Negative Regulation of a Heterologous Promoter by Human Cytomegalovirus Immediate-Early Protein IE2

The HCMV IE2 protein promiscuously activates transcription of many viral and cellular genes. IE2 also negatively autoregulates its own expression by binding to a strategically positioned IE2 binding site, called CRS, located immediately downstream of the TATA box of the HCMV major IE promoter. Here...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1997-11, Vol.238 (2), p.372-379
Hauptverfasser:	Tsai, Hsiu-Lan, Kou, Guang-Hsiung, Tang, Fen-Mei, Wu, Cheng-Wen, Lin, Young-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cytomegalovirus - genetics Cytomegalovirus - physiology DNA - metabolism Gene Expression Regulation, Viral HeLa Cells Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - physiology Membrane Glycoproteins Promoter Regions, Genetic Recombinant Fusion Proteins - genetics Repetitive Sequences, Nucleic Acid Repressor Proteins - genetics Repressor Proteins - physiology Respiratory Syncytial Virus, Human - genetics TATA Box Trans-Activators - genetics Trans-Activators - physiology Transcription, Genetic Viral Envelope Proteins Viral Proteins
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