Lack of diurnal variation in plasma levels of androstenedione, testosterone, estrone and estradiol in postmenopausal women
Plasma 4-en-androstenedione, testosterone, estradiol and estrone were measured during the day in six healthy postmenopausal women and in six breast cancer patients, three of whom received treatment with glucocorticoids. Blood samples were obtained at 8a.m., 10 a.m., 12 noon, 4 p.m., 8 p.m. and 12 mi...
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| Veröffentlicht in: | Journal of steroid biochemistry 1989, Vol.34 (1), p.551-553 |
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| container_title | Journal of steroid biochemistry |
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| creator | Lønning, P.E. Dowsett, M. Jacobs, S. Schem, B. Hardy, J. Powles, T.J. |
| description | Plasma 4-en-androstenedione, testosterone, estradiol and estrone were measured during the day in six healthy postmenopausal women and in six breast cancer patients, three of whom received treatment with glucocorticoids. Blood samples were obtained at 8a.m., 10 a.m., 12 noon, 4 p.m., 8 p.m. and 12 midnight. There was a considerable variation in plasma levels of all steroids during the day; for 4-en-androstenedione the mean within patient coefficient variation was 61.4%, for testosterone it was 28.9%, for estrone it was 17.8% and for estradiol it was 29.2%. While the plasma levels for all steroids tended to be higher in the morning than in the evening, the changes were not statistically significant (Friedman's test:
P >0.10). We conclude that although a moderate diurnal variation in the plasma level of these steroids may occur, it is of a moderate magnitude compared to variations due to other causes. |
| doi_str_mv | 10.1016/0022-4731(89)90143-X |
| format | Article |
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P >0.10). We conclude that although a moderate diurnal variation in the plasma level of these steroids may occur, it is of a moderate magnitude compared to variations due to other causes.</description><identifier>ISSN: 0022-4731</identifier><identifier>DOI: 10.1016/0022-4731(89)90143-X</identifier><identifier>PMID: 2626050</identifier><identifier>CODEN: JSTBBK</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Androstenedione - blood ; Biological and medical sciences ; Breast Neoplasms - blood ; Circadian Rhythm ; Estradiol - blood ; Estrone - blood ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Menopause - blood ; Middle Aged ; Reference Values ; Testosterone - blood ; Tumors</subject><ispartof>Journal of steroid biochemistry, 1989, Vol.34 (1), p.551-553</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-b77344addf09a5e349ac69d0ead8b5256fa9db7e5dc82d345cb018cdae1999113</citedby><cites>FETCH-LOGICAL-c468t-b77344addf09a5e349ac69d0ead8b5256fa9db7e5dc82d345cb018cdae1999113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4010,4036,4037,23909,23910,25118,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6951131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2626050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lønning, P.E.</creatorcontrib><creatorcontrib>Dowsett, M.</creatorcontrib><creatorcontrib>Jacobs, S.</creatorcontrib><creatorcontrib>Schem, B.</creatorcontrib><creatorcontrib>Hardy, J.</creatorcontrib><creatorcontrib>Powles, T.J.</creatorcontrib><title>Lack of diurnal variation in plasma levels of androstenedione, testosterone, estrone and estradiol in postmenopausal women</title><title>Journal of steroid biochemistry</title><addtitle>J Steroid Biochem</addtitle><description>Plasma 4-en-androstenedione, testosterone, estradiol and estrone were measured during the day in six healthy postmenopausal women and in six breast cancer patients, three of whom received treatment with glucocorticoids. Blood samples were obtained at 8a.m., 10 a.m., 12 noon, 4 p.m., 8 p.m. and 12 midnight. There was a considerable variation in plasma levels of all steroids during the day; for 4-en-androstenedione the mean within patient coefficient variation was 61.4%, for testosterone it was 28.9%, for estrone it was 17.8% and for estradiol it was 29.2%. While the plasma levels for all steroids tended to be higher in the morning than in the evening, the changes were not statistically significant (Friedman's test:
P >0.10). We conclude that although a moderate diurnal variation in the plasma level of these steroids may occur, it is of a moderate magnitude compared to variations due to other causes.</description><subject>Androstenedione - blood</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - blood</subject><subject>Circadian Rhythm</subject><subject>Estradiol - blood</subject><subject>Estrone - blood</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Menopause - blood</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Testosterone - blood</subject><subject>Tumors</subject><issn>0022-4731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhnVoSdK0_yAFH0JJIU4lW7KlSyCEfgQWckkgNzGWxqBWljeSvSX99ZF3lz02J83HM6OZeQk5Y_SKUdZ8o7SqSt7W7EKqr4oyXpdP78jJIXxMPqT0m1KmJK-OyFHVVA0V9IT8W4H5U4x9Yd0cA_hiA9HB5MZQuFCsPaQBCo8b9GmhINg4pgkD2ozgZTFhmpZA3HrZWYwF29qQKb9tlJkBw7iGOeVP_o7Z-Uje9-ATftq_p-Txx_eH21_l6v7n3e3NqjS8kVPZtW3NOVjbUwUCa67ANMpSBCs7UYmmB2W7FoU1srI1F6ajTBoLyJRSjNWn5Muu7zqOz3MeSw8uGfQeAo5z0q3ismWVfBNkQrV1K3gG-Q40-RgpYq_X0Q0QXzSjetFDL4fXy-G1VHqrh37KZZ_3_eduQHso2ouR8-f7PCQDvo8QjEsHrFEib7Psc73Dsia4cRh1Mg6DyZJENJO2o_v_HK-zyquv</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Lønning, P.E.</creator><creator>Dowsett, M.</creator><creator>Jacobs, S.</creator><creator>Schem, B.</creator><creator>Hardy, J.</creator><creator>Powles, T.J.</creator><general>Elsevier B.V</general><general>Pergamon</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Lack of diurnal variation in plasma levels of androstenedione, testosterone, estrone and estradiol in postmenopausal women</title><author>Lønning, P.E. ; Dowsett, M. ; Jacobs, S. ; Schem, B. ; Hardy, J. ; Powles, T.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-b77344addf09a5e349ac69d0ead8b5256fa9db7e5dc82d345cb018cdae1999113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Androstenedione - blood</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - blood</topic><topic>Circadian Rhythm</topic><topic>Estradiol - blood</topic><topic>Estrone - blood</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Menopause - blood</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Testosterone - blood</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lønning, P.E.</creatorcontrib><creatorcontrib>Dowsett, M.</creatorcontrib><creatorcontrib>Jacobs, S.</creatorcontrib><creatorcontrib>Schem, B.</creatorcontrib><creatorcontrib>Hardy, J.</creatorcontrib><creatorcontrib>Powles, T.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of steroid biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lønning, P.E.</au><au>Dowsett, M.</au><au>Jacobs, S.</au><au>Schem, B.</au><au>Hardy, J.</au><au>Powles, T.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of diurnal variation in plasma levels of androstenedione, testosterone, estrone and estradiol in postmenopausal women</atitle><jtitle>Journal of steroid biochemistry</jtitle><addtitle>J Steroid Biochem</addtitle><date>1989</date><risdate>1989</risdate><volume>34</volume><issue>1</issue><spage>551</spage><epage>553</epage><pages>551-553</pages><issn>0022-4731</issn><coden>JSTBBK</coden><abstract>Plasma 4-en-androstenedione, testosterone, estradiol and estrone were measured during the day in six healthy postmenopausal women and in six breast cancer patients, three of whom received treatment with glucocorticoids. Blood samples were obtained at 8a.m., 10 a.m., 12 noon, 4 p.m., 8 p.m. and 12 midnight. There was a considerable variation in plasma levels of all steroids during the day; for 4-en-androstenedione the mean within patient coefficient variation was 61.4%, for testosterone it was 28.9%, for estrone it was 17.8% and for estradiol it was 29.2%. While the plasma levels for all steroids tended to be higher in the morning than in the evening, the changes were not statistically significant (Friedman's test:
P >0.10). We conclude that although a moderate diurnal variation in the plasma level of these steroids may occur, it is of a moderate magnitude compared to variations due to other causes.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2626050</pmid><doi>10.1016/0022-4731(89)90143-X</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of steroid biochemistry, 1989, Vol.34 (1), p.551-553 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Androstenedione - blood Biological and medical sciences Breast Neoplasms - blood Circadian Rhythm Estradiol - blood Estrone - blood Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Menopause - blood Middle Aged Reference Values Testosterone - blood Tumors |
| title | Lack of diurnal variation in plasma levels of androstenedione, testosterone, estrone and estradiol in postmenopausal women |
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