Increased synthesis and mRNA of surfactant protein A in oxygen-exposed rats

Surfactant protein A (SP-A) is an abundant glycoprotein in surfactant that is synthesized and secreted by alveolar type II cells and likely has important roles in mediating surfactant function and metabolism. In the present study, we demonstrate that exposure to 85% oxygen increased alveolar lavage...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 1989-08, Vol.1 (2), p.119-125
Hauptverfasser:	Nogee, L M, Wispé, J R, Clark, J C, Whitsett, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Bronchoalveolar Lavage Fluid - metabolism Cells, Cultured Electrophoresis, Gel, Two-Dimensional Lung - cytology Lung - metabolism Lung - secretion Male Nucleic Acid Hybridization Oxygen - pharmacology Precipitin Tests Proteolipids - biosynthesis Proteolipids - genetics Proteolipids - secretion Pulmonary Alveoli - cytology Pulmonary Alveoli - metabolism Pulmonary Surfactant-Associated Protein A Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants - biosynthesis Pulmonary Surfactants - genetics Pulmonary Surfactants - secretion Rats Rats, Inbred Strains RNA, Messenger - biosynthesis
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