Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats
In young adult rats transection of the fimbria results in loss of cholinergic cell bodies in the septum and this lesion-induced loss is prevented by intraventricular administration of NGF. The present study examined whether NGF administration is equally effective in aging animals. Eighteen-month-old...
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| Veröffentlicht in: | Neurobiology of aging 1989, Vol.10 (6), p.739-743 |
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| container_title | Neurobiology of aging |
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| creator | Montero, Claudia N. Hefti, Franz |
| description | In young adult rats transection of the fimbria results in loss of cholinergic cell bodies in the septum and this lesion-induced loss is prevented by intraventricular administration of NGF. The present study examined whether NGF administration is equally effective in aging animals. Eighteen-month-old rats received fimbrial transections and were given intraventricular injections of NGF during four weeks. Septal cholinergic neurons were then visualized using NGF receptor immunohistochemistry, which represents a reliable marker for cholinergic neurons in the septal area. The fimbrial transections reduced the number of septal NGF receptor-positive cells to a similar extent as in young animals. NGF treatment of aging rats protected these cells as effectively as in young adult rats. |
| doi_str_mv | 10.1016/0197-4580(89)90011-0 |
| format | Article |
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The present study examined whether NGF administration is equally effective in aging animals. Eighteen-month-old rats received fimbrial transections and were given intraventricular injections of NGF during four weeks. Septal cholinergic neurons were then visualized using NGF receptor immunohistochemistry, which represents a reliable marker for cholinergic neurons in the septal area. The fimbrial transections reduced the number of septal NGF receptor-positive cells to a similar extent as in young animals. NGF treatment of aging rats protected these cells as effectively as in young adult rats.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(89)90011-0</identifier><identifier>PMID: 2628784</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aging ; Aging - drug effects ; Aging - pathology ; Alzheimer's disease ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Cell Survival - drug effects ; Central nervous system ; Cholinergic neuron ; Female ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Injections, Intraventricular ; Nerve growth factor ; Nerve Growth Factors - administration & dosage ; Nerve Growth Factors - pharmacology ; Neuronal survival ; Neurons - cytology ; Neurons - drug effects ; NGF ; Rats ; Rats, Inbred Strains ; Septum ; Septum Pellucidum - cytology ; Septum Pellucidum - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurobiology of aging, 1989, Vol.10 (6), p.739-743</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-96807d411397d17c6ecea5b90529e32dd818cea4c4c240fdde50b762cb9a1c6b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0197-4580(89)90011-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6949258$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2628784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montero, Claudia N.</creatorcontrib><creatorcontrib>Hefti, Franz</creatorcontrib><title>Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>In young adult rats transection of the fimbria results in loss of cholinergic cell bodies in the septum and this lesion-induced loss is prevented by intraventricular administration of NGF. The present study examined whether NGF administration is equally effective in aging animals. Eighteen-month-old rats received fimbrial transections and were given intraventricular injections of NGF during four weeks. Septal cholinergic neurons were then visualized using NGF receptor immunohistochemistry, which represents a reliable marker for cholinergic neurons in the septal area. The fimbrial transections reduced the number of septal NGF receptor-positive cells to a similar extent as in young animals. NGF treatment of aging rats protected these cells as effectively as in young adult rats.</description><subject>Aging</subject><subject>Aging - drug effects</subject><subject>Aging - pathology</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Central nervous system</subject><subject>Cholinergic neuron</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Injections, Intraventricular</subject><subject>Nerve growth factor</subject><subject>Nerve Growth Factors - administration & dosage</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Neuronal survival</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>NGF</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Septum</subject><subject>Septum Pellucidum - cytology</subject><subject>Septum Pellucidum - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rVDEYhYModVr9BwpZiNTFrcm9-dwUpPhRKHSj65CbvHcaySRjcu-I0B9vxhlmaTcJyfucQ3IOQm8ouaKEio-Eatkxrsil0h80IZR25BlaUc5VR5mWz9HqhLxE57X-JIRIJsUZOutFr6RiK_R4m-Zid9DW4JZoC05QdoDXJf-eH_Bk3ZwLtn4TUqiNnENOeFtgr6g4Qm3nLiS_OPA45lpxnnCF7Wwjdg85hma3Dq65LiWnikPCdh3SGjer-gq9mGys8Pq4X6AfXz5_v_nW3d1_vb35dNc5Tvu500IR6Rmlg5aeSifAgeWjJrzXMPTeK6raDXPM9YxM3gMnoxS9G7WlTozDBXp_8N2W_GuBOptNqA5itAnyUo3UTCkxDE-CLVvN2MAbyA6gK-3PBSazLWFjyx9Didm3Y_bRm330Rmnzrx1Dmuzt0X8ZN-BPomMdbf7uOLfV2TgVm1yoJ0xopnuuGnZ9wKCFtgtQTHUBUqsgFHCz8Tn8_x1_AXFKrn8</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Montero, Claudia N.</creator><creator>Hefti, Franz</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats</title><author>Montero, Claudia N. ; Hefti, Franz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-96807d411397d17c6ecea5b90529e32dd818cea4c4c240fdde50b762cb9a1c6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aging</topic><topic>Aging - drug effects</topic><topic>Aging - pathology</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Survival - drug effects</topic><topic>Central nervous system</topic><topic>Cholinergic neuron</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Injections, Intraventricular</topic><topic>Nerve growth factor</topic><topic>Nerve Growth Factors - administration & dosage</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>Neuronal survival</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>NGF</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Septum</topic><topic>Septum Pellucidum - cytology</topic><topic>Septum Pellucidum - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montero, Claudia N.</creatorcontrib><creatorcontrib>Hefti, Franz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montero, Claudia N.</au><au>Hefti, Franz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1989</date><risdate>1989</risdate><volume>10</volume><issue>6</issue><spage>739</spage><epage>743</epage><pages>739-743</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>In young adult rats transection of the fimbria results in loss of cholinergic cell bodies in the septum and this lesion-induced loss is prevented by intraventricular administration of NGF. The present study examined whether NGF administration is equally effective in aging animals. Eighteen-month-old rats received fimbrial transections and were given intraventricular injections of NGF during four weeks. Septal cholinergic neurons were then visualized using NGF receptor immunohistochemistry, which represents a reliable marker for cholinergic neurons in the septal area. The fimbrial transections reduced the number of septal NGF receptor-positive cells to a similar extent as in young animals. NGF treatment of aging rats protected these cells as effectively as in young adult rats.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>2628784</pmid><doi>10.1016/0197-4580(89)90011-0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neurobiology of aging, 1989, Vol.10 (6), p.739-743 |
| issn | 0197-4580 1558-1497 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aging Aging - drug effects Aging - pathology Alzheimer's disease Animals Biochemistry and metabolism Biological and medical sciences Cell Survival - drug effects Central nervous system Cholinergic neuron Female Fundamental and applied biological sciences. Psychology Hippocampus Injections, Intraventricular Nerve growth factor Nerve Growth Factors - administration & dosage Nerve Growth Factors - pharmacology Neuronal survival Neurons - cytology Neurons - drug effects NGF Rats Rats, Inbred Strains Septum Septum Pellucidum - cytology Septum Pellucidum - drug effects Vertebrates: nervous system and sense organs |
| title | Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats |
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