The Lipoic Acid Analogue 1,2-Diselenolane-3-pentanoic Acid Protects Human Low Density Lipoprotein against Oxidative Modification Mediated by Copper Ion

1,2-Diselenolane-3-pentanoic acid, in which the sulfur atoms of α-lipoic acid are replaced with selenium, displayed markedly different antioxidant properties when compared to α-lipoic acid. 1,2-Diselenolane-3-pentanoic acid was unable to inhibit protein oxidative modification of human low density li...

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Veröffentlicht in:	Biochemical and biophysical research communications 1997-11, Vol.240 (3), p.819-824
Hauptverfasser:	Matsugo, Seiichi, Yan, Liang-Jun, Konishi, Tetsuya, Youn, Hong-Duk, Lodge, John K., Ulrich, Heinz, Packer, Lester
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - chemistry Antioxidants - pharmacology Apolipoproteins B - metabolism Copper - metabolism Free Radical Scavengers - pharmacology Humans Lipid Peroxidation - drug effects LIPOPROTEINAS LIPOPROTEINE LIPOPROTEINS Lipoproteins, LDL - metabolism Molecular Structure Naphthalenes - pharmacology Organoselenium Compounds - chemistry Organoselenium Compounds - pharmacology Oxidation-Reduction Pentanoic Acids - chemistry Pentanoic Acids - pharmacology Salicylates - metabolism Salicylic Acid Serum Albumin - metabolism Thiobarbituric Acid Reactive Substances - analysis
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