Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro
Intracellular recordings were performed to study the effects of 5-HT on membrane properties and EPSP/IPSP responses of subicular neurons in rat combined hippocampal-entorhinal cortex slices. Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of...
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| Veröffentlicht in: | Brain research 1997-10, Vol.773 (1), p.217-222 |
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| creator | Behr, J Empson, R.M Schmitz, D Gloveli, T Heinemann, U |
| description | Intracellular recordings were performed to study the effects of 5-HT on membrane properties and EPSP/IPSP responses of subicular neurons in rat combined hippocampal-entorhinal cortex slices. Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of membrane resistance. In bursting neurons, 5-HT caused a reduction of the depolarizing envelope underlying burst discharges and attenuated the subsequent afterhyperpolarization. While 5-HT decreased isolated AMPA/kainate and NMDA receptor-mediated responses as well as slow IPSPs, we could not find a consistent effect on isolated fast IPSPs. Since in ≈25% of subicular neurons EPSPs and slow IPSPs were reduced without any increase of membrane conductance, we conclude that 5-HT has in addition to membrane effects also effects on synaptic currents. |
| doi_str_mv | 10.1016/S0006-8993(97)00939-6 |
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Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of membrane resistance. In bursting neurons, 5-HT caused a reduction of the depolarizing envelope underlying burst discharges and attenuated the subsequent afterhyperpolarization. While 5-HT decreased isolated AMPA/kainate and NMDA receptor-mediated responses as well as slow IPSPs, we could not find a consistent effect on isolated fast IPSPs. Since in ≈25% of subicular neurons EPSPs and slow IPSPs were reduced without any increase of membrane conductance, we conclude that 5-HT has in addition to membrane effects also effects on synaptic currents.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(97)00939-6</identifier><identifier>PMID: 9409725</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>5-HT ; AMPA ; Animals ; Bursting cell ; Entorhinal Cortex - drug effects ; Entorhinal Cortex - physiology ; Evoked Potentials - drug effects ; Evoked Potentials - physiology ; Excitatory Amino Acid Antagonists - pharmacology ; Excitatory Postsynaptic Potentials - drug effects ; Excitatory Postsynaptic Potentials - physiology ; GABA A ; GABA Antagonists - pharmacology ; GABA B ; Hippocampus - drug effects ; Hippocampus - physiology ; In Vitro Techniques ; Intracellular recording ; Neurons - drug effects ; Neurons - physiology ; NMDA ; Phosphinic Acids - pharmacology ; Propanolamines - pharmacology ; Quinoxalines - pharmacology ; Rats ; Rats, Wistar ; Regular firing cell ; Serotonin - pharmacology ; Subiculum ; Synapses - drug effects ; Synapses - physiology</subject><ispartof>Brain research, 1997-10, Vol.773 (1), p.217-222</ispartof><rights>1997 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-76a7b00e6f4c74b7e949e8f4f83bf9f3f994ee18fd10baaba6f96513843781aa3</citedby><cites>FETCH-LOGICAL-c457t-76a7b00e6f4c74b7e949e8f4f83bf9f3f994ee18fd10baaba6f96513843781aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(97)00939-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9409725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Behr, J</creatorcontrib><creatorcontrib>Empson, R.M</creatorcontrib><creatorcontrib>Schmitz, D</creatorcontrib><creatorcontrib>Gloveli, T</creatorcontrib><creatorcontrib>Heinemann, U</creatorcontrib><title>Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Intracellular recordings were performed to study the effects of 5-HT on membrane properties and EPSP/IPSP responses of subicular neurons in rat combined hippocampal-entorhinal cortex slices. Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of membrane resistance. In bursting neurons, 5-HT caused a reduction of the depolarizing envelope underlying burst discharges and attenuated the subsequent afterhyperpolarization. While 5-HT decreased isolated AMPA/kainate and NMDA receptor-mediated responses as well as slow IPSPs, we could not find a consistent effect on isolated fast IPSPs. Since in ≈25% of subicular neurons EPSPs and slow IPSPs were reduced without any increase of membrane conductance, we conclude that 5-HT has in addition to membrane effects also effects on synaptic currents.</description><subject>5-HT</subject><subject>AMPA</subject><subject>Animals</subject><subject>Bursting cell</subject><subject>Entorhinal Cortex - drug effects</subject><subject>Entorhinal Cortex - physiology</subject><subject>Evoked Potentials - drug effects</subject><subject>Evoked Potentials - physiology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>Excitatory Postsynaptic Potentials - physiology</subject><subject>GABA A</subject><subject>GABA Antagonists - pharmacology</subject><subject>GABA B</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>In Vitro Techniques</subject><subject>Intracellular recording</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>NMDA</subject><subject>Phosphinic Acids - pharmacology</subject><subject>Propanolamines - pharmacology</subject><subject>Quinoxalines - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regular firing cell</subject><subject>Serotonin - pharmacology</subject><subject>Subiculum</subject><subject>Synapses - drug effects</subject><subject>Synapses - physiology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LRCEUhiWKmj5-QuAqanFLr169riJi-oCgRbVqIV7vEYwZndQb9O-zmaFtq8PhPO858ojQKSWXlFBx9UIIEU2vFDtX8oIQxVQjdtCM9rJtRMvJLpr9IQfoMOeP2jKmyD7aV5wo2XYz9D53DmzJODqcIcUSgw84Bpy_g1kVb7EJI_ahJB9y7VYpriAVD-tEMgXnafB2WpiEA0wphlxp_OVLisdoz5lFhpNtPUJvd_PX24fm6fn-8fbmqbG8k6WRwsiBEBCOW8kHCYor6B13PRuccswpxQFo70ZKBmMGI5wSHWU9Z7KnxrAjdLbZWx_3OUEueumzhcXCBIhT1lLxXnRd-y9IRUtlx2gFuw1oU8w5gdOr5JcmfWtK9K99vbavf9VqJfXavhY1d7o9MA1LGP9SW911fr2ZQ9Xx5SHpbD0EC6NP9Rf0GP0_F34AodKV1A</recordid><startdate>19971031</startdate><enddate>19971031</enddate><creator>Behr, J</creator><creator>Empson, R.M</creator><creator>Schmitz, D</creator><creator>Gloveli, T</creator><creator>Heinemann, U</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19971031</creationdate><title>Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro</title><author>Behr, J ; Empson, R.M ; Schmitz, D ; Gloveli, T ; Heinemann, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-76a7b00e6f4c74b7e949e8f4f83bf9f3f994ee18fd10baaba6f96513843781aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>5-HT</topic><topic>AMPA</topic><topic>Animals</topic><topic>Bursting cell</topic><topic>Entorhinal Cortex - drug effects</topic><topic>Entorhinal Cortex - physiology</topic><topic>Evoked Potentials - drug effects</topic><topic>Evoked Potentials - physiology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Excitatory Postsynaptic Potentials - drug effects</topic><topic>Excitatory Postsynaptic Potentials - physiology</topic><topic>GABA A</topic><topic>GABA Antagonists - pharmacology</topic><topic>GABA B</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>Intracellular recording</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>NMDA</topic><topic>Phosphinic Acids - pharmacology</topic><topic>Propanolamines - pharmacology</topic><topic>Quinoxalines - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regular firing cell</topic><topic>Serotonin - pharmacology</topic><topic>Subiculum</topic><topic>Synapses - drug effects</topic><topic>Synapses - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Behr, J</creatorcontrib><creatorcontrib>Empson, R.M</creatorcontrib><creatorcontrib>Schmitz, D</creatorcontrib><creatorcontrib>Gloveli, T</creatorcontrib><creatorcontrib>Heinemann, U</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Behr, J</au><au>Empson, R.M</au><au>Schmitz, D</au><au>Gloveli, T</au><au>Heinemann, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1997-10-31</date><risdate>1997</risdate><volume>773</volume><issue>1</issue><spage>217</spage><epage>222</epage><pages>217-222</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Intracellular recordings were performed to study the effects of 5-HT on membrane properties and EPSP/IPSP responses of subicular neurons in rat combined hippocampal-entorhinal cortex slices. Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of membrane resistance. In bursting neurons, 5-HT caused a reduction of the depolarizing envelope underlying burst discharges and attenuated the subsequent afterhyperpolarization. While 5-HT decreased isolated AMPA/kainate and NMDA receptor-mediated responses as well as slow IPSPs, we could not find a consistent effect on isolated fast IPSPs. Since in ≈25% of subicular neurons EPSPs and slow IPSPs were reduced without any increase of membrane conductance, we conclude that 5-HT has in addition to membrane effects also effects on synaptic currents.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9409725</pmid><doi>10.1016/S0006-8993(97)00939-6</doi><tpages>6</tpages></addata></record> |
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| subjects | 5-HT AMPA Animals Bursting cell Entorhinal Cortex - drug effects Entorhinal Cortex - physiology Evoked Potentials - drug effects Evoked Potentials - physiology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology GABA A GABA Antagonists - pharmacology GABA B Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Intracellular recording Neurons - drug effects Neurons - physiology NMDA Phosphinic Acids - pharmacology Propanolamines - pharmacology Quinoxalines - pharmacology Rats Rats, Wistar Regular firing cell Serotonin - pharmacology Subiculum Synapses - drug effects Synapses - physiology |
| title | Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro |
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