier>DOI: 10.1016/S0165-3806(97)81798-1</identifier><identifier>PMID: 9427486</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Animals ; Animals, Suckling ; Benzamides - pharmacology ; Brain - drug effects ; Brain - metabolism ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Female ; Male ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Piperazines - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D2 - biosynthesis ; Receptors, Dopamine D2 - metabolism ; Receptors, Opioid, delta - agonists ; Up-Regulation</subject><ispartof>Brain research. 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The results suggest that delta-opioid receptor mechanisms might be involved in certain neurological changes observed in offspring of mother addicted to opioids during nursing.</description><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Benzamides - pharmacology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Female</subject><subject>Male</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Piperazines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Dopamine D2 - biosynthesis</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Receptors, Opioid, delta - agonists</subject><subject>Up-Regulation</subject><issn>0165-3806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc9OwzAMxnMAjTF4hEk5oe1QSNYlTY9o_JUmOIydo7RxRlDXhKQV7EF4X7pu2sWW7Z9t6fsQGlNySwnld6susCQVhE_ybCpolouEnqHhqX2BLmP8IoTQVNABGuTzWTYXfIj-1j4JsGkr1VhXY2ewdl5tbQ34gXaTEnzjQsS2xs0n4CIo21MzkWi1S1ylcVBNxPDrXQSNG9dzGqpG4Umfpth566zGauNqGxu8elsIgnUbbL3paR_gB1S9Lz0E6_QVOjeqinB9zCO0fnr8WLwky_fn18X9MikpozxJZ4brVOcpUwUVhlGSc05KaoTgOjPMZApSUrA5F2ZOWJGxkoECpbXQOackHaGbw10f3HcLsZFbG0uoKlWDa6PMctZJNuMdyA5gGVyMAYz0wW5V2ElK5N4C2Vsg91rLPJO9BZJ2e-Pjg7bYgj5tHfVP_wEFoYR0</recordid><startdate>19971112</startdate><enddate>19971112</enddate><creator>Shieh, G J</creator><creator>Ravis, W R</creator><creator>Walters, D E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971112</creationdate><title>Up-regulation of dopamine D1-receptors in the brain of 28-day-old rats exposed to the delta (delta) opioid agonist SNC80 during the preweaning period</title><author>Shieh, G J ; Ravis, W R ; Walters, D E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1516-32f6d3d935ab18f5109660c1f886d7f5f7ae30b5468f405b75c5eaeadd8d96103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Animals, Suckling</topic><topic>Benzamides - pharmacology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Female</topic><topic>Male</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Piperazines - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Dopamine D2 - biosynthesis</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Receptors, Opioid, delta - agonists</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shieh, G J</creatorcontrib><creatorcontrib>Ravis, W R</creatorcontrib><creatorcontrib>Walters, D E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. Developmental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shieh, G J</au><au>Ravis, W R</au><au>Walters, D E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Up-regulation of dopamine D1-receptors in the brain of 28-day-old rats exposed to the delta (delta) opioid agonist SNC80 during the preweaning period</atitle><jtitle>Brain research. Developmental brain research</jtitle><addtitle>Brain Res Dev Brain Res</addtitle><date>1997-11-12</date><risdate>1997</risdate><volume>103</volume><issue>2</issue><spage>209</spage><epage>211</epage><pages>209-211</pages><issn>0165-3806</issn><abstract>Twenty-eight-day-old rats exposed to the delta (delta) opioid receptor agonist SNC80 during the preweaning period exhibited a significant increase in the density and apparent dissociation constant of striatal dopamine D1-receptors. 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| identifier | ISSN: 0165-3806 |
| ispartof | Brain research. Developmental brain research, 1997-11, Vol.103 (2), p.209-211 |
| issn | 0165-3806 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Animals, Suckling Benzamides - pharmacology Brain - drug effects Brain - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism Female Male Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Piperazines - pharmacology Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - biosynthesis Receptors, Dopamine D2 - metabolism Receptors, Opioid, delta - agonists Up-Regulation |
| title | Up-regulation of dopamine D1-receptors in the brain of 28-day-old rats exposed to the delta (delta) opioid agonist SNC80 during the preweaning period |
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