Inhibition of 5-Lipoxygenase by Substituted 3,4-Dihydro-2H-1,4-thiazines

A series of substituted 3,4-dihydro-2H-1,4-thiazines inhibit 5-lipoxygenase from rat leukocytes and exhibit submicromolar IC50 values. A novel synthesis of these compounds was developed based on the formation of hydroxymethyleneamine 13 and its cyclization to the title compounds. The dihydrothiazine...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1989-11, Vol.78 (11), p.937-943
Hauptverfasser:	Weintraub, Philip M., Skoog, Mark T., Nichols, James S., Wiseman, Jeffrey S., Huber, Edward W., Baugh, Larry E., Farrell, Amy M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-dihydro-2H-1,4-thiazine 5-lipoxygenase Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chemical Phenomena Chemistry In Vitro Techniques Leukotriene B4 - metabolism Lipid Peroxides - pharmacology Lipoxygenase Inhibitors Medical sciences Neutrophils - drug effects Neutrophils - enzymology Pharmacology. Drug treatments Rats Thiazines - pharmacology
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