Regulation of m2 Muscarinic Receptor Gene Expression by Platelet-Derived Growth Factor: Involvement of Extracellular Signal-Regulated Protein Kinases in the Down-Regulation Process

To study the role of mitogen-activated protein kinase in the regulation of M2 receptors, we studied the effect of platelet-derived growth factor (PDGF) on M2 receptor gene expression. PDGF (4 ng/ml) caused a time-dependent decrease in M2 receptor number and in m2 receptor mRNA levels in HEL 299 cell...

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Veröffentlicht in:	Molecular pharmacology 1997-12, Vol.52 (6), p.966-973
Hauptverfasser:	Rousell, Jonathan, Haddad, El-Bdaoui, Lindsay, Mark A., Barnes, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Northern Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calcium-Calmodulin-Dependent Protein Kinases - physiology Cyclic AMP - metabolism Down-Regulation - physiology Enzyme Activation - drug effects Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Humans Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases Platelet-Derived Growth Factor - pharmacology Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Receptor, Muscarinic M2 Receptors, Muscarinic - biosynthesis Receptors, Muscarinic - genetics Receptors, Muscarinic - metabolism RNA, Messenger - metabolism Signal Transduction - physiology
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