Expression of neural BC200 RNA in human tumours
BC200 RNA is a 200‐nucleotide‐long non‐messenger RNA that is selectively expressed in the primate nervous system, where it has been identified in somatodendritic domains of a subset of neurons. BC200 RNA is not normally expressed in non‐neuronal somatic cells; it has been shown, however, to be expre...
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| Veröffentlicht in: | The Journal of pathology 1997-11, Vol.183 (3), p.345-351 |
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| creator | Chen, Wei Böcker, Werner Brosius, Jürgen Tiedge, Henri |
| description | BC200 RNA is a 200‐nucleotide‐long non‐messenger RNA that is selectively expressed in the primate nervous system, where it has been identified in somatodendritic domains of a subset of neurons. BC200 RNA is not normally expressed in non‐neuronal somatic cells; it has been shown, however, to be expressed in germ cells and in cultured immortal cell lines of various non‐neural origins. In order to investigate whether the neuron‐specific expression of BC200 RNA is also deregulated during tumourigenesis in non‐neural human tissues, 80 different tumour specimens, representing 19 different tumour types, were screened for the presence of the RNA. BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. BC200 RNA was not detectable in bladder, colon, kidney, or liver carcinoma tissues examined in this study. These results demonstrate that BC200 expression is deregulated under certain neoplastic conditions. The expression of BC200 RNA in non‐neural tumours may indicate a functional interrelationship with induction and/or progression of such tumours. © 1997 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1096-9896(199711)183:3<345::AID-PATH930>3.0.CO;2-8 |
| format | Article |
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BC200 RNA is not normally expressed in non‐neuronal somatic cells; it has been shown, however, to be expressed in germ cells and in cultured immortal cell lines of various non‐neural origins. In order to investigate whether the neuron‐specific expression of BC200 RNA is also deregulated during tumourigenesis in non‐neural human tissues, 80 different tumour specimens, representing 19 different tumour types, were screened for the presence of the RNA. BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. BC200 RNA was not detectable in bladder, colon, kidney, or liver carcinoma tissues examined in this study. These results demonstrate that BC200 expression is deregulated under certain neoplastic conditions. The expression of BC200 RNA in non‐neural tumours may indicate a functional interrelationship with induction and/or progression of such tumours. © 1997 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/(SICI)1096-9896(199711)183:3<345::AID-PATH930>3.0.CO;2-8</identifier><identifier>PMID: 9422992</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>BC200 RNA ; Biological and medical sciences ; Blotting, Northern ; carcinogenesis ; Carcinogenesis, carcinogens and anticarcinogens ; carcinoma ; Electrophoresis, Agar Gel ; Female ; Foods and miscellaneous ; Gene Expression ; Humans ; In Situ Hybridization ; in situhybridization ; Medical sciences ; Neoplasms - genetics ; Neoplasms - metabolism ; Oligonucleotide Probes - chemistry ; RNA - isolation & purification ; RNA, Neoplasm - metabolism ; RNA, Small Nuclear - metabolism ; Tissue Distribution ; Tumors</subject><ispartof>The Journal of pathology, 1997-11, Vol.183 (3), p.345-351</ispartof><rights>Copyright © 1997 John Wiley & Sons, Ltd.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4380-b14659e93ad9570d2ada232efd4ec8dcf5622cb784b5f05ff3ab2322aef30cc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-9896%28199711%29183%3A3%3C345%3A%3AAID-PATH930%3E3.0.CO%3B2-8$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-9896%28199711%29183%3A3%3C345%3A%3AAID-PATH930%3E3.0.CO%3B2-8$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2055980$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9422992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Böcker, Werner</creatorcontrib><creatorcontrib>Brosius, Jürgen</creatorcontrib><creatorcontrib>Tiedge, Henri</creatorcontrib><title>Expression of neural BC200 RNA in human tumours</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>BC200 RNA is a 200‐nucleotide‐long non‐messenger RNA that is selectively expressed in the primate nervous system, where it has been identified in somatodendritic domains of a subset of neurons. BC200 RNA is not normally expressed in non‐neuronal somatic cells; it has been shown, however, to be expressed in germ cells and in cultured immortal cell lines of various non‐neural origins. In order to investigate whether the neuron‐specific expression of BC200 RNA is also deregulated during tumourigenesis in non‐neural human tissues, 80 different tumour specimens, representing 19 different tumour types, were screened for the presence of the RNA. BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. BC200 RNA was not detectable in bladder, colon, kidney, or liver carcinoma tissues examined in this study. These results demonstrate that BC200 expression is deregulated under certain neoplastic conditions. The expression of BC200 RNA in non‐neural tumours may indicate a functional interrelationship with induction and/or progression of such tumours. © 1997 John Wiley & Sons, Ltd.</description><subject>BC200 RNA</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>carcinogenesis</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>carcinoma</subject><subject>Electrophoresis, Agar Gel</subject><subject>Female</subject><subject>Foods and miscellaneous</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>in situhybridization</subject><subject>Medical sciences</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Oligonucleotide Probes - chemistry</subject><subject>RNA - isolation & purification</subject><subject>RNA, Neoplasm - metabolism</subject><subject>RNA, Small Nuclear - metabolism</subject><subject>Tissue Distribution</subject><subject>Tumors</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1r1EAUhgdR6tr6E4RciLQX2c5nklmldE2_FsuuaKWCF4fJZIZG87HObLD9986SdG8syFwcOOedh5cHoVOCpwRjenz4dZEvjgiWSSwzmRwSKVNCjkjGZuwD42I2my_O4s_zmyvJ8Amb4mm-ek_j7Bma7D49R5OAojHjJH2JXnn_E2MspRB7aE9ySqWkE3R8fr92xvuqa6PORq3pnaqjjznFOPqynEdVG931jWqjTd90vfMH6IVVtTevx7mPvl2c3-RX8fXqcpHPr2PNWYbjgvBESCOZKqVIcUlVqSijxpbc6KzUViSU6iLNeCEsFtYyVYQ7VcYyrDVl--jdwF277ndv_AaaymtT16o1Xe8hlVzyJElC8PsQ1K7z3hkLa1c1yj0AwbB1CbB1CVstsNUCg0sILiE8LgCCSxhdhhWGfAUUsoB-M3boi8aUO_AoL9zfjnfltaqtU62u_C5GsRAywyH2Y4j9qWrz8E-9_7V7utzjKtDjgV75jbnf0ZX7BUnKUgG3y0v4JG_l8owkwNhfVuiqOA</recordid><startdate>199711</startdate><enddate>199711</enddate><creator>Chen, Wei</creator><creator>Böcker, Werner</creator><creator>Brosius, Jürgen</creator><creator>Tiedge, Henri</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199711</creationdate><title>Expression of neural BC200 RNA in human tumours</title><author>Chen, Wei ; Böcker, Werner ; Brosius, Jürgen ; Tiedge, Henri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4380-b14659e93ad9570d2ada232efd4ec8dcf5622cb784b5f05ff3ab2322aef30cc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>BC200 RNA</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>carcinogenesis</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>carcinoma</topic><topic>Electrophoresis, Agar Gel</topic><topic>Female</topic><topic>Foods and miscellaneous</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>in situhybridization</topic><topic>Medical sciences</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Oligonucleotide Probes - chemistry</topic><topic>RNA - isolation & purification</topic><topic>RNA, Neoplasm - metabolism</topic><topic>RNA, Small Nuclear - metabolism</topic><topic>Tissue Distribution</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Böcker, Werner</creatorcontrib><creatorcontrib>Brosius, Jürgen</creatorcontrib><creatorcontrib>Tiedge, Henri</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Wei</au><au>Böcker, Werner</au><au>Brosius, Jürgen</au><au>Tiedge, Henri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of neural BC200 RNA in human tumours</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>1997-11</date><risdate>1997</risdate><volume>183</volume><issue>3</issue><spage>345</spage><epage>351</epage><pages>345-351</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>BC200 RNA is a 200‐nucleotide‐long non‐messenger RNA that is selectively expressed in the primate nervous system, where it has been identified in somatodendritic domains of a subset of neurons. BC200 RNA is not normally expressed in non‐neuronal somatic cells; it has been shown, however, to be expressed in germ cells and in cultured immortal cell lines of various non‐neural origins. In order to investigate whether the neuron‐specific expression of BC200 RNA is also deregulated during tumourigenesis in non‐neural human tissues, 80 different tumour specimens, representing 19 different tumour types, were screened for the presence of the RNA. BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. BC200 RNA was not detectable in bladder, colon, kidney, or liver carcinoma tissues examined in this study. These results demonstrate that BC200 expression is deregulated under certain neoplastic conditions. The expression of BC200 RNA in non‐neural tumours may indicate a functional interrelationship with induction and/or progression of such tumours. © 1997 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>9422992</pmid><doi>10.1002/(SICI)1096-9896(199711)183:3<345::AID-PATH930>3.0.CO;2-8</doi><tpages>7</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | BC200 RNA Biological and medical sciences Blotting, Northern carcinogenesis Carcinogenesis, carcinogens and anticarcinogens carcinoma Electrophoresis, Agar Gel Female Foods and miscellaneous Gene Expression Humans In Situ Hybridization in situhybridization Medical sciences Neoplasms - genetics Neoplasms - metabolism Oligonucleotide Probes - chemistry RNA - isolation & purification RNA, Neoplasm - metabolism RNA, Small Nuclear - metabolism Tissue Distribution Tumors |
| title | Expression of neural BC200 RNA in human tumours |
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