Effect of Salmonella typhimurium porins on biological activities of human polymorphonuclear leukocytes
The effect of Salmonella typhimurium porins on human polymorphonuclear leukocytes (PMNs) was studied. Labeled porins were shown to bind to the PMNs, and could be completely displaced by unlabeled porins. The binding caused modifications of membrane integrity and of the physico-chemical characteristi...
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| Veröffentlicht in: | Microbial pathogenesis 1989-11, Vol.7 (5), p.337-346 |
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| container_title | Microbial pathogenesis |
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| creator | Tufano, Maria Antonietta lanniello, Raffaele Galdiero, Marilena De Martino, Luisa Galdiero, Francesco |
| description | The effect of
Salmonella typhimurium porins on human polymorphonuclear leukocytes (PMNs) was studied. Labeled porins were shown to bind to the PMNs, and could be completely displaced by unlabeled porins. The binding caused modifications of membrane integrity and of the physico-chemical characteristics of the PMN surface, e.g. decreased oxidative burst, decreased hydrophobicity and altered cell morphology. The porins acted as both chemotaxins and chemotaxinogens. When PMNs were preincubated with porins their migration in the presence of commonly used chemoattractants (serum activated by zymosan or N-formyl-
l-methionyl-
l-leucyl-
l-phenylalanine) was inhibited. |
| doi_str_mv | 10.1016/0882-4010(89)90037-5 |
| format | Article |
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Salmonella typhimurium porins on human polymorphonuclear leukocytes (PMNs) was studied. Labeled porins were shown to bind to the PMNs, and could be completely displaced by unlabeled porins. The binding caused modifications of membrane integrity and of the physico-chemical characteristics of the PMN surface, e.g. decreased oxidative burst, decreased hydrophobicity and altered cell morphology. The porins acted as both chemotaxins and chemotaxinogens. When PMNs were preincubated with porins their migration in the presence of commonly used chemoattractants (serum activated by zymosan or N-formyl-
l-methionyl-
l-leucyl-
l-phenylalanine) was inhibited.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/0882-4010(89)90037-5</identifier><identifier>PMID: 2560111</identifier><identifier>CODEN: MIPAEV</identifier><language>eng</language><publisher>Oxford: Elsevier India Pvt Ltd</publisher><subject>Bacterial Outer Membrane Proteins - metabolism ; Bacterial Outer Membrane Proteins - pharmacology ; Biological and medical sciences ; Cell Membrane - ultrastructure ; Cells, Cultured ; Chemotaxis, Leukocyte ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Kinetics ; Macrophage-1 Antigen ; Myeloid cells: ontogeny, maturation, markers, receptors ; Neutrophils - drug effects ; Neutrophils - metabolism ; Neutrophils - ultrastructure ; PMNs ; Porins ; Receptors, Complement - metabolism ; Receptors, Fc - metabolism ; Salmonella typhimurium ; Salmonella typhimurium - metabolism</subject><ispartof>Microbial pathogenesis, 1989-11, Vol.7 (5), p.337-346</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-1320b1eb4b6312269689eb3095bba137c37751106a883d53612f82d088bf9e4b3</citedby><cites>FETCH-LOGICAL-c417t-1320b1eb4b6312269689eb3095bba137c37751106a883d53612f82d088bf9e4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0882-4010(89)90037-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6725508$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2560111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tufano, Maria Antonietta</creatorcontrib><creatorcontrib>lanniello, Raffaele</creatorcontrib><creatorcontrib>Galdiero, Marilena</creatorcontrib><creatorcontrib>De Martino, Luisa</creatorcontrib><creatorcontrib>Galdiero, Francesco</creatorcontrib><title>Effect of Salmonella typhimurium porins on biological activities of human polymorphonuclear leukocytes</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>The effect of
Salmonella typhimurium porins on human polymorphonuclear leukocytes (PMNs) was studied. Labeled porins were shown to bind to the PMNs, and could be completely displaced by unlabeled porins. The binding caused modifications of membrane integrity and of the physico-chemical characteristics of the PMN surface, e.g. decreased oxidative burst, decreased hydrophobicity and altered cell morphology. The porins acted as both chemotaxins and chemotaxinogens. When PMNs were preincubated with porins their migration in the presence of commonly used chemoattractants (serum activated by zymosan or N-formyl-
l-methionyl-
l-leucyl-
l-phenylalanine) was inhibited.</description><subject>Bacterial Outer Membrane Proteins - metabolism</subject><subject>Bacterial Outer Membrane Proteins - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane - ultrastructure</subject><subject>Cells, Cultured</subject><subject>Chemotaxis, Leukocyte</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Kinetics</subject><subject>Macrophage-1 Antigen</subject><subject>Myeloid cells: ontogeny, maturation, markers, receptors</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Neutrophils - ultrastructure</subject><subject>PMNs</subject><subject>Porins</subject><subject>Receptors, Complement - metabolism</subject><subject>Receptors, Fc - metabolism</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - metabolism</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EKtvCG4CUA0JwCMzYsWNfKqGqBaRKHICzZTsOa3DiYCeV9u1J2NUe4eTDfP_I8_2EvEB4h4DiPUhJ6wYQ3kj1VgGwtuaPyA5BiRopyMdkd0aekstSfgKAapi6IBeUC0DEHelv-967uUp99dXEIY0-RlPNh2kfhiWHZaimlMNYqjRWNqSYfgRnYmXcHB7CHHzZkvtlMOMKxsOQ8rRP4-KiN7mKfvmV3GH25Rl50ptY_PPTe0W-391-u_lU33_5-Pnmw33tGmznGhkFi942VjCkVCghlbcMFLfWIGsda1uOCMJIyTrOBNJe0m490_bKN5ZdkdfHvVNOvxdfZj2E4rabRp-WolvVCAaN-i-IvKHQtriCzRF0OZWSfa-nHAaTDxpBbz3oTbLeJGup9N8eNF9jL0_7Fzv47hw6iV_nr05zU1ahfTajC-WMiZZyDnLFro-YX6U9BJ91ccGPznchr7XpLoV__-MPqCykRw</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Tufano, Maria Antonietta</creator><creator>lanniello, Raffaele</creator><creator>Galdiero, Marilena</creator><creator>De Martino, Luisa</creator><creator>Galdiero, Francesco</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19891101</creationdate><title>Effect of Salmonella typhimurium porins on biological activities of human polymorphonuclear leukocytes</title><author>Tufano, Maria Antonietta ; lanniello, Raffaele ; Galdiero, Marilena ; De Martino, Luisa ; Galdiero, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1320b1eb4b6312269689eb3095bba137c37751106a883d53612f82d088bf9e4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Bacterial Outer Membrane Proteins - metabolism</topic><topic>Bacterial Outer Membrane Proteins - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane - ultrastructure</topic><topic>Cells, Cultured</topic><topic>Chemotaxis, Leukocyte</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Kinetics</topic><topic>Macrophage-1 Antigen</topic><topic>Myeloid cells: ontogeny, maturation, markers, receptors</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>Neutrophils - ultrastructure</topic><topic>PMNs</topic><topic>Porins</topic><topic>Receptors, Complement - metabolism</topic><topic>Receptors, Fc - metabolism</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tufano, Maria Antonietta</creatorcontrib><creatorcontrib>lanniello, Raffaele</creatorcontrib><creatorcontrib>Galdiero, Marilena</creatorcontrib><creatorcontrib>De Martino, Luisa</creatorcontrib><creatorcontrib>Galdiero, Francesco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tufano, Maria Antonietta</au><au>lanniello, Raffaele</au><au>Galdiero, Marilena</au><au>De Martino, Luisa</au><au>Galdiero, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Salmonella typhimurium porins on biological activities of human polymorphonuclear leukocytes</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>7</volume><issue>5</issue><spage>337</spage><epage>346</epage><pages>337-346</pages><issn>0882-4010</issn><eissn>1096-1208</eissn><coden>MIPAEV</coden><abstract>The effect of
Salmonella typhimurium porins on human polymorphonuclear leukocytes (PMNs) was studied. Labeled porins were shown to bind to the PMNs, and could be completely displaced by unlabeled porins. The binding caused modifications of membrane integrity and of the physico-chemical characteristics of the PMN surface, e.g. decreased oxidative burst, decreased hydrophobicity and altered cell morphology. The porins acted as both chemotaxins and chemotaxinogens. When PMNs were preincubated with porins their migration in the presence of commonly used chemoattractants (serum activated by zymosan or N-formyl-
l-methionyl-
l-leucyl-
l-phenylalanine) was inhibited.</abstract><cop>Oxford</cop><pub>Elsevier India Pvt Ltd</pub><pmid>2560111</pmid><doi>10.1016/0882-4010(89)90037-5</doi><tpages>10</tpages></addata></record> |
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| ispartof | Microbial pathogenesis, 1989-11, Vol.7 (5), p.337-346 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Bacterial Outer Membrane Proteins - metabolism Bacterial Outer Membrane Proteins - pharmacology Biological and medical sciences Cell Membrane - ultrastructure Cells, Cultured Chemotaxis, Leukocyte Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Kinetics Macrophage-1 Antigen Myeloid cells: ontogeny, maturation, markers, receptors Neutrophils - drug effects Neutrophils - metabolism Neutrophils - ultrastructure PMNs Porins Receptors, Complement - metabolism Receptors, Fc - metabolism Salmonella typhimurium Salmonella typhimurium - metabolism |
| title | Effect of Salmonella typhimurium porins on biological activities of human polymorphonuclear leukocytes |
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