Kinetics of the inhibition of mitochondrial respiration by NO

The kinetics of the inhibition of mitochondrial respiration by NO was examined in isolated mitochondria (here obtained from rat brown adipose tissue). The K i of NO for the inhibition was ∼27 nM; the IC 50 of NO increased in proportion to the square of an increase in O 2 tension. The K m of O 2 for...

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Veröffentlicht in:	FEBS letters 1997-11, Vol.417 (1), p.75-80
Hauptverfasser:	Koivisto, Ari, Matthias, Anita, Bronnikov, Gennady, Nedergaard, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - metabolism Animals Brown fat mitochondria Cytochrome c oxidase Female Hypoxia Kinetics Mitochondria - drug effects Mitochondria - metabolism Nitric oxide Nitric Oxide - pharmacology Non-shivering thermogenesis Oxygen Oxygen - metabolism Oxygen Consumption - drug effects Rats Rats, Sprague-Dawley
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