Effects of d-amphetamine on human aggressive responding maintained by avoidance of provocation
Male subjects were administered placebo and three doses of d-amphetamine (5, 10 and 20 mg per 70 kg of body weight) under double-blind conditions in a laboratory setting which provided both aggressive and nonaggressive response options. The nonaggressive response was button pressing maintained by th...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1989-09, Vol.34 (1), p.65-71 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Cherek, Don R. Steinberg, Joel L. Kelly, Thomas H. Sebastian, C.Simon |
| description | Male subjects were administered placebo and three doses of d-amphetamine (5, 10 and 20 mg per 70 kg of body weight) under double-blind conditions in a laboratory setting which provided both aggressive and nonaggressive response options. The nonaggressive response was button pressing maintained by the presentation of points which were exchanged for money. The aggressive response was pressing another button which ostensibly resulted in the subtraction of points from a fictitious person. Aggressive responding was initiated by subtracting points from the subject. Point subtractions were attributed to the other person. Aggressive responding was maintained by an avoidance contingency between aggressive responses and scheduled provoking point subtraction presentations. d-Amphetamine increased nonaggressive responding, while aggressive responding was increased at the 10 mg dose and 20 mg resulted in significant decreases in aggressive responding relative to the 10 mg dose. Comparisons with previous research indicate that the contingency relationship between aggressive responses and presentation of provoking point subtractions can alter the effects of d-amphetamine on aggressive responding. |
| doi_str_mv | 10.1016/0091-3057(89)90354-7 |
| format | Article |
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The nonaggressive response was button pressing maintained by the presentation of points which were exchanged for money. The aggressive response was pressing another button which ostensibly resulted in the subtraction of points from a fictitious person. Aggressive responding was initiated by subtracting points from the subject. Point subtractions were attributed to the other person. Aggressive responding was maintained by an avoidance contingency between aggressive responses and scheduled provoking point subtraction presentations. d-Amphetamine increased nonaggressive responding, while aggressive responding was increased at the 10 mg dose and 20 mg resulted in significant decreases in aggressive responding relative to the 10 mg dose. Comparisons with previous research indicate that the contingency relationship between aggressive responses and presentation of provoking point subtractions can alter the effects of d-amphetamine on aggressive responding.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(89)90354-7</identifier><identifier>PMID: 2626455</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aggression - drug effects ; Aggressive ; Avoidance Learning - drug effects ; Biological and medical sciences ; d-Amphetamine ; Dextroamphetamine - pharmacology ; Dose-Response Relationship, Drug ; Double-Blind Method ; Human ; Humans ; Male ; Medical sciences ; Neuropharmacology ; Operant ; Pharmacology. 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The nonaggressive response was button pressing maintained by the presentation of points which were exchanged for money. The aggressive response was pressing another button which ostensibly resulted in the subtraction of points from a fictitious person. Aggressive responding was initiated by subtracting points from the subject. Point subtractions were attributed to the other person. Aggressive responding was maintained by an avoidance contingency between aggressive responses and scheduled provoking point subtraction presentations. d-Amphetamine increased nonaggressive responding, while aggressive responding was increased at the 10 mg dose and 20 mg resulted in significant decreases in aggressive responding relative to the 10 mg dose. Comparisons with previous research indicate that the contingency relationship between aggressive responses and presentation of provoking point subtractions can alter the effects of d-amphetamine on aggressive responding.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aggression - drug effects</subject><subject>Aggressive</subject><subject>Avoidance Learning - drug effects</subject><subject>Biological and medical sciences</subject><subject>d-Amphetamine</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Operant</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9rFDEUx4NY6tr6HyjkIGIPo5mZ_JhcBCm1LRR60WvDm-RlG9lJ1mR2of-9GXfZo4fwCO_zvi98Qsj7ln1pWSu_MqbbpmdCfR70lWa94I16RVbtoPpGtEq9JqsT8oa8LeU3Y4x3Up2T8052kguxIk833qOdC02eugam7TPOMIWINEX6vJsgUlivM5YS9khr3aboQlzTCUKc60FHxxcK-xQcRItLzjanfbIwhxQvyZmHTcF3x3pBfv24-Xl91zw83t5ff39obD_IueEcBgYeUPQIgIBW1QvzVgvoRuB8EINW4HU_cjGKjnOnUXuOUjk1IPYX5NMht-7-s8MymykUi5sNREy7YpTmSmnRVZAfQJtTKRm92eYwQX4xLTOLVrM4M4szM2jzT6tRdezDMX83TuhOQ0ePtf_x2IdiYeNzdRHKCZOyZ1Iu278dMKwu9gGzKTZg1eZCrr9gXAr_f8dftI-Vxg</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>Cherek, Don R.</creator><creator>Steinberg, Joel L.</creator><creator>Kelly, Thomas H.</creator><creator>Sebastian, C.Simon</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890901</creationdate><title>Effects of d-amphetamine on human aggressive responding maintained by avoidance of provocation</title><author>Cherek, Don R. ; Steinberg, Joel L. ; Kelly, Thomas H. ; Sebastian, C.Simon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-44a80afae53eaaeaec7fae0fc95a2ba4485897af93b45b5244d9e9f4e67d78ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aggression - drug effects</topic><topic>Aggressive</topic><topic>Avoidance Learning - drug effects</topic><topic>Biological and medical sciences</topic><topic>d-Amphetamine</topic><topic>Dextroamphetamine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Operant</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cherek, Don R.</creatorcontrib><creatorcontrib>Steinberg, Joel L.</creatorcontrib><creatorcontrib>Kelly, Thomas H.</creatorcontrib><creatorcontrib>Sebastian, C.Simon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cherek, Don R.</au><au>Steinberg, Joel L.</au><au>Kelly, Thomas H.</au><au>Sebastian, C.Simon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of d-amphetamine on human aggressive responding maintained by avoidance of provocation</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>34</volume><issue>1</issue><spage>65</spage><epage>71</epage><pages>65-71</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Male subjects were administered placebo and three doses of d-amphetamine (5, 10 and 20 mg per 70 kg of body weight) under double-blind conditions in a laboratory setting which provided both aggressive and nonaggressive response options. The nonaggressive response was button pressing maintained by the presentation of points which were exchanged for money. The aggressive response was pressing another button which ostensibly resulted in the subtraction of points from a fictitious person. Aggressive responding was initiated by subtracting points from the subject. Point subtractions were attributed to the other person. Aggressive responding was maintained by an avoidance contingency between aggressive responses and scheduled provoking point subtraction presentations. d-Amphetamine increased nonaggressive responding, while aggressive responding was increased at the 10 mg dose and 20 mg resulted in significant decreases in aggressive responding relative to the 10 mg dose. Comparisons with previous research indicate that the contingency relationship between aggressive responses and presentation of provoking point subtractions can alter the effects of d-amphetamine on aggressive responding.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2626455</pmid><doi>10.1016/0091-3057(89)90354-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1989-09, Vol.34 (1), p.65-71 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aggression - drug effects Aggressive Avoidance Learning - drug effects Biological and medical sciences d-Amphetamine Dextroamphetamine - pharmacology Dose-Response Relationship, Drug Double-Blind Method Human Humans Male Medical sciences Neuropharmacology Operant Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology |
| title | Effects of d-amphetamine on human aggressive responding maintained by avoidance of provocation |
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