Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes
The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L indu...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 1997-11, Vol.417 (3), p.301-306 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 306 |
|---|---|
| container_issue | 3 |
| container_start_page | 301 |
| container_title | FEBS letters |
| container_volume | 417 |
| creator | Brenner, Birgit Koppenhoefer, Ursula Grassmé, Heike Kun, Jutta Lang, Florian Gulbins, Erich |
| description | The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates with a stimulation of Rac1 and inhibition of Rac1 prevents gp39/CD40L triggered JNK/p38-K activation. Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56
lck. Inhibition of src-like kinases inhibits Rac1 as well as JNK/p38-K stimulation suggesting a signalling cascade from the gp39/CD40L via p56
lck and Rac1 to JNK/p38-K. |
| doi_str_mv | 10.1016/S0014-5793(97)01306-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79484613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014579397013069</els_id><sourcerecordid>79484613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4049-e9e44c722281429bb1f554ac48da31b2b43e6639f1bb355beb358f44d2d716e13</originalsourceid><addsrcrecordid>eNqNkc1O6zAQhS0EgvLzCEheIe4iYMdOHK_QvaUFJCQWwIaN5TiTYuTYvXFS1LcnaSu2sPHIPmfOWN8gdE7JFSU0v34mhPIkE5JdSvGHUEbyRO6hCS0ESxjPi300-bYcoeMYP8hwL6g8RIeSEylYMUFvs5WtwBvAdWixxj6swOG696azweNQ4-4d8PSWE-zsQvsK6zjYol147Zz1C9wEB6Z3gK3HL4lbN8v3YNYdxFN0UGsX4WxXT9DrfPYyvU8en-4epn8fE8MJlwlI4NyINE0LylNZlrTOMq4NLyrNaJmWnEGeM1nTsmRZVsJwFjXnVVoJmgNlJ-him7tsw_8eYqcaGw04pz2EPiohecFzygZjtjWaNsTYQq2WrW10u1aUqJGp2jBVIzAlhdowVXLoO98N6MsGqu-uHcRBv9_qn9bB-nehaj77l26UUZBi8zyOutlGwQBsZaFV0dhxPZVtwXSqCvaHz34BIEGZAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79484613</pqid></control><display><type>article</type><title>Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Brenner, Birgit ; Koppenhoefer, Ursula ; Grassmé, Heike ; Kun, Jutta ; Lang, Florian ; Gulbins, Erich</creator><creatorcontrib>Brenner, Birgit ; Koppenhoefer, Ursula ; Grassmé, Heike ; Kun, Jutta ; Lang, Florian ; Gulbins, Erich</creatorcontrib><description>The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates with a stimulation of Rac1 and inhibition of Rac1 prevents gp39/CD40L triggered JNK/p38-K activation. Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56
lck. Inhibition of src-like kinases inhibits Rac1 as well as JNK/p38-K stimulation suggesting a signalling cascade from the gp39/CD40L via p56
lck and Rac1 to JNK/p38-K.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(97)01306-9</identifier><identifier>PMID: 9409738</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Antigens, CD - physiology ; Calcium-Calmodulin-Dependent Protein Kinases - metabolism ; CD40 Antigens - physiology ; CD40 Ligand ; gp39 ; Humans ; JNK Mitogen-Activated Protein Kinases ; Jun-N-terminal kinase ; Jurkat Cells ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism ; Membrane Glycoproteins - physiology ; Mice ; Mitogen-Activated Protein Kinases ; p38 Mitogen-Activated Protein Kinases ; Recombinant Proteins - metabolism ; Signal Transduction ; Spleen - enzymology ; T-lymphocytes ; T-Lymphocytes - immunology ; T-Lymphocytes - physiology ; Transfection ; Tyrosine kinase</subject><ispartof>FEBS letters, 1997-11, Vol.417 (3), p.301-306</ispartof><rights>1997 Federation of European Biochemical Societies</rights><rights>FEBS Letters 417 (1997) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4049-e9e44c722281429bb1f554ac48da31b2b43e6639f1bb355beb358f44d2d716e13</citedby><cites>FETCH-LOGICAL-c4049-e9e44c722281429bb1f554ac48da31b2b43e6639f1bb355beb358f44d2d716e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2897%2901306-9$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-5793(97)01306-9$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,3550,27924,27925,45574,45575,45995,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9409738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brenner, Birgit</creatorcontrib><creatorcontrib>Koppenhoefer, Ursula</creatorcontrib><creatorcontrib>Grassmé, Heike</creatorcontrib><creatorcontrib>Kun, Jutta</creatorcontrib><creatorcontrib>Lang, Florian</creatorcontrib><creatorcontrib>Gulbins, Erich</creatorcontrib><title>Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates with a stimulation of Rac1 and inhibition of Rac1 prevents gp39/CD40L triggered JNK/p38-K activation. Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56
lck. Inhibition of src-like kinases inhibits Rac1 as well as JNK/p38-K stimulation suggesting a signalling cascade from the gp39/CD40L via p56
lck and Rac1 to JNK/p38-K.</description><subject>Animals</subject><subject>Antigens, CD - physiology</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</subject><subject>CD40 Antigens - physiology</subject><subject>CD40 Ligand</subject><subject>gp39</subject><subject>Humans</subject><subject>JNK Mitogen-Activated Protein Kinases</subject><subject>Jun-N-terminal kinase</subject><subject>Jurkat Cells</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Mice</subject><subject>Mitogen-Activated Protein Kinases</subject><subject>p38 Mitogen-Activated Protein Kinases</subject><subject>Recombinant Proteins - metabolism</subject><subject>Signal Transduction</subject><subject>Spleen - enzymology</subject><subject>T-lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - physiology</subject><subject>Transfection</subject><subject>Tyrosine kinase</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1O6zAQhS0EgvLzCEheIe4iYMdOHK_QvaUFJCQWwIaN5TiTYuTYvXFS1LcnaSu2sPHIPmfOWN8gdE7JFSU0v34mhPIkE5JdSvGHUEbyRO6hCS0ESxjPi300-bYcoeMYP8hwL6g8RIeSEylYMUFvs5WtwBvAdWixxj6swOG696azweNQ4-4d8PSWE-zsQvsK6zjYol147Zz1C9wEB6Z3gK3HL4lbN8v3YNYdxFN0UGsX4WxXT9DrfPYyvU8en-4epn8fE8MJlwlI4NyINE0LylNZlrTOMq4NLyrNaJmWnEGeM1nTsmRZVsJwFjXnVVoJmgNlJ-him7tsw_8eYqcaGw04pz2EPiohecFzygZjtjWaNsTYQq2WrW10u1aUqJGp2jBVIzAlhdowVXLoO98N6MsGqu-uHcRBv9_qn9bB-nehaj77l26UUZBi8zyOutlGwQBsZaFV0dhxPZVtwXSqCvaHz34BIEGZAw</recordid><startdate>19971117</startdate><enddate>19971117</enddate><creator>Brenner, Birgit</creator><creator>Koppenhoefer, Ursula</creator><creator>Grassmé, Heike</creator><creator>Kun, Jutta</creator><creator>Lang, Florian</creator><creator>Gulbins, Erich</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971117</creationdate><title>Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes</title><author>Brenner, Birgit ; Koppenhoefer, Ursula ; Grassmé, Heike ; Kun, Jutta ; Lang, Florian ; Gulbins, Erich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4049-e9e44c722281429bb1f554ac48da31b2b43e6639f1bb355beb358f44d2d716e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antigens, CD - physiology</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</topic><topic>CD40 Antigens - physiology</topic><topic>CD40 Ligand</topic><topic>gp39</topic><topic>Humans</topic><topic>JNK Mitogen-Activated Protein Kinases</topic><topic>Jun-N-terminal kinase</topic><topic>Jurkat Cells</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Mice</topic><topic>Mitogen-Activated Protein Kinases</topic><topic>p38 Mitogen-Activated Protein Kinases</topic><topic>Recombinant Proteins - metabolism</topic><topic>Signal Transduction</topic><topic>Spleen - enzymology</topic><topic>T-lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - physiology</topic><topic>Transfection</topic><topic>Tyrosine kinase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brenner, Birgit</creatorcontrib><creatorcontrib>Koppenhoefer, Ursula</creatorcontrib><creatorcontrib>Grassmé, Heike</creatorcontrib><creatorcontrib>Kun, Jutta</creatorcontrib><creatorcontrib>Lang, Florian</creatorcontrib><creatorcontrib>Gulbins, Erich</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brenner, Birgit</au><au>Koppenhoefer, Ursula</au><au>Grassmé, Heike</au><au>Kun, Jutta</au><au>Lang, Florian</au><au>Gulbins, Erich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1997-11-17</date><risdate>1997</risdate><volume>417</volume><issue>3</issue><spage>301</spage><epage>306</epage><pages>301-306</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates with a stimulation of Rac1 and inhibition of Rac1 prevents gp39/CD40L triggered JNK/p38-K activation. Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56
lck. Inhibition of src-like kinases inhibits Rac1 as well as JNK/p38-K stimulation suggesting a signalling cascade from the gp39/CD40L via p56
lck and Rac1 to JNK/p38-K.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>9409738</pmid><doi>10.1016/S0014-5793(97)01306-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1997-11, Vol.417 (3), p.301-306 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79484613 |
| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antigens, CD - physiology Calcium-Calmodulin-Dependent Protein Kinases - metabolism CD40 Antigens - physiology CD40 Ligand gp39 Humans JNK Mitogen-Activated Protein Kinases Jun-N-terminal kinase Jurkat Cells Lymphocyte Activation Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Membrane Glycoproteins - physiology Mice Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases Recombinant Proteins - metabolism Signal Transduction Spleen - enzymology T-lymphocytes T-Lymphocytes - immunology T-Lymphocytes - physiology Transfection Tyrosine kinase |
| title | Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T11%3A23%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evidence%20for%20a%20novel%20function%20of%20the%20CD40%20ligand%20as%20a%20signalling%20molecule%20in%20T-lymphocytes&rft.jtitle=FEBS%20letters&rft.au=Brenner,%20Birgit&rft.date=1997-11-17&rft.volume=417&rft.issue=3&rft.spage=301&rft.epage=306&rft.pages=301-306&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/S0014-5793(97)01306-9&rft_dat=%3Cproquest_cross%3E79484613%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79484613&rft_id=info:pmid/9409738&rft_els_id=S0014579397013069&rfr_iscdi=true |