A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis
The genetic alteration of p53 is associated with neovascularization during progression of glioma to its more malignant form, glioblastoma. Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a...
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| Veröffentlicht in: | Oncogene 1997-10, Vol.15 (18), p.2145-2150 |
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| creator | NISHIMORI, H SHIRATSUCHI, T TOKINO, T URANO, T KIMURA, Y KIYONO, K TATSUMI, K YOSHIDA, S ONO, M KUWANO, M NAKAMURA, Y |
| description | The genetic alteration of p53 is associated with neovascularization during progression of glioma to its more malignant form, glioblastoma. Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a 1584-amino-acid product containing five thrombospondin type 1 (TSP-type 1) repeats and is specifically expressed in the brain. A recombinant protein corresponding to the TSP-type 1 repeats of this gene product inhibited in vivo neovascularization induced by bFGF in the rat cornea. The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53. |
| doi_str_mv | 10.1038/sj.onc.1201542 |
| format | Article |
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Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a 1584-amino-acid product containing five thrombospondin type 1 (TSP-type 1) repeats and is specifically expressed in the brain. A recombinant protein corresponding to the TSP-type 1 repeats of this gene product inhibited in vivo neovascularization induced by bFGF in the rat cornea. The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1201542</identifier><identifier>PMID: 9393972</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Amino Acid Sequence ; Angiogenesis ; Angiogenesis inhibitors ; Animals ; Biological and medical sciences ; Brain Neoplasms - blood supply ; Brain Neoplasms - metabolism ; Cell lines ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cornea ; DNA, Neoplasm - genetics ; DNA, Neoplasm - isolation & purification ; Fibroblast growth factor 2 ; Fundamental and applied biological sciences. Psychology ; Genes, p53 - physiology ; Glioblastoma ; Glioblastoma - blood supply ; Glioblastoma - metabolism ; Glioma ; Humans ; Molecular and cellular biology ; Molecular Sequence Data ; Neovascularization, Pathologic - genetics ; Neovascularization, Pathologic - metabolism ; p53 Protein ; Rats ; Repetitive Sequences, Nucleic Acid ; Sequence Homology, Amino Acid ; Thrombospondin ; Thrombospondin 1 - genetics ; Transcriptional Activation ; Tumor Cells, Cultured ; Vascularization</subject><ispartof>Oncogene, 1997-10, Vol.15 (18), p.2145-2150</ispartof><rights>1998 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1997.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-af20ff94c6d8c5c2cb0fecc1b798d6ebed43a4ee50492b46782fd8365994b8a83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2074403$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9393972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NISHIMORI, H</creatorcontrib><creatorcontrib>SHIRATSUCHI, T</creatorcontrib><creatorcontrib>TOKINO, T</creatorcontrib><creatorcontrib>URANO, T</creatorcontrib><creatorcontrib>KIMURA, Y</creatorcontrib><creatorcontrib>KIYONO, K</creatorcontrib><creatorcontrib>TATSUMI, K</creatorcontrib><creatorcontrib>YOSHIDA, S</creatorcontrib><creatorcontrib>ONO, M</creatorcontrib><creatorcontrib>KUWANO, M</creatorcontrib><creatorcontrib>NAKAMURA, Y</creatorcontrib><title>A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>The genetic alteration of p53 is associated with neovascularization during progression of glioma to its more malignant form, glioblastoma. Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a 1584-amino-acid product containing five thrombospondin type 1 (TSP-type 1) repeats and is specifically expressed in the brain. A recombinant protein corresponding to the TSP-type 1 repeats of this gene product inhibited in vivo neovascularization induced by bFGF in the rat cornea. The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.</description><subject>Amino Acid Sequence</subject><subject>Angiogenesis</subject><subject>Angiogenesis inhibitors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - blood supply</subject><subject>Brain Neoplasms - metabolism</subject><subject>Cell lines</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Cornea</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - isolation & purification</subject><subject>Fibroblast growth factor 2</subject><subject>Fundamental and applied biological sciences. 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Action of oncogenes and antioncogenes</topic><topic>Cornea</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Neoplasm - isolation & purification</topic><topic>Fibroblast growth factor 2</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, p53 - physiology</topic><topic>Glioblastoma</topic><topic>Glioblastoma - blood supply</topic><topic>Glioblastoma - metabolism</topic><topic>Glioma</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>p53 Protein</topic><topic>Rats</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Sequence Homology, Amino Acid</topic><topic>Thrombospondin</topic><topic>Thrombospondin 1 - genetics</topic><topic>Transcriptional Activation</topic><topic>Tumor Cells, Cultured</topic><topic>Vascularization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NISHIMORI, H</creatorcontrib><creatorcontrib>SHIRATSUCHI, T</creatorcontrib><creatorcontrib>TOKINO, T</creatorcontrib><creatorcontrib>URANO, T</creatorcontrib><creatorcontrib>KIMURA, Y</creatorcontrib><creatorcontrib>KIYONO, K</creatorcontrib><creatorcontrib>TATSUMI, K</creatorcontrib><creatorcontrib>YOSHIDA, S</creatorcontrib><creatorcontrib>ONO, M</creatorcontrib><creatorcontrib>KUWANO, M</creatorcontrib><creatorcontrib>NAKAMURA, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NISHIMORI, H</au><au>SHIRATSUCHI, T</au><au>TOKINO, T</au><au>URANO, T</au><au>KIMURA, Y</au><au>KIYONO, K</au><au>TATSUMI, K</au><au>YOSHIDA, S</au><au>ONO, M</au><au>KUWANO, M</au><au>NAKAMURA, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis</atitle><jtitle>Oncogene</jtitle><addtitle>Oncogene</addtitle><date>1997-10</date><risdate>1997</risdate><volume>15</volume><issue>18</issue><spage>2145</spage><epage>2150</epage><pages>2145-2150</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><abstract>The genetic alteration of p53 is associated with neovascularization during progression of glioma to its more malignant form, glioblastoma. Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a 1584-amino-acid product containing five thrombospondin type 1 (TSP-type 1) repeats and is specifically expressed in the brain. A recombinant protein corresponding to the TSP-type 1 repeats of this gene product inhibited in vivo neovascularization induced by bFGF in the rat cornea. The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>9393972</pmid><doi>10.1038/sj.onc.1201542</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Angiogenesis Angiogenesis inhibitors Animals Biological and medical sciences Brain Neoplasms - blood supply Brain Neoplasms - metabolism Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cornea DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Fibroblast growth factor 2 Fundamental and applied biological sciences. Psychology Genes, p53 - physiology Glioblastoma Glioblastoma - blood supply Glioblastoma - metabolism Glioma Humans Molecular and cellular biology Molecular Sequence Data Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism p53 Protein Rats Repetitive Sequences, Nucleic Acid Sequence Homology, Amino Acid Thrombospondin Thrombospondin 1 - genetics Transcriptional Activation Tumor Cells, Cultured Vascularization |
| title | A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis |
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