Decreases in Systemic Arterial and Hindquarters Perfusion Pressure in Response to Nociceptin Are Not Inhibited by Naloxone in the Rat
Czapla, M. A., H. C. Champion and P. J. Kadowitz. Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat. Peptides 18(8) 1197–1200, 1997.—Nociceptin, the endogenous ligand for the ORL 1 receptor, has been shown to decreas...
Gespeichert in:
| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1997, Vol.18 (8), p.1197-1200 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1200 |
|---|---|
| container_issue | 8 |
| container_start_page | 1197 |
| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 18 |
| creator | Czapla, M.A Champion, H.C Kadowitz, P.J |
| description | Czapla, M. A., H. C. Champion and P. J. Kadowitz.
Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat.
Peptides 18(8) 1197–1200, 1997.—Nociceptin, the endogenous ligand for the ORL
1 receptor, has been shown to decrease systemic arterial and hindquarters perfusion pressures in the rat. The present study was undertaken to determine if decreases in systemic arterial and hindquarters perfusion pressures, in response to nociceptin, are mediated by a naloxone-sensitive mechanism. Injections of nociceptin decreased systemic arterial and hindquarters perfusion pressures in a dose-related manner. The decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin were not altered by the administration of naloxone in a dose of 2 mg/kg IV. Met-enkephalin decreased systemic arterial and hindquarters perfusion pressures and responses to the opioid receptor agonist were significantly reduced by naloxone, whereas decreases in systemic arterial pressure in response to the nitric oxide donor, DEA/NO, were not altered. The results of the present study show that decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not mediated by a naloxone-sensitive mechanism in the rat. |
| doi_str_mv | 10.1016/S0196-9781(97)00178-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79458246</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196978197001782</els_id><sourcerecordid>79458246</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-d990282ccc67530c917cc2e1c37d0c76ccbaea2788312d04d22edde51d281863</originalsourceid><addsrcrecordid>eNqFkN1uEzEQhS0EKqHwCJV8heBiwfbu-ucKReWnlapQtb23nPFENdrYqe1F5AF4b3aTqLfczEhzzpnRfIRccPaJMy4_3zNuZGOU5h-M-sgYV7oRL8iCa9U2PZfmJVk8W16TN6X8Yox1ndFn5My0RjLJF-TvV4SMrmChIdL7fam4DUCXuWIObqAuenoVon8a3Twq9BbzZiwhRXqbsZQx4xy8w7JLsSCtia4SBMBdncbLSV2lSq_jY1iHip6u93TlhvQnxUOuPiK9c_UtebVxQ8F3p35OHr5_e7i8am5-_ri-XN400EpWG28ME1oAgFR9y8BwBSCQQ6s8AyUB1g6dUFq3XHjWeSHQe-y5F5pr2Z6T98e1u5yeRizVbkMBHAYXMY3FKtP1WnSzsT8aIadSMm7sLoety3vLmZ3p2wN9O6Odij3Qt2LKXZwOjOst-ufUCfekfznqOD35O2C2BQJGQB8yQrU-hf9c-AcR0JYk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79458246</pqid></control><display><type>article</type><title>Decreases in Systemic Arterial and Hindquarters Perfusion Pressure in Response to Nociceptin Are Not Inhibited by Naloxone in the Rat</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Czapla, M.A ; Champion, H.C ; Kadowitz, P.J</creator><creatorcontrib>Czapla, M.A ; Champion, H.C ; Kadowitz, P.J</creatorcontrib><description>Czapla, M. A., H. C. Champion and P. J. Kadowitz.
Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat.
Peptides 18(8) 1197–1200, 1997.—Nociceptin, the endogenous ligand for the ORL
1 receptor, has been shown to decrease systemic arterial and hindquarters perfusion pressures in the rat. The present study was undertaken to determine if decreases in systemic arterial and hindquarters perfusion pressures, in response to nociceptin, are mediated by a naloxone-sensitive mechanism. Injections of nociceptin decreased systemic arterial and hindquarters perfusion pressures in a dose-related manner. The decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin were not altered by the administration of naloxone in a dose of 2 mg/kg IV. Met-enkephalin decreased systemic arterial and hindquarters perfusion pressures and responses to the opioid receptor agonist were significantly reduced by naloxone, whereas decreases in systemic arterial pressure in response to the nitric oxide donor, DEA/NO, were not altered. The results of the present study show that decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not mediated by a naloxone-sensitive mechanism in the rat.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/S0196-9781(97)00178-2</identifier><identifier>PMID: 9396061</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Blood Pressure - drug effects ; Female ; Hindlimb - blood supply ; Hindquarters vascular bed ; Hypotensive response ; Male ; Naloxone ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; Nociceptin ; Nociceptin (orphanin FQ) ; Opioid Peptides - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid - agonists ; Regional Blood Flow - drug effects ; Systemic vascular bed</subject><ispartof>Peptides (New York, N.Y. : 1980), 1997, Vol.18 (8), p.1197-1200</ispartof><rights>1997 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-d990282ccc67530c917cc2e1c37d0c76ccbaea2788312d04d22edde51d281863</citedby><cites>FETCH-LOGICAL-c360t-d990282ccc67530c917cc2e1c37d0c76ccbaea2788312d04d22edde51d281863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196978197001782$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9396061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Czapla, M.A</creatorcontrib><creatorcontrib>Champion, H.C</creatorcontrib><creatorcontrib>Kadowitz, P.J</creatorcontrib><title>Decreases in Systemic Arterial and Hindquarters Perfusion Pressure in Response to Nociceptin Are Not Inhibited by Naloxone in the Rat</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Czapla, M. A., H. C. Champion and P. J. Kadowitz.
Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat.
Peptides 18(8) 1197–1200, 1997.—Nociceptin, the endogenous ligand for the ORL
1 receptor, has been shown to decrease systemic arterial and hindquarters perfusion pressures in the rat. The present study was undertaken to determine if decreases in systemic arterial and hindquarters perfusion pressures, in response to nociceptin, are mediated by a naloxone-sensitive mechanism. Injections of nociceptin decreased systemic arterial and hindquarters perfusion pressures in a dose-related manner. The decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin were not altered by the administration of naloxone in a dose of 2 mg/kg IV. Met-enkephalin decreased systemic arterial and hindquarters perfusion pressures and responses to the opioid receptor agonist were significantly reduced by naloxone, whereas decreases in systemic arterial pressure in response to the nitric oxide donor, DEA/NO, were not altered. The results of the present study show that decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not mediated by a naloxone-sensitive mechanism in the rat.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Female</subject><subject>Hindlimb - blood supply</subject><subject>Hindquarters vascular bed</subject><subject>Hypotensive response</subject><subject>Male</subject><subject>Naloxone</subject><subject>Naloxone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Nociceptin</subject><subject>Nociceptin (orphanin FQ)</subject><subject>Opioid Peptides - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Opioid - agonists</subject><subject>Regional Blood Flow - drug effects</subject><subject>Systemic vascular bed</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN1uEzEQhS0EKqHwCJV8heBiwfbu-ucKReWnlapQtb23nPFENdrYqe1F5AF4b3aTqLfczEhzzpnRfIRccPaJMy4_3zNuZGOU5h-M-sgYV7oRL8iCa9U2PZfmJVk8W16TN6X8Yox1ndFn5My0RjLJF-TvV4SMrmChIdL7fam4DUCXuWIObqAuenoVon8a3Twq9BbzZiwhRXqbsZQx4xy8w7JLsSCtia4SBMBdncbLSV2lSq_jY1iHip6u93TlhvQnxUOuPiK9c_UtebVxQ8F3p35OHr5_e7i8am5-_ri-XN400EpWG28ME1oAgFR9y8BwBSCQQ6s8AyUB1g6dUFq3XHjWeSHQe-y5F5pr2Z6T98e1u5yeRizVbkMBHAYXMY3FKtP1WnSzsT8aIadSMm7sLoety3vLmZ3p2wN9O6Odij3Qt2LKXZwOjOst-ufUCfekfznqOD35O2C2BQJGQB8yQrU-hf9c-AcR0JYk</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Czapla, M.A</creator><creator>Champion, H.C</creator><creator>Kadowitz, P.J</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Decreases in Systemic Arterial and Hindquarters Perfusion Pressure in Response to Nociceptin Are Not Inhibited by Naloxone in the Rat</title><author>Czapla, M.A ; Champion, H.C ; Kadowitz, P.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-d990282ccc67530c917cc2e1c37d0c76ccbaea2788312d04d22edde51d281863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Female</topic><topic>Hindlimb - blood supply</topic><topic>Hindquarters vascular bed</topic><topic>Hypotensive response</topic><topic>Male</topic><topic>Naloxone</topic><topic>Naloxone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Nociceptin</topic><topic>Nociceptin (orphanin FQ)</topic><topic>Opioid Peptides - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Opioid - agonists</topic><topic>Regional Blood Flow - drug effects</topic><topic>Systemic vascular bed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Czapla, M.A</creatorcontrib><creatorcontrib>Champion, H.C</creatorcontrib><creatorcontrib>Kadowitz, P.J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Czapla, M.A</au><au>Champion, H.C</au><au>Kadowitz, P.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreases in Systemic Arterial and Hindquarters Perfusion Pressure in Response to Nociceptin Are Not Inhibited by Naloxone in the Rat</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1997</date><risdate>1997</risdate><volume>18</volume><issue>8</issue><spage>1197</spage><epage>1200</epage><pages>1197-1200</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>Czapla, M. A., H. C. Champion and P. J. Kadowitz.
Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat.
Peptides 18(8) 1197–1200, 1997.—Nociceptin, the endogenous ligand for the ORL
1 receptor, has been shown to decrease systemic arterial and hindquarters perfusion pressures in the rat. The present study was undertaken to determine if decreases in systemic arterial and hindquarters perfusion pressures, in response to nociceptin, are mediated by a naloxone-sensitive mechanism. Injections of nociceptin decreased systemic arterial and hindquarters perfusion pressures in a dose-related manner. The decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin were not altered by the administration of naloxone in a dose of 2 mg/kg IV. Met-enkephalin decreased systemic arterial and hindquarters perfusion pressures and responses to the opioid receptor agonist were significantly reduced by naloxone, whereas decreases in systemic arterial pressure in response to the nitric oxide donor, DEA/NO, were not altered. The results of the present study show that decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not mediated by a naloxone-sensitive mechanism in the rat.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9396061</pmid><doi>10.1016/S0196-9781(97)00178-2</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1997, Vol.18 (8), p.1197-1200 |
| issn | 0196-9781 1873-5169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79458246 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Blood Pressure - drug effects Female Hindlimb - blood supply Hindquarters vascular bed Hypotensive response Male Naloxone Naloxone - pharmacology Narcotic Antagonists - pharmacology Nociceptin Nociceptin (orphanin FQ) Opioid Peptides - pharmacology Rats Rats, Sprague-Dawley Receptors, Opioid - agonists Regional Blood Flow - drug effects Systemic vascular bed |
| title | Decreases in Systemic Arterial and Hindquarters Perfusion Pressure in Response to Nociceptin Are Not Inhibited by Naloxone in the Rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T11%3A23%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreases%20in%20Systemic%20Arterial%20and%20Hindquarters%20Perfusion%20Pressure%20in%20Response%20to%20Nociceptin%20Are%20Not%20Inhibited%20by%20Naloxone%20in%20the%20Rat&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Czapla,%20M.A&rft.date=1997&rft.volume=18&rft.issue=8&rft.spage=1197&rft.epage=1200&rft.pages=1197-1200&rft.issn=0196-9781&rft.eissn=1873-5169&rft_id=info:doi/10.1016/S0196-9781(97)00178-2&rft_dat=%3Cproquest_cross%3E79458246%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79458246&rft_id=info:pmid/9396061&rft_els_id=S0196978197001782&rfr_iscdi=true |