Implications of obesity for target organ injuries and cardiovascular risk factors in hypertensive subjects
The effects of obesity on target organ injuries and cardiovascular risk factors were examined in hypertensive subjects. The subjects were 22 obese (OB-HT) and 54 nonobese (NO-HT) men with never treated essential hypertension, and 37 obese (OB-NT) and 50 nonobese (NO-NT) normotensive men. In these 4...
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| Veröffentlicht in: | Nihon Jinzo Gakkai shi 1997, Vol.39(7), pp.746-752 |
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| container_title | Nihon Jinzo Gakkai shi |
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| creator | NAKAMURA, Miki ISHIMITSU, Toshihiko MATSUOKA, Hiroaki OHRUI, Masami HISAUCHI, Tohru |
| description | The effects of obesity on target organ injuries and cardiovascular risk factors were examined in hypertensive subjects. The subjects were 22 obese (OB-HT) and 54 nonobese (NO-HT) men with never treated essential hypertension, and 37 obese (OB-NT) and 50 nonobese (NO-NT) normotensive men. In these 4 groups with the average age of about 50 years, we evaluated serum lipids, glucose tolerance, and hypertensive organ injuries in the heart, kidney, and optic fundus. Although the fasting blood glucose levels were similar in the 4 groups, the area under the blood glucose curve after 75g glucose ingestion (NO NT 15.6, OB-NT 17.5, NO HT 15.8, OB-HT l7.6 × 103 mg/dl ⋅ min ; p |
| doi_str_mv | 10.14842/jpnjnephrol1959.39.746 |
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The subjects were 22 obese (OB-HT) and 54 nonobese (NO-HT) men with never treated essential hypertension, and 37 obese (OB-NT) and 50 nonobese (NO-NT) normotensive men. In these 4 groups with the average age of about 50 years, we evaluated serum lipids, glucose tolerance, and hypertensive organ injuries in the heart, kidney, and optic fundus. Although the fasting blood glucose levels were similar in the 4 groups, the area under the blood glucose curve after 75g glucose ingestion (NO NT 15.6, OB-NT 17.5, NO HT 15.8, OB-HT l7.6 × 103 mg/dl ⋅ min ; p<0.02) and the fast serum insulin level (NO-NT 7.3, OB-NT 10.1, NO HT 7.7, OB-HT 12.2 mU/l ; p<0.001) were increased in obese men. In OB-HT, serum HDL-cholesterol was decreased (- 11%, p <0.05) and triglycerides were increased (+58%, p <0.01) comparing with NO-NT. The incidence of electrocardiographic left ventricular hypertrophy was not significantly different among the 4 groups, however, urinary albumin excretion was increased in OB-HT (NO NT 3.0, OB-NT 3.4, NO-HT 3.6, OB-HT 4.3 mg/g creatinine ; p<0.05) and sclerotic lesions of the retinal arteries were observed even in normotensive OB-NT. These data suggest that obesity unfavorably alters lipid and glucose metabolism, and acilitates organ injuries such as arteriosclerosis and renal dysfunction in hypertensive subjects.</description><identifier>ISSN: 0385-2385</identifier><identifier>EISSN: 1884-0728</identifier><identifier>DOI: 10.14842/jpnjnephrol1959.39.746</identifier><identifier>PMID: 9396243</identifier><language>jpn</language><publisher>Japan: Japanese Society of Nephrology</publisher><subject>Albuminuria - urine ; Cholesterol - blood ; Cholesterol, HDL - blood ; Humans ; Hypertension - physiopathology ; Kidney - pathology ; Male ; Middle Aged ; Myocardium - pathology ; Obesity - physiopathology ; obesity, hypertension, microalbuminuria, optic fundus, serum lipids ; Retina - pathology ; Risk Factors</subject><ispartof>The Japanese Journal of Nephrology, 1997, Vol.39(7), pp.746-752</ispartof><rights>Japanese Society of Nephrology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9396243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAKAMURA, Miki</creatorcontrib><creatorcontrib>ISHIMITSU, Toshihiko</creatorcontrib><creatorcontrib>MATSUOKA, Hiroaki</creatorcontrib><creatorcontrib>OHRUI, Masami</creatorcontrib><creatorcontrib>HISAUCHI, Tohru</creatorcontrib><title>Implications of obesity for target organ injuries and cardiovascular risk factors in hypertensive subjects</title><title>Nihon Jinzo Gakkai shi</title><addtitle>Jpn J Nephrol</addtitle><description>The effects of obesity on target organ injuries and cardiovascular risk factors were examined in hypertensive subjects. The subjects were 22 obese (OB-HT) and 54 nonobese (NO-HT) men with never treated essential hypertension, and 37 obese (OB-NT) and 50 nonobese (NO-NT) normotensive men. In these 4 groups with the average age of about 50 years, we evaluated serum lipids, glucose tolerance, and hypertensive organ injuries in the heart, kidney, and optic fundus. Although the fasting blood glucose levels were similar in the 4 groups, the area under the blood glucose curve after 75g glucose ingestion (NO NT 15.6, OB-NT 17.5, NO HT 15.8, OB-HT l7.6 × 103 mg/dl ⋅ min ; p<0.02) and the fast serum insulin level (NO-NT 7.3, OB-NT 10.1, NO HT 7.7, OB-HT 12.2 mU/l ; p<0.001) were increased in obese men. In OB-HT, serum HDL-cholesterol was decreased (- 11%, p <0.05) and triglycerides were increased (+58%, p <0.01) comparing with NO-NT. The incidence of electrocardiographic left ventricular hypertrophy was not significantly different among the 4 groups, however, urinary albumin excretion was increased in OB-HT (NO NT 3.0, OB-NT 3.4, NO-HT 3.6, OB-HT 4.3 mg/g creatinine ; p<0.05) and sclerotic lesions of the retinal arteries were observed even in normotensive OB-NT. These data suggest that obesity unfavorably alters lipid and glucose metabolism, and acilitates organ injuries such as arteriosclerosis and renal dysfunction in hypertensive subjects.</description><subject>Albuminuria - urine</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardium - pathology</subject><subject>Obesity - physiopathology</subject><subject>obesity, hypertension, microalbuminuria, optic fundus, serum lipids</subject><subject>Retina - pathology</subject><subject>Risk Factors</subject><issn>0385-2385</issn><issn>1884-0728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1P3DAURa0KREfAT6jqFbsMcfwVLysELSoSG1hHz87LjNOMndoO0vz7RpoRi27uW5yju3iXkO-s3jLRiuZ-nMMYcN6nODEjzZabrRbqC9mwthVVrZv2gmxq3sqqWeMruc3Z25q1uuZSiytyZbhRjeAbMj4f5sk7KD6GTONAo8Xsy5EOMdECaYeFxrSDQH0Yl-QxUwg9dZB6Hz8gu2WCRJPPf-gArsSUV5HujzOmgiH7D6R5sSO6km_I5QBTxtvzvSbvT49vD7-ql9efzw8_XqqxEapUWrOmQcbbWmo7KOydqIUbmLDaSsUYqMYMUiADawbVgzC1lEpxRGaVEJJfk7tT75zi3wVz6Q4-O5wmCBiX3GkjpOHcrOK3s7jYA_bdnPwB0rE7P2flv098zAV2-MkhFe8m7P5boeOm06dYx_i03B5Sh4H_A-qXiFY</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>NAKAMURA, Miki</creator><creator>ISHIMITSU, Toshihiko</creator><creator>MATSUOKA, Hiroaki</creator><creator>OHRUI, Masami</creator><creator>HISAUCHI, Tohru</creator><general>Japanese Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Implications of obesity for target organ injuries and cardiovascular risk factors in hypertensive subjects</title><author>NAKAMURA, Miki ; ISHIMITSU, Toshihiko ; MATSUOKA, Hiroaki ; OHRUI, Masami ; HISAUCHI, Tohru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j246t-77122e138057bf6edc404cf14b7b5611a629f54e1ab9f6da49055663ee1b64453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1997</creationdate><topic>Albuminuria - urine</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Kidney - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardium - pathology</topic><topic>Obesity - physiopathology</topic><topic>obesity, hypertension, microalbuminuria, optic fundus, serum lipids</topic><topic>Retina - pathology</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>NAKAMURA, Miki</creatorcontrib><creatorcontrib>ISHIMITSU, Toshihiko</creatorcontrib><creatorcontrib>MATSUOKA, Hiroaki</creatorcontrib><creatorcontrib>OHRUI, Masami</creatorcontrib><creatorcontrib>HISAUCHI, Tohru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nihon Jinzo Gakkai shi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAKAMURA, Miki</au><au>ISHIMITSU, Toshihiko</au><au>MATSUOKA, Hiroaki</au><au>OHRUI, Masami</au><au>HISAUCHI, Tohru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implications of obesity for target organ injuries and cardiovascular risk factors in hypertensive subjects</atitle><jtitle>Nihon Jinzo Gakkai shi</jtitle><addtitle>Jpn J Nephrol</addtitle><date>1997</date><risdate>1997</risdate><volume>39</volume><issue>7</issue><spage>746</spage><epage>752</epage><pages>746-752</pages><issn>0385-2385</issn><eissn>1884-0728</eissn><abstract>The effects of obesity on target organ injuries and cardiovascular risk factors were examined in hypertensive subjects. The subjects were 22 obese (OB-HT) and 54 nonobese (NO-HT) men with never treated essential hypertension, and 37 obese (OB-NT) and 50 nonobese (NO-NT) normotensive men. In these 4 groups with the average age of about 50 years, we evaluated serum lipids, glucose tolerance, and hypertensive organ injuries in the heart, kidney, and optic fundus. Although the fasting blood glucose levels were similar in the 4 groups, the area under the blood glucose curve after 75g glucose ingestion (NO NT 15.6, OB-NT 17.5, NO HT 15.8, OB-HT l7.6 × 103 mg/dl ⋅ min ; p<0.02) and the fast serum insulin level (NO-NT 7.3, OB-NT 10.1, NO HT 7.7, OB-HT 12.2 mU/l ; p<0.001) were increased in obese men. In OB-HT, serum HDL-cholesterol was decreased (- 11%, p <0.05) and triglycerides were increased (+58%, p <0.01) comparing with NO-NT. The incidence of electrocardiographic left ventricular hypertrophy was not significantly different among the 4 groups, however, urinary albumin excretion was increased in OB-HT (NO NT 3.0, OB-NT 3.4, NO-HT 3.6, OB-HT 4.3 mg/g creatinine ; p<0.05) and sclerotic lesions of the retinal arteries were observed even in normotensive OB-NT. These data suggest that obesity unfavorably alters lipid and glucose metabolism, and acilitates organ injuries such as arteriosclerosis and renal dysfunction in hypertensive subjects.</abstract><cop>Japan</cop><pub>Japanese Society of Nephrology</pub><pmid>9396243</pmid><doi>10.14842/jpnjnephrol1959.39.746</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Japanese Journal of Nephrology, 1997, Vol.39(7), pp.746-752 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Albuminuria - urine Cholesterol - blood Cholesterol, HDL - blood Humans Hypertension - physiopathology Kidney - pathology Male Middle Aged Myocardium - pathology Obesity - physiopathology obesity, hypertension, microalbuminuria, optic fundus, serum lipids Retina - pathology Risk Factors |
| title | Implications of obesity for target organ injuries and cardiovascular risk factors in hypertensive subjects |
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