Neurofibrillary degeneration and neuronal loss in alzheimer's disease
Neuronal loss in Alzheimer's disease, especially in cerebral cortex and hippocampus, appears closely associated with the process of neurofibrillary degeneration. In certain noncortical nuclei neuronal loss appears not to depend upon the formation of neurofibrillary tangles. Neurofibrillary tang...
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| Veröffentlicht in: | Neurobiology of aging 1989-11, Vol.10 (6), p.709-715 |
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| container_title | Neurobiology of aging |
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| creator | Bondareff, William Mountjoy, C.Q. Roth, M. Hauser, D.L. |
| description | Neuronal loss in Alzheimer's disease, especially in cerebral cortex and hippocampus, appears closely associated with the process of neurofibrillary degeneration. In certain noncortical nuclei neuronal loss appears not to depend upon the formation of neurofibrillary tangles. Neurofibrillary tangles and neurons were counted in the same populations of neurons in five brain regions. In the locus ceruleus and nucleus basalis, where tangles have a loose or globose structure, correlations with neuronal counts were not significant. In cerebral cortex and hippocampus, tangles have a more dense and often a flame-like appearance and their correlations with neuronal counts were significant. The relationships between tangles and noncortical neurons reported here suggest that the appearance of tangles does not necessarily herald the demise of a neuron in Alzheimer's disease. It can be reasonably anticipated that these relationships depend upon the clinical heterogeneity of Alzheimer's disease, regional differences in the brain and/or the macromolecular composition of neurofibrillary tangles. |
| doi_str_mv | 10.1016/0197-4580(89)90007-9 |
| format | Article |
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In certain noncortical nuclei neuronal loss appears not to depend upon the formation of neurofibrillary tangles. Neurofibrillary tangles and neurons were counted in the same populations of neurons in five brain regions. In the locus ceruleus and nucleus basalis, where tangles have a loose or globose structure, correlations with neuronal counts were not significant. In cerebral cortex and hippocampus, tangles have a more dense and often a flame-like appearance and their correlations with neuronal counts were significant. The relationships between tangles and noncortical neurons reported here suggest that the appearance of tangles does not necessarily herald the demise of a neuron in Alzheimer's disease. 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In certain noncortical nuclei neuronal loss appears not to depend upon the formation of neurofibrillary tangles. Neurofibrillary tangles and neurons were counted in the same populations of neurons in five brain regions. In the locus ceruleus and nucleus basalis, where tangles have a loose or globose structure, correlations with neuronal counts were not significant. In cerebral cortex and hippocampus, tangles have a more dense and often a flame-like appearance and their correlations with neuronal counts were significant. The relationships between tangles and noncortical neurons reported here suggest that the appearance of tangles does not necessarily herald the demise of a neuron in Alzheimer's disease. It can be reasonably anticipated that these relationships depend upon the clinical heterogeneity of Alzheimer's disease, regional differences in the brain and/or the macromolecular composition of neurofibrillary tangles.</description><subject>Aged</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Cell Count</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - pathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Locus ceruleus</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Degeneration</subject><subject>Neurofibrillary degeneration</subject><subject>Neurofibrillary tangles</subject><subject>Neurofibrils - pathology</subject><subject>Neurology</subject><subject>Neuronal degeneration</subject><subject>Neurons - pathology</subject><subject>Nucleus basalis</subject><subject>Statistics as Topic</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKBDEQRYMoOj7-QKE3vhatqe48N4KILxh0o-uQSao10tOtyYygX2_aGXSnq0Dq3EvVIWQX6AlQEKcUtCwZV_RI6WNNKZWlXiEj4FyVwLRcJaMfZINspvQyMEyKdbJeiUpJVY3I5R3OY9-ESQxta-NH4fEJO4x2FvqusJ0vugHobFu0fUpFyJ_t5zOGKcbDVPiQ0CbcJmuNbRPuLN8t8nh1-XBxU47vr28vzselY6BmJRcNr72tnVQT0UjPLQXlGvDg0TnrvUKsvKpAMMV4DRosZcJqLmumQPh6ixwsel9j_zbHNDPTkBzmzTvs58lInYNSwr9glqQFUJZBtgBdzOdFbMxrDNMswgA1g2YzODSDQ6O0-dZsdI7tLfvnkyn6n9DSa57vL-c2Ods20XYupN9uXXEu1NBztuAwW3sPGE1yATuHPkR0M-P78PciX845mN8</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Bondareff, William</creator><creator>Mountjoy, C.Q.</creator><creator>Roth, M.</creator><creator>Hauser, D.L.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19891101</creationdate><title>Neurofibrillary degeneration and neuronal loss in alzheimer's disease</title><author>Bondareff, William ; Mountjoy, C.Q. ; Roth, M. ; Hauser, D.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-56f53da3c78b6f7d5a018cf1d1deccadd8ee2d821648453191a046a95734816d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aged</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Cell Count</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - pathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Locus ceruleus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Degeneration</topic><topic>Neurofibrillary degeneration</topic><topic>Neurofibrillary tangles</topic><topic>Neurofibrils - pathology</topic><topic>Neurology</topic><topic>Neuronal degeneration</topic><topic>Neurons - pathology</topic><topic>Nucleus basalis</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bondareff, William</creatorcontrib><creatorcontrib>Mountjoy, C.Q.</creatorcontrib><creatorcontrib>Roth, M.</creatorcontrib><creatorcontrib>Hauser, D.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bondareff, William</au><au>Mountjoy, C.Q.</au><au>Roth, M.</au><au>Hauser, D.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurofibrillary degeneration and neuronal loss in alzheimer's disease</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>10</volume><issue>6</issue><spage>709</spage><epage>715</epage><pages>709-715</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Neuronal loss in Alzheimer's disease, especially in cerebral cortex and hippocampus, appears closely associated with the process of neurofibrillary degeneration. In certain noncortical nuclei neuronal loss appears not to depend upon the formation of neurofibrillary tangles. Neurofibrillary tangles and neurons were counted in the same populations of neurons in five brain regions. In the locus ceruleus and nucleus basalis, where tangles have a loose or globose structure, correlations with neuronal counts were not significant. In cerebral cortex and hippocampus, tangles have a more dense and often a flame-like appearance and their correlations with neuronal counts were significant. The relationships between tangles and noncortical neurons reported here suggest that the appearance of tangles does not necessarily herald the demise of a neuron in Alzheimer's disease. It can be reasonably anticipated that these relationships depend upon the clinical heterogeneity of Alzheimer's disease, regional differences in the brain and/or the macromolecular composition of neurofibrillary tangles.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>2628782</pmid><doi>10.1016/0197-4580(89)90007-9</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Brain - pathology Cell Count Cerebral cortex Cerebral Cortex - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Hippocampus Histopathology Humans Locus ceruleus Male Medical sciences Nerve Degeneration Neurofibrillary degeneration Neurofibrillary tangles Neurofibrils - pathology Neurology Neuronal degeneration Neurons - pathology Nucleus basalis Statistics as Topic |
| title | Neurofibrillary degeneration and neuronal loss in alzheimer's disease |
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