Role of endothelin, nitric oxide and L-arginine release in ischaemia/reperfusion injury of rat heart

We tested the hypothesis that endothelin-1 (ET-1) aggravates ischaemia/reperfusion injury by stimulating cellular L-arginine depletion, which would result in reduced synthesis of nitric oxide (NO) and withdrawal of cardioprotection. Five groups of rat hearts (n = 5 each) were perfused at 9 ml/min pe...

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Veröffentlicht in:	Cardiovascular research 1997-10, Vol.36 (1), p.60-66
Hauptverfasser:	BRUNNER, F, LEONHARD, B, KUKOVETZ, W. R, MAYER, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Arginine - analysis Arginine - metabolism Arginine - pharmacology Biological and medical sciences Cardiology. Vascular system Chromatography, High Pressure Liquid Coronary heart disease Cyclic GMP - analysis Cyclic GMP - metabolism Endothelin Receptor Antagonists Endothelin-1 - analysis Endothelin-1 - metabolism Heart L-Lactate Dehydrogenase - analysis L-Lactate Dehydrogenase - metabolism Medical sciences Myocardial Reperfusion Injury - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Oligopeptides - pharmacology Penicillamine - analogs & derivatives Penicillamine - pharmacology Perfusion Rats Rats, Sprague-Dawley S-Nitroso-N-Acetylpenicillamine Vasodilator Agents - pharmacology
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