Role of Left Inferior Prefrontal Cortex in Retrieval of Semantic Knowledge: A Reevaluation
A number of neuroimaging findings have been interpreted as evidence that the left inferior frontal gyrus (IFG) subserves retrieval of semantic knowledge. We provide a fundamentally different interpretation, that it is not retrieval of semantic knowledge per se that is associated with left IFG activi...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1997-12, Vol.94 (26), p.14792-14797 |
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| container_issue | 26 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Thompson-Schill, S L D'Esposito, M Aguirre, G K Farah, M J |
| description | A number of neuroimaging findings have been interpreted as evidence that the left inferior frontal gyrus (IFG) subserves retrieval of semantic knowledge. We provide a fundamentally different interpretation, that it is not retrieval of semantic knowledge per se that is associated with left IFG activity but rather selection of information among competing alternatives from semantic memory. Selection demands were varied across three semantic tasks in a single group of subjects. Functional magnetic resonance imaging signal in overlapping regions of left IFG was dependent on selection demands in all three tasks. In addition, the degree of semantic processing was varied independently of selection demands in one of the tasks. The absence of left IFG activity for this comparison counters the argument that the effects of selection can be attributed solely to variations in degree of semantic retrieval. Our findings suggest that it is selection, not retrieval, of semantic knowledge that drives activity in the left IFG. |
| doi_str_mv | 10.1073/pnas.94.26.14792 |
| format | Article |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Biological Sciences Brain Frequency ranges Humans Magnetic Resonance Imaging Memory Memory recall Neurology Neuropsychology Nouns Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiology Radiography Semantics Verbal Behavior Verbs Words Working memory |
| title | Role of Left Inferior Prefrontal Cortex in Retrieval of Semantic Knowledge: A Reevaluation |
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