Reaction of the bone structure to methotrexate-Palacos flow y. Experimental investigations in animals
With the combined osteosynthesis of pathological fractures in association with tumors and/or metastases in mind, E. Merck (Darmstadt, FRG) developed a bone cement containing a cytostatic agent, methotrexate-Palacos flow y (MTX-Pf). The animal-experimental study presented here investigates the tolera...
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| Veröffentlicht in: | Archives of Orthopaedic and Trauma Surgery 1989-01, Vol.108 (6), p.363-367 |
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| container_title | Archives of Orthopaedic and Trauma Surgery |
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| creator | Degreif, J Rudigier, J Rudig, L Wahlig, H Dingeldein, E |
| description | With the combined osteosynthesis of pathological fractures in association with tumors and/or metastases in mind, E. Merck (Darmstadt, FRG) developed a bone cement containing a cytostatic agent, methotrexate-Palacos flow y (MTX-Pf). The animal-experimental study presented here investigates the tolerability of MTX-Pf in the femurs of rabbits with lateral comparison. In these investigations we used both the concentration of 0.63% MTX, as is currently used in standard clinical surgery, as well as a much higher concentration of 2.5% MTX. The histological sections were investigated using microradiographic methods and provided no indication of any significant differences between the femora with the MTX-Pf implantation and those into which standard Palacos flow y had been implanted. |
| doi_str_mv | 10.1007/BF00932447 |
| format | Article |
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The histological sections were investigated using microradiographic methods and provided no indication of any significant differences between the femora with the MTX-Pf implantation and those into which standard Palacos flow y had been implanted.</description><identifier>ISSN: 0936-8051</identifier><identifier>ISSN: 0344-8444</identifier><identifier>EISSN: 1434-3916</identifier><identifier>DOI: 10.1007/BF00932447</identifier><identifier>PMID: 2619523</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Bone and Bones - drug effects ; Bone and Bones - pathology ; Bone Cements - pharmacology ; Bone Cements - therapeutic use ; Fracture Fixation, Intramedullary ; Fractures, Bone - surgery ; Methotrexate - pharmacology ; Methotrexate - therapeutic use ; Rabbits ; Wound Healing</subject><ispartof>Archives of Orthopaedic and Trauma Surgery, 1989-01, Vol.108 (6), p.363-367</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c271t-e00ad257bfda37a6aea9a896ae2754b4ba1ec34836cd1d1df365b833862980ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2619523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Degreif, J</creatorcontrib><creatorcontrib>Rudigier, J</creatorcontrib><creatorcontrib>Rudig, L</creatorcontrib><creatorcontrib>Wahlig, H</creatorcontrib><creatorcontrib>Dingeldein, E</creatorcontrib><title>Reaction of the bone structure to methotrexate-Palacos flow y. 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The histological sections were investigated using microradiographic methods and provided no indication of any significant differences between the femora with the MTX-Pf implantation and those into which standard Palacos flow y had been implanted.</description><subject>Animals</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - pathology</subject><subject>Bone Cements - pharmacology</subject><subject>Bone Cements - therapeutic use</subject><subject>Fracture Fixation, Intramedullary</subject><subject>Fractures, Bone - surgery</subject><subject>Methotrexate - pharmacology</subject><subject>Methotrexate - therapeutic use</subject><subject>Rabbits</subject><subject>Wound Healing</subject><issn>0936-8051</issn><issn>0344-8444</issn><issn>1434-3916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1Lw0AQxRdRaq1evAt78iCk7lc-9qilVaGgiJ7DJJnYSJKtuxtt_3u3tChzeMzwm8fMI-SSsylnLL29XzCmpVAqPSJjrqSKpObJMRmHaRJlLOan5My5T8a4yDQbkZFIuI6FHBN8RSh9Y3pqaupXSAvTI3XeDqUfLFJvaId-ZbzFDXiMXqCF0jhat-aHbqd0vlmjbTrsPbS06b_R-eYDdoYutBT6poPWnZOTOgheHHRC3hfzt9ljtHx-eJrdLaNSpNxHyBhUIk6LugKZQgIIGjIdVKSxKlQBHEupMpmUFQ9VyyQuMimzROiMAcoJud77rq35GsItede4EtsWejSDy1Ot4rAjA3izB0trnLNY5-vwBdhtzlm-yzT_zzTAVwfXoeiw-kMPIcpfDBtyyg</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>Degreif, J</creator><creator>Rudigier, J</creator><creator>Rudig, L</creator><creator>Wahlig, H</creator><creator>Dingeldein, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890101</creationdate><title>Reaction of the bone structure to methotrexate-Palacos flow y. 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| fulltext | fulltext |
| identifier | ISSN: 0936-8051 |
| ispartof | Archives of Orthopaedic and Trauma Surgery, 1989-01, Vol.108 (6), p.363-367 |
| issn | 0936-8051 0344-8444 1434-3916 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Bone and Bones - drug effects Bone and Bones - pathology Bone Cements - pharmacology Bone Cements - therapeutic use Fracture Fixation, Intramedullary Fractures, Bone - surgery Methotrexate - pharmacology Methotrexate - therapeutic use Rabbits Wound Healing |
| title | Reaction of the bone structure to methotrexate-Palacos flow y. Experimental investigations in animals |
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