Targeted Ablation of the Murine alpha-Tropomyosin Gene

We created a mouse that lacks a functional alpha-tropomyosin gene using gene targeting in embryonic stem cells and blastocyst-mediated transgenesis. Homozygous alpha-tropomyosin "knockout" mice die between embryonic day 9.5 and 13.5 and lack alpha-tropomyosin mRNA. Heterozygous alpha-tropo...

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Veröffentlicht in:	Circulation research 1997-12, Vol.81 (6), p.1005-1010
Hauptverfasser:	Blanchard, Edward M, Iizuka, Kenji, Christe, Michael, Conner, David A, Geisterfer-Lowrance, Anja, Schoen, Frederick J, Maughan, David W, Seidman, Christine E, Seidman, J.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Contractile proteins Fundamental and applied biological sciences. Psychology Gene Targeting Holoproteins Male Mice Mice, Knockout Myocardium - pathology Proteins Tropomyosin - genetics Tropomyosin - physiology
Online-Zugang:	Volltext
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