Interleukin-8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis or idiopathic pulmonary fibrosis
This study was designed to clarify the contribution of IL-8 as a specific neutrophil chemotactic factor in the human respiratory tract in various pulmonary diseases. The neutrophil chemotactic activity (NCA), neutrophil counts and IL-8 concentration in the bronchoalveolar lavage fluid (BALF) obtaine...
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| Veröffentlicht in: | The journal of medical investigation 1997-08, Vol.44 (1-2), p.53-58 |
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| creator | Ogushi, F Tani, K Maniwa, K Ichikawa, W Tada, H Kawano, T Sone, S |
| description | This study was designed to clarify the contribution of IL-8 as a specific neutrophil chemotactic factor in the human respiratory tract in various pulmonary diseases. The neutrophil chemotactic activity (NCA), neutrophil counts and IL-8 concentration in the bronchoalveolar lavage fluid (BALF) obtained from normal volunteers (NV), control patients (CP), patients with diffuse panbronchiolitis (DPB) and patients with idiopathic pulmonary fibrosis (IPF) were examined. Neutrophil counts, NCA and IL-8 concentration in BALF obtained from patients with DPB or IPF was significantly higher than that from NV or CP. The IL-8 concentration correlated with neutrophil count and also correlated with NCA in BALF from patients with IPF, whereas there was no correlation between these factors in BALF from DPB. These results suggest that the contribution of IL-8 to neutrophil accumulation of the lower respiratory tract is different between IPF and DPB. |
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These results suggest that the contribution of IL-8 to neutrophil accumulation of the lower respiratory tract is different between IPF and DPB.</description><subject>Blood Cell Count</subject><subject>Bronchoalveolar Lavage</subject><subject>Chemotaxis</subject><subject>Humans</subject><subject>Interleukin-8 - metabolism</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>Neutrophils - pathology</subject><subject>Pulmonary Fibrosis - immunology</subject><subject>Pulmonary Fibrosis - metabolism</subject><subject>Pulmonary Fibrosis - pathology</subject><issn>1343-1420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkE1LxDAYhHNQ1nX1Jwg5eSukTdKmR1n8WFjwoueSNG_cV9OkNs2q_97C7mlgeGYY5oKsSy54UYqKXZHrlD4Z41xKuSKrlreyKdWa_O7CDJOH_IWhUBQDNVMM_SFqf4To9US9PuoPoM5ntDQ6OuoZIcyJ_uB8oBadywkWN5yCGD3OmGicKFqMC33Ano7ZDzHo6Y86XLiE6YZcOu0T3J51Q96fHt-2L8X-9Xm3fdgXoZRsLnhdG9Ua29eVEbIx0nBVicqBMqwqTa8E1KJl2hrOreCmgd4paerGQaVqpviG3J96xyl-Z0hzN2DqwXsdIObUNa2QQjV8Ae_OYDYD2G6ccFgGd-er-D-Vzmdw</recordid><startdate>199708</startdate><enddate>199708</enddate><creator>Ogushi, F</creator><creator>Tani, K</creator><creator>Maniwa, K</creator><creator>Ichikawa, W</creator><creator>Tada, H</creator><creator>Kawano, T</creator><creator>Sone, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199708</creationdate><title>Interleukin-8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis or idiopathic pulmonary fibrosis</title><author>Ogushi, F ; Tani, K ; Maniwa, K ; Ichikawa, W ; Tada, H ; Kawano, T ; Sone, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n150t-366b89bdc62b457b5b38242fe8b021bc84e6490adb33d43b7ecf85b67fe286083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Blood Cell Count</topic><topic>Bronchoalveolar Lavage</topic><topic>Chemotaxis</topic><topic>Humans</topic><topic>Interleukin-8 - metabolism</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - metabolism</topic><topic>Neutrophils - pathology</topic><topic>Pulmonary Fibrosis - immunology</topic><topic>Pulmonary Fibrosis - metabolism</topic><topic>Pulmonary Fibrosis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogushi, F</creatorcontrib><creatorcontrib>Tani, K</creatorcontrib><creatorcontrib>Maniwa, K</creatorcontrib><creatorcontrib>Ichikawa, W</creatorcontrib><creatorcontrib>Tada, H</creatorcontrib><creatorcontrib>Kawano, T</creatorcontrib><creatorcontrib>Sone, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of medical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogushi, F</au><au>Tani, K</au><au>Maniwa, K</au><au>Ichikawa, W</au><au>Tada, H</au><au>Kawano, T</au><au>Sone, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis or idiopathic pulmonary fibrosis</atitle><jtitle>The journal of medical investigation</jtitle><addtitle>J Med Invest</addtitle><date>1997-08</date><risdate>1997</risdate><volume>44</volume><issue>1-2</issue><spage>53</spage><epage>58</epage><pages>53-58</pages><issn>1343-1420</issn><abstract>This study was designed to clarify the contribution of IL-8 as a specific neutrophil chemotactic factor in the human respiratory tract in various pulmonary diseases. 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| ispartof | The journal of medical investigation, 1997-08, Vol.44 (1-2), p.53-58 |
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| source | MEDLINE; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals |
| subjects | Blood Cell Count Bronchoalveolar Lavage Chemotaxis Humans Interleukin-8 - metabolism Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology Pulmonary Fibrosis - immunology Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology |
| title | Interleukin-8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis or idiopathic pulmonary fibrosis |
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