Two Intracellular Signaling Pathways for Activation of Protein Kinase C Are Involved in Oxidized Low-Density Lipoprotein-Induced Macrophage Growth

Recent studies demonstrated that oxidized LDL (Ox-LDL) induces macrophage growth in vitro. The present study was undertaken to elucidate the intracellular signaling pathways for macrophage growth. Ox-LDL initiated a rapid and transient rise in intracellular free calcium ion and induced activation of...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1997-11, Vol.17 (11), p.3013-3020
Hauptverfasser:	Matsumura, Takeshi, Sakai, Masakazu, Kobori, Shozo, Biwa, Takeshi, Takemura, Toru, Matsuda, Hirofumi, Hakamata, Hideki, Horiuchi, Seikoh, Shichiri, Motoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Calcium - physiology Cardiology. Vascular system Cell Division - drug effects DNA Replication - drug effects Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology GTP-Binding Proteins - antagonists & inhibitors GTP-Binding Proteins - physiology Lipids - analysis Lipoproteins, LDL - chemistry Lipoproteins, LDL - drug effects Lipoproteins, LDL - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - enzymology Male Medical sciences Mice Mice, Inbred C3H Naphthalenes - pharmacology Pertussis Toxin Phospholipases A - pharmacology Phospholipases A2 Protein Kinase C - metabolism Signal Transduction - physiology Virulence Factors, Bordetella - pharmacology
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