Intracellular localization of p53 tumor suppressor protein in γ-irradiated cells is cell cycle regulated and determined by the nucleus

DNA damage leads to the stabilization of p53 protein and its translocation to the nucleus, resulting in activation or suppression of p53-responsive genes. However, a significant proportion of cell nuclei remain negative for p53 and p53-inducible cyclin-dependent kinase inhibitor p21waf1 after a sing...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-12, Vol.57 (23), p.5217-5220
Hauptverfasser:	KOMAROVA, E. A, ZELNICK, C. R, CHIN, D, ZEREMSKI, M, GLEIBERMAN, A. S, BACUS, S. S, GUDKOV, A. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms Cell Cycle - physiology Cell Cycle - radiation effects Cell Fusion Cell Nucleus - metabolism Cell Nucleus - radiation effects Cyclin-Dependent Kinase Inhibitor p21 Cyclins - analysis Cyclins - biosynthesis Enzyme Inhibitors Female Fibroblasts Fibrosarcoma Gamma Rays Humans Medical sciences Polyethylene Glycols Radiation therapy and radiosensitizing agent Skin Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured Tumor Suppressor Protein p53 - analysis Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - radiation effects Tumors
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