Expression of multiple endocrine neoplasia 2B RET in neuroblastoma cells alters cell adhesion in vitro, enhances metastatic behavior in vivo, and activates Jun kinase

Point mutations, deletions, and recombinations of the RET proto-oncogene are associated with several inherited human diseases of neural crest-derived cells: Hirschsprung's disease, familial medullary thyroid carcinoma, and the multiple endocrine neoplasia (MEN) syndromes, types 2A and 2B. RET e...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-12, Vol.57 (23), p.5399-5405
Hauptverfasser:	MARSHALL, G. M, PEASTON, A. E, PONDER, B. A. J, HANCOCK, J. F, HOCKER, J. E, SMITH, S. A, HANSFORD, L. M, TOBIAS, V, NORRIS, M. D, HABER, M, SMITH, D. P, LORENZO, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Biological and medical sciences Cell Division Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes COS Cells Drosophila Proteins Fundamental and applied biological sciences. Psychology Humans Lung Neoplasms - pathology Lung Neoplasms - secondary Mice Mice, Nude Molecular and cellular biology Multiple Endocrine Neoplasia Type 2a - genetics Multiple Endocrine Neoplasia Type 2b - genetics Multiple Endocrine Neoplasia Type 2b - metabolism Multiple Endocrine Neoplasia Type 2b - pathology Multiple Endocrine Neoplasia Type 2b - secondary Neoplasm Metastasis Neural Crest - cytology Neural Crest - metabolism Neuroblastoma - pathology Point Mutation Polymerase Chain Reaction Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-ret Proto-Oncogenes Receptor Protein-Tyrosine Kinases - biosynthesis Recombinant Proteins - biosynthesis Transfection Transplantation, Heterologous Tumor Cells, Cultured
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