Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture

Neurons dissociated from the hippocampal formations of neonatal rats were grown in medium containing kynurenic acid (a glutamate receptor antagonist) and elevated Mg 2+. Such chronically blocked neurons, when first exposed to medium without blockers (after 0.5 – 5.0 months), generated intense seizur...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1989-08, Vol.3 (2), p.199-207
Hauptverfasser:	Furshpan, E.J., Potter, D.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - physiology Cells, Cultured Electric Conductivity - drug effects Electric Conductivity - physiology Hippocampus - cytology Hippocampus - physiopathology Hippocampus - ultrastructure Kynurenic Acid - pharmacology Magnesium - pharmacology Membrane Potentials - drug effects Membrane Potentials - physiology Neurons - cytology Neurons - physiology Neurons - ultrastructure Rats Receptors, Glutamate Receptors, Neurotransmitter - drug effects Seizures - physiopathology
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