DNA topoisomerase targeting drugs: mechanisms of action and perspectives

The nuclear enzymes DNA topoisomerases I and II appeared as cellular targets for several antitumor drugscampthotecin derivatives interacting with topoisomerase I, and actinomycin D, anthracycline derivatives, elliptinium acetate, mitoxantrone, epipodophyllotoxine derivatives, amsacrine and a new oli...

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Veröffentlicht in:	Anti-cancer drugs 1997-10, Vol.8 (9), p.811-822
Hauptverfasser:	Malonne, Hugues, Atassi, Ghanem
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Enzyme Inhibitors - pharmacology Humans Topoisomerase I Inhibitors Topoisomerase II Inhibitors
Online-Zugang:	Volltext
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