Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor
We have previously cloned a human receptor recently shown to be a cofactor for entry of T-tropic HIV-1 strains into CD4+ cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny...
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| Veröffentlicht in: | Journal of neuroimmunology 1997-11, Vol.79 (2), p.148-154 |
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| container_title | Journal of neuroimmunology |
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| creator | Jazin, Elena E Söderström, Stine Ebendal, Ted Larhammar, Dan |
| description | We have previously cloned a human receptor recently shown to be a cofactor for entry of T-tropic HIV-1 strains into CD4+ cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny in the rat. The onset of mRNA expression is around embryonic day 9 and the mRNA expression is high in the thymus as well as proliferative areas of the brain during development. Our results suggest: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development. |
| doi_str_mv | 10.1016/S0165-5728(97)00117-3 |
| format | Article |
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Our results suggest: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(97)00117-3</identifier><identifier>PMID: 9394787</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>AIDS/HIV ; Animals ; Brain - embryology ; CXCR-4 ; Embryo, Mammalian - metabolism ; Embryonic and Fetal Development - physiology ; Fusin ; HIV ; Humans ; Immune System - embryology ; Lymphocyte chemoattractant ; Nervous System - embryology ; Rat development ; Rats ; Rats, Sprague-Dawley ; Receptor ; Receptors, CXCR4 - genetics ; RNA, Messenger - metabolism ; Sequence Homology</subject><ispartof>Journal of neuroimmunology, 1997-11, Vol.79 (2), p.148-154</ispartof><rights>1997 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-aa181e1abdfbf7d27333af193c48e5872665833aba931dd6b70ddff1e53cd73e3</citedby><cites>FETCH-LOGICAL-c509t-aa181e1abdfbf7d27333af193c48e5872665833aba931dd6b70ddff1e53cd73e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-5728(97)00117-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9394787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jazin, Elena E</creatorcontrib><creatorcontrib>Söderström, Stine</creatorcontrib><creatorcontrib>Ebendal, Ted</creatorcontrib><creatorcontrib>Larhammar, Dan</creatorcontrib><title>Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>We have previously cloned a human receptor recently shown to be a cofactor for entry of T-tropic HIV-1 strains into CD4+ cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny in the rat. The onset of mRNA expression is around embryonic day 9 and the mRNA expression is high in the thymus as well as proliferative areas of the brain during development. Our results suggest: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Brain - embryology</subject><subject>CXCR-4</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Embryonic and Fetal Development - physiology</subject><subject>Fusin</subject><subject>HIV</subject><subject>Humans</subject><subject>Immune System - embryology</subject><subject>Lymphocyte chemoattractant</subject><subject>Nervous System - embryology</subject><subject>Rat development</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor</subject><subject>Receptors, CXCR4 - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Homology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rHCEUhiWkbDZpf8LCXJX0wq6O4zhelbDkC0IL2zbkoiCOHhPDzrjRmZL8-7ofze3eKJ7znPPig9CMkq-U0Hr-Mx8cc1E251J8IYRSgdkRmtJGlLipSnqMpu_ICTpN6TlDnFVygiaSyUo0Yor-XHZtfAu9NwW8riOk5ENfBFcMT1B0y-8XhQtx-4h6KJ5CF1bhcYT_hBuT7-eLh8USV8XN7T2mhQk4goH1EOJH9MHpVYJP-_sM_b66_LW4wXc_rm8XF3fYcCIHrDVtKFDdWtc6YUvBGNOOSmaqBnj-Tl3zJpdaLRm1tm4FsdY5CpwZKxiwM_R5t3cdw8sIaVCdTwZWK91DGJMSsuKElPIgSOuS1GUlMsh3oIkhpQhOraPvdHxTlKiNfrXVrzZulRRqq1-xPDfbB4xtB_Z9au8797_t-pB1_PUQVTIeegPWZ2mDssEfSPgHfmyThg</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Jazin, Elena E</creator><creator>Söderström, Stine</creator><creator>Ebendal, Ted</creator><creator>Larhammar, Dan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19971101</creationdate><title>Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor</title><author>Jazin, Elena E ; Söderström, Stine ; Ebendal, Ted ; Larhammar, Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-aa181e1abdfbf7d27333af193c48e5872665833aba931dd6b70ddff1e53cd73e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Brain - embryology</topic><topic>CXCR-4</topic><topic>Embryo, Mammalian - metabolism</topic><topic>Embryonic and Fetal Development - physiology</topic><topic>Fusin</topic><topic>HIV</topic><topic>Humans</topic><topic>Immune System - embryology</topic><topic>Lymphocyte chemoattractant</topic><topic>Nervous System - embryology</topic><topic>Rat development</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor</topic><topic>Receptors, CXCR4 - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Homology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jazin, Elena E</creatorcontrib><creatorcontrib>Söderström, Stine</creatorcontrib><creatorcontrib>Ebendal, Ted</creatorcontrib><creatorcontrib>Larhammar, Dan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jazin, Elena E</au><au>Söderström, Stine</au><au>Ebendal, Ted</au><au>Larhammar, Dan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>79</volume><issue>2</issue><spage>148</spage><epage>154</epage><pages>148-154</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>We have previously cloned a human receptor recently shown to be a cofactor for entry of T-tropic HIV-1 strains into CD4+ cells, now named fusin. 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| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1997-11, Vol.79 (2), p.148-154 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | AIDS/HIV Animals Brain - embryology CXCR-4 Embryo, Mammalian - metabolism Embryonic and Fetal Development - physiology Fusin HIV Humans Immune System - embryology Lymphocyte chemoattractant Nervous System - embryology Rat development Rats Rats, Sprague-Dawley Receptor Receptors, CXCR4 - genetics RNA, Messenger - metabolism Sequence Homology |
| title | Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor |
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