Modulation of porcine granulosa cell functions by interleukin-1

Increasing evidence suggests that functions of the immune system and gonads are closely related with each other. In cultures of granulosa and luteal cells, macrophages have been shown to modulate steroidogenic functions. In this paper we present the modulatory effects of interleukin-1, a cytokine pr...

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Veröffentlicht in:Steroids 1989-11, Vol.54 (5), p.543-552
Hauptverfasser: Mori, Takahide, Fukuoka, Masatsune, Yasuda, Keiko, Takakura, Kenji, Iwai, Toshiko, Taii, Shunzo
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container_end_page 552
container_issue 5
container_start_page 543
container_title Steroids
container_volume 54
creator Mori, Takahide
Fukuoka, Masatsune
Yasuda, Keiko
Takakura, Kenji
Iwai, Toshiko
Taii, Shunzo
description Increasing evidence suggests that functions of the immune system and gonads are closely related with each other. In cultures of granulosa and luteal cells, macrophages have been shown to modulate steroidogenic functions. In this paper we present the modulatory effects of interleukin-1, a cytokine produced predominantly by activated macrophages, on gonadotropin-induced differentiation, as well as growth of cultured porcine granulosa cells.
doi_str_mv 10.1016/0039-128X(89)90046-9
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subjects Animals
Cell Differentiation
Cells, Cultured
Cyclic AMP - metabolism
Dose-Response Relationship, Drug
Female
Follicle Stimulating Hormone - pharmacology
Granulosa Cells - drug effects
Granulosa Cells - physiology
Interleukin-1 - administration & dosage
Interleukin-1 - pharmacology
Luteinizing Hormone - pharmacology
Progesterone - antagonists & inhibitors
Progesterone - metabolism
Swine
title Modulation of porcine granulosa cell functions by interleukin-1
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