Progressive Cyclic Nucleotide-induced Conformational Changes in the cGMP-dependent Protein Kinase Studied by Small Angle X-ray Scattering in Solution

Small angle scattering data from bovine lung type Iα cGMP-dependent protein kinase (PKG) in the absence of cGMP show the protein to have a highly asymmetric structure with a radius of gyration (Rg ) of 45 Å and a maximum linear dimension (dmax) of 165 Å. The addition of cGMP induces a marked conform...

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Veröffentlicht in:	The Journal of biological chemistry 1997-12, Vol.272 (50), p.31929-31936
Hauptverfasser:	Zhao, Jinkui, Trewhella, Jill, Corbin, Jackie, Francis, Sharron, Mitchell, Ryan, Brushia, Robert, Walsh, Donal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BINDING BOVIN C-GMP CATTLE Circular Dichroism Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - chemistry Cyclic GMP-Dependent Protein Kinases - metabolism ESPECTROMETRIA GANADO BOVINO LUNGS MOLECULAR CONFORMATION NUCLEOTIDE NUCLEOTIDES NUCLEOTIDOS POUMON Protein Conformation PROTEIN KINASE PROTEINA QUINASA PROTEINE KINASE PULMONES Scattering, Radiation SPECTRAL DATA SPECTROMETRIE SPECTROMETRY Spectroscopy, Fourier Transform Infrared X-Ray Diffraction
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