Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure

Benzodiazepine ligands of differing efficacy including the agonist, diazepam, the partial agonist, Ro 16–6028 and the antagonist, Ro 15–1788, were administered in vivo to rats continuously for 3 weeks. The magnitude of change in various measures of GABA sensitivity could be correlated directly with...

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Veröffentlicht in:	European journal of pharmacology 1989-11, Vol.170 (3), p.145-155
Hauptverfasser:	Hernandez, Theresa D., Heninger, Catherine, Wilson, Marlene A., Gallager, Dorothy W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist efficacy Animals Anticonvulsants Anticonvulsants. Antiepileptics. Antiparkinson agents Behavior, Animal - drug effects Benzodiazepines (chronic) Benzodiazepines - pharmacology Benzodiazepinones - pharmacology Bicuculline - metabolism Bicuculline - pharmacology Biological and medical sciences Brain Chemistry - drug effects Diazepam - pharmacology Drug Tolerance Electrophysiology Flumazenil - pharmacology GABA gamma-Aminobutyric Acid - physiology Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Raphe Nuclei - drug effects Raphe Nuclei - physiology Rats Rats, Inbred Strains Seizures - physiopathology Tolerance
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