Quantitative Evaluation of Recurrent Meningiomas
Clinical, histological and karyometric parameters, nuclear DNA content and the number of nucleolar organizer regions were investigated in 9 recurrent meningiomas and 10 meningiomas which had not recurred within a 10-year period. There were no significant differences between the two groups as to age,...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 1989-11, Vol.185 (5), p.746-751 |
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| container_title | Pathology, research and practice |
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| creator | Scarpelli, M. Montironi, R. Sisti, S. Mariuzzi, G.M. Brancorsini, D. Collan, Y. Rychlicki, F. Ansuini, G. |
| description | Clinical, histological and karyometric parameters, nuclear DNA content and the number of nucleolar organizer regions were investigated in 9 recurrent meningiomas and 10 meningiomas which had not recurred within a 10-year period. There were no significant differences between the two groups as to age, sex, site of the tumours and most of the histological parameters scored. Recurrent tumours showed a higher number of mitotic figures and the nucleolus was visible in most of the cells. Cell density, nuclear area, perimeter and nuclear DNA content had values with no statistically significant differences between the two groups. However, significant differences were found in the distribution of the nuclei in the different ploidy regions. Most ofthe nuclei in the non recurrent cases were in the diploid range, whereas in recurrent tumours there was a reduction in the number of diploid cells associated with an increase in 2c–4c and 4c components Recurrent tumours also showed a higher number of nucleolar organizer regions positively stained using an argyrophil method. The mitotic count and the nucleolar organizer regions appeared to be the best predictors for recurrence. |
| doi_str_mv | 10.1016/S0344-0338(89)80231-6 |
| format | Article |
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There were no significant differences between the two groups as to age, sex, site of the tumours and most of the histological parameters scored. Recurrent tumours showed a higher number of mitotic figures and the nucleolus was visible in most of the cells. Cell density, nuclear area, perimeter and nuclear DNA content had values with no statistically significant differences between the two groups. However, significant differences were found in the distribution of the nuclei in the different ploidy regions. Most ofthe nuclei in the non recurrent cases were in the diploid range, whereas in recurrent tumours there was a reduction in the number of diploid cells associated with an increase in 2c–4c and 4c components Recurrent tumours also showed a higher number of nucleolar organizer regions positively stained using an argyrophil method. The mitotic count and the nucleolar organizer regions appeared to be the best predictors for recurrence.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/S0344-0338(89)80231-6</identifier><identifier>PMID: 2626384</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Aged ; DNA content ; DNA, Neoplasm - analysis ; DNA, Neoplasm - genetics ; Female ; Humans ; Male ; Meningeal Neoplasms - genetics ; Meningeal Neoplasms - pathology ; Meningioma - genetics ; Meningioma - pathology ; Middle Aged ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Nucleolar organizer regions ; Nucleolus Organizer Region ; Ploidies ; Quantitative pathology ; Recurrent meningiomas</subject><ispartof>Pathology, research and practice, 1989-11, Vol.185 (5), p.746-751</ispartof><rights>1989 Gustav Fischer Verlag · Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-4b34f324e10f71069f41863af6dfb395746fb6a456b582cd2ffdbc621da1303b3</citedby><cites>FETCH-LOGICAL-c360t-4b34f324e10f71069f41863af6dfb395746fb6a456b582cd2ffdbc621da1303b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0344-0338(89)80231-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2626384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scarpelli, M.</creatorcontrib><creatorcontrib>Montironi, R.</creatorcontrib><creatorcontrib>Sisti, S.</creatorcontrib><creatorcontrib>Mariuzzi, G.M.</creatorcontrib><creatorcontrib>Brancorsini, D.</creatorcontrib><creatorcontrib>Collan, Y.</creatorcontrib><creatorcontrib>Rychlicki, F.</creatorcontrib><creatorcontrib>Ansuini, G.</creatorcontrib><title>Quantitative Evaluation of Recurrent Meningiomas</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Clinical, histological and karyometric parameters, nuclear DNA content and the number of nucleolar organizer regions were investigated in 9 recurrent meningiomas and 10 meningiomas which had not recurred within a 10-year period. There were no significant differences between the two groups as to age, sex, site of the tumours and most of the histological parameters scored. Recurrent tumours showed a higher number of mitotic figures and the nucleolus was visible in most of the cells. Cell density, nuclear area, perimeter and nuclear DNA content had values with no statistically significant differences between the two groups. However, significant differences were found in the distribution of the nuclei in the different ploidy regions. Most ofthe nuclei in the non recurrent cases were in the diploid range, whereas in recurrent tumours there was a reduction in the number of diploid cells associated with an increase in 2c–4c and 4c components Recurrent tumours also showed a higher number of nucleolar organizer regions positively stained using an argyrophil method. The mitotic count and the nucleolar organizer regions appeared to be the best predictors for recurrence.</description><subject>Adult</subject><subject>Aged</subject><subject>DNA content</subject><subject>DNA, Neoplasm - analysis</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Meningeal Neoplasms - genetics</subject><subject>Meningeal Neoplasms - pathology</subject><subject>Meningioma - genetics</subject><subject>Meningioma - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Nucleolar organizer regions</subject><subject>Nucleolus Organizer Region</subject><subject>Ploidies</subject><subject>Quantitative pathology</subject><subject>Recurrent meningiomas</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EKqXwEyrlhOAQ2I0d1zkhVJWHVIR4nS3HWSOjNil2Uol_T_oQV0670szsaD_GxghXCCiv34ALkQLn6kIVlwoyjqk8YEOUqFKQHA_Z8M9yzE5i_AKACQgcsEEmM8mVGDJ46Uzd-ta0fk3JbG0WXb82ddK45JVsFwLVbfJEta8_fbM08ZQdObOIdLafI_ZxN3ufPqTz5_vH6e08tVxCm4qSC8czQQhugiALJ1BJbpysXMmLfCKkK6URuSxzldkqc64qrcywMsiBl3zEznd3V6H57ii2eumjpcXC1NR0UU8KoZAL7I35zmhDE2Mgp1fBL0340Qh6Q0pvSekNBq0KvSWlZZ8b7wu6cknVX2qPptdvdjr1X649BR2tp9pS5QPZVleN_6fhF19rd2k</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Scarpelli, M.</creator><creator>Montironi, R.</creator><creator>Sisti, S.</creator><creator>Mariuzzi, G.M.</creator><creator>Brancorsini, D.</creator><creator>Collan, Y.</creator><creator>Rychlicki, F.</creator><creator>Ansuini, G.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19891101</creationdate><title>Quantitative Evaluation of Recurrent Meningiomas</title><author>Scarpelli, M. ; Montironi, R. ; Sisti, S. ; Mariuzzi, G.M. ; Brancorsini, D. ; Collan, Y. ; Rychlicki, F. ; Ansuini, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-4b34f324e10f71069f41863af6dfb395746fb6a456b582cd2ffdbc621da1303b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>DNA content</topic><topic>DNA, Neoplasm - analysis</topic><topic>DNA, Neoplasm - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Meningeal Neoplasms - genetics</topic><topic>Meningeal Neoplasms - pathology</topic><topic>Meningioma - genetics</topic><topic>Meningioma - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Nucleolar organizer regions</topic><topic>Nucleolus Organizer Region</topic><topic>Ploidies</topic><topic>Quantitative pathology</topic><topic>Recurrent meningiomas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scarpelli, M.</creatorcontrib><creatorcontrib>Montironi, R.</creatorcontrib><creatorcontrib>Sisti, S.</creatorcontrib><creatorcontrib>Mariuzzi, G.M.</creatorcontrib><creatorcontrib>Brancorsini, D.</creatorcontrib><creatorcontrib>Collan, Y.</creatorcontrib><creatorcontrib>Rychlicki, F.</creatorcontrib><creatorcontrib>Ansuini, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scarpelli, M.</au><au>Montironi, R.</au><au>Sisti, S.</au><au>Mariuzzi, G.M.</au><au>Brancorsini, D.</au><au>Collan, Y.</au><au>Rychlicki, F.</au><au>Ansuini, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Evaluation of Recurrent Meningiomas</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>185</volume><issue>5</issue><spage>746</spage><epage>751</epage><pages>746-751</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>Clinical, histological and karyometric parameters, nuclear DNA content and the number of nucleolar organizer regions were investigated in 9 recurrent meningiomas and 10 meningiomas which had not recurred within a 10-year period. There were no significant differences between the two groups as to age, sex, site of the tumours and most of the histological parameters scored. Recurrent tumours showed a higher number of mitotic figures and the nucleolus was visible in most of the cells. Cell density, nuclear area, perimeter and nuclear DNA content had values with no statistically significant differences between the two groups. However, significant differences were found in the distribution of the nuclei in the different ploidy regions. Most ofthe nuclei in the non recurrent cases were in the diploid range, whereas in recurrent tumours there was a reduction in the number of diploid cells associated with an increase in 2c–4c and 4c components Recurrent tumours also showed a higher number of nucleolar organizer regions positively stained using an argyrophil method. The mitotic count and the nucleolar organizer regions appeared to be the best predictors for recurrence.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>2626384</pmid><doi>10.1016/S0344-0338(89)80231-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pathology, research and practice, 1989-11, Vol.185 (5), p.746-751 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged DNA content DNA, Neoplasm - analysis DNA, Neoplasm - genetics Female Humans Male Meningeal Neoplasms - genetics Meningeal Neoplasms - pathology Meningioma - genetics Meningioma - pathology Middle Aged Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Nucleolar organizer regions Nucleolus Organizer Region Ploidies Quantitative pathology Recurrent meningiomas |
| title | Quantitative Evaluation of Recurrent Meningiomas |
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