Ictal and interictal ECD-SPECT for focus localization in epilepsy
Forty‐one ECD (Technetium‐99m‐ethyl cysteinate dimer) SPECT investigations were undertaken in the course of a presurgical diagnostic work‐up in 23 patients with pharmacoresistant focal epilepsy. In 21 patients, both an ictal and interictal SPECT were conducted. In the patients receiving ictal SPECT...
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| Veröffentlicht in: | Acta neurologica Scandinavica 1997-11, Vol.96 (5), p.271-276 |
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| container_title | Acta neurologica Scandinavica |
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| creator | Runge, U. Kirsch, G. Petersen, B. Kallwellis, G. Gaab, M. R. Piek, J. Kessler, Ch |
| description | Forty‐one ECD (Technetium‐99m‐ethyl cysteinate dimer) SPECT investigations were undertaken in the course of a presurgical diagnostic work‐up in 23 patients with pharmacoresistant focal epilepsy. In 21 patients, both an ictal and interictal SPECT were conducted. In the patients receiving ictal SPECT the tracer was injected between 7 and 30 s after the seizure onset. Of the interictal SPECTs 17 of 23 showed focal hypoperfusion which was consistent in 17 cases (74%) with the area of the electrophysiological focus (EF) and 6 patients had a normal interictal SPECT. Of the ictal SPECTs 18 of 21 (86%) showed regional hyperperfusion, 18 of them in the same location as the EF. Ictal SPECT showed a hypoperfusion similar to that in interictal SPECT in another 3 patients. In these cases seizure duration was short (28–54 s), so that the tracer reached the brain postictally. Our results show that ictal ECD‐SPECT is an effective method for demonstrating an epileptogenic focus. Possible reasons for false‐negative ictal SPECT results are discussed. |
| doi_str_mv | 10.1111/j.1600-0404.1997.tb00283.x |
| format | Article |
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In these cases seizure duration was short (28–54 s), so that the tracer reached the brain postictally. Our results show that ictal ECD‐SPECT is an effective method for demonstrating an epileptogenic focus. Possible reasons for false‐negative ictal SPECT results are discussed.</description><identifier>ISSN: 0001-6314</identifier><identifier>EISSN: 1600-0404</identifier><identifier>DOI: 10.1111/j.1600-0404.1997.tb00283.x</identifier><identifier>PMID: 9404995</identifier><identifier>CODEN: ANRSAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Blood Flow Velocity - physiology ; Brain - blood supply ; Brain - diagnostic imaging ; Brain Mapping ; brain SPECT ; Cerebral Cortex - blood supply ; Cerebral Cortex - diagnostic imaging ; Child ; Cysteine - analogs & derivatives ; Electroencephalography ; Epilepsy - diagnostic imaging ; Epilepsy - etiology ; Epilepsy - physiopathology ; Female ; focal epilepsy ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. 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R.</creatorcontrib><creatorcontrib>Piek, J.</creatorcontrib><creatorcontrib>Kessler, Ch</creatorcontrib><title>Ictal and interictal ECD-SPECT for focus localization in epilepsy</title><title>Acta neurologica Scandinavica</title><addtitle>Acta Neurol Scand</addtitle><description>Forty‐one ECD (Technetium‐99m‐ethyl cysteinate dimer) SPECT investigations were undertaken in the course of a presurgical diagnostic work‐up in 23 patients with pharmacoresistant focal epilepsy. In 21 patients, both an ictal and interictal SPECT were conducted. In the patients receiving ictal SPECT the tracer was injected between 7 and 30 s after the seizure onset. Of the interictal SPECTs 17 of 23 showed focal hypoperfusion which was consistent in 17 cases (74%) with the area of the electrophysiological focus (EF) and 6 patients had a normal interictal SPECT. Of the ictal SPECTs 18 of 21 (86%) showed regional hyperperfusion, 18 of them in the same location as the EF. Ictal SPECT showed a hypoperfusion similar to that in interictal SPECT in another 3 patients. In these cases seizure duration was short (28–54 s), so that the tracer reached the brain postictally. Our results show that ictal ECD‐SPECT is an effective method for demonstrating an epileptogenic focus. Possible reasons for false‐negative ictal SPECT results are discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - physiology</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Mapping</subject><subject>brain SPECT</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Child</subject><subject>Cysteine - analogs & derivatives</subject><subject>Electroencephalography</subject><subject>Epilepsy - diagnostic imaging</subject><subject>Epilepsy - etiology</subject><subject>Epilepsy - physiopathology</subject><subject>Female</subject><subject>focal epilepsy</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Organotechnetium Compounds</subject><subject>Radiopharmaceuticals</subject><subject>Regional Blood Flow - physiology</subject><subject>Seizures - diagnostic imaging</subject><subject>Seizures - etiology</subject><subject>Seizures - physiopathology</subject><subject>Sensitivity and Specificity</subject><subject>technetium-99m-ECD</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0001-6314</issn><issn>1600-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1r2zAUhkXZSNOPn1AwY-zO7tGHLWsXg5BkaWloC23JpZBtCZQ5diY5NOmvr7yY3E8gxOF9z3uOHoS-YUhwOLfrBGcAMTBgCRaCJ10BQHKa7M_Q-CR9QWMAwHFGMTtHF96vQ0U4YyM0EkEXIh2jyX3ZqTpSTRXZptPO_ivn01n88jyfvkamdeGWOx_Vbalq-6E62zbBG-mtrfXWH67QV6Nqr6-H9xK9_Z6_Tu_i5dPifjpZxmUKBMcFMUJggykxFWie4pRUKc-wETQFqkWhBFY5o5UB4BoMhC9x0FlJcqEJK-gl-nHM3br27077Tm6sL3Vdq0a3Oy-5YJkgOQTjz6OxdK33Thu5dXaj3EFikD0_uZY9JNlDkj0_OfCT-9B8M0zZFRtdnVoHYEH_PujKBx7Gqaa0_mQjwFiO-x1-HW3vAdLhPxaQk8c54TgExMcA6zu9PwUo90dmnPJUrh4XEs8eyMvymcsV_QRNKplf</recordid><startdate>199711</startdate><enddate>199711</enddate><creator>Runge, U.</creator><creator>Kirsch, G.</creator><creator>Petersen, B.</creator><creator>Kallwellis, G.</creator><creator>Gaab, M. R.</creator><creator>Piek, J.</creator><creator>Kessler, Ch</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199711</creationdate><title>Ictal and interictal ECD-SPECT for focus localization in epilepsy</title><author>Runge, U. ; Kirsch, G. ; Petersen, B. ; Kallwellis, G. ; Gaab, M. R. ; Piek, J. ; Kessler, Ch</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5021-b2f991f132fd0e75152d5761f93503e9ba91a843df007e0f0b0070e6c289e24b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - physiology</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Mapping</topic><topic>brain SPECT</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Child</topic><topic>Cysteine - analogs & derivatives</topic><topic>Electroencephalography</topic><topic>Epilepsy - diagnostic imaging</topic><topic>Epilepsy - etiology</topic><topic>Epilepsy - physiopathology</topic><topic>Female</topic><topic>focal epilepsy</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monitoring, Physiologic</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Organotechnetium Compounds</topic><topic>Radiopharmaceuticals</topic><topic>Regional Blood Flow - physiology</topic><topic>Seizures - diagnostic imaging</topic><topic>Seizures - etiology</topic><topic>Seizures - physiopathology</topic><topic>Sensitivity and Specificity</topic><topic>technetium-99m-ECD</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Runge, U.</creatorcontrib><creatorcontrib>Kirsch, G.</creatorcontrib><creatorcontrib>Petersen, B.</creatorcontrib><creatorcontrib>Kallwellis, G.</creatorcontrib><creatorcontrib>Gaab, M. R.</creatorcontrib><creatorcontrib>Piek, J.</creatorcontrib><creatorcontrib>Kessler, Ch</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Runge, U.</au><au>Kirsch, G.</au><au>Petersen, B.</au><au>Kallwellis, G.</au><au>Gaab, M. R.</au><au>Piek, J.</au><au>Kessler, Ch</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ictal and interictal ECD-SPECT for focus localization in epilepsy</atitle><jtitle>Acta neurologica Scandinavica</jtitle><addtitle>Acta Neurol Scand</addtitle><date>1997-11</date><risdate>1997</risdate><volume>96</volume><issue>5</issue><spage>271</spage><epage>276</epage><pages>271-276</pages><issn>0001-6314</issn><eissn>1600-0404</eissn><coden>ANRSAS</coden><abstract>Forty‐one ECD (Technetium‐99m‐ethyl cysteinate dimer) SPECT investigations were undertaken in the course of a presurgical diagnostic work‐up in 23 patients with pharmacoresistant focal epilepsy. In 21 patients, both an ictal and interictal SPECT were conducted. In the patients receiving ictal SPECT the tracer was injected between 7 and 30 s after the seizure onset. Of the interictal SPECTs 17 of 23 showed focal hypoperfusion which was consistent in 17 cases (74%) with the area of the electrophysiological focus (EF) and 6 patients had a normal interictal SPECT. Of the ictal SPECTs 18 of 21 (86%) showed regional hyperperfusion, 18 of them in the same location as the EF. Ictal SPECT showed a hypoperfusion similar to that in interictal SPECT in another 3 patients. In these cases seizure duration was short (28–54 s), so that the tracer reached the brain postictally. Our results show that ictal ECD‐SPECT is an effective method for demonstrating an epileptogenic focus. Possible reasons for false‐negative ictal SPECT results are discussed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9404995</pmid><doi>10.1111/j.1600-0404.1997.tb00283.x</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Biological and medical sciences Blood Flow Velocity - physiology Brain - blood supply Brain - diagnostic imaging Brain Mapping brain SPECT Cerebral Cortex - blood supply Cerebral Cortex - diagnostic imaging Child Cysteine - analogs & derivatives Electroencephalography Epilepsy - diagnostic imaging Epilepsy - etiology Epilepsy - physiopathology Female focal epilepsy Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged Monitoring, Physiologic Nervous system (semeiology, syndromes) Neurology Organotechnetium Compounds Radiopharmaceuticals Regional Blood Flow - physiology Seizures - diagnostic imaging Seizures - etiology Seizures - physiopathology Sensitivity and Specificity technetium-99m-ECD Tomography, Emission-Computed, Single-Photon |
| title | Ictal and interictal ECD-SPECT for focus localization in epilepsy |
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