Modulation of Microglial form and Immune Function by Factors Released from Goldfish Optic Nerves
Activation of microglia is associated with neural damage and may aid repair of the CNS. To begin to investigate their role, microglia purified from mouse brain were grown in media conditioned (CM) by goldfish optic nerve (GFON), optic tectum (GFOT), vagal lobe, telencephalon and cerebellum, and medi...
Gespeichert in:
| Veröffentlicht in: | International journal of neuroscience 1997-01, Vol.91 (1-2), p.133-146 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 146 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 133 |
| container_title | International journal of neuroscience |
| container_volume | 91 |
| creator | Perry, G. W. Keane, Robert W. |
| description | Activation of microglia is associated with neural damage and may aid repair of the CNS. To begin to investigate their role, microglia purified from mouse brain were grown in media conditioned (CM) by goldfish optic nerve (GFON), optic tectum (GFOT), vagal lobe, telencephalon and cerebellum, and medium conditioned by rat optic nerves (RON). Microglia maintained in GFON- or GFOT-CM assumed an ameboid morphology, whereas microglia grown in media conditioned by the other neural tissues produced long, crenellated processes that resembled the ramified microglial form. Microglia maintained in all types of CM functioned as antigen presenting cells in a MHC-restricted manner when tested on conalbumin-specific Thelper (Th) cells, except for microglia maintained in GFON-and GFOT-CM. These studies suggest that GFON, in contrast to RON, produces a substance(s) that affects microglial morphology and immune reactivity, and may promote the vigorous regeneration seen in Gfon after damage. |
| doi_str_mv | 10.3109/00207459708986371 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79447984</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16442286</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-3c3375036b3c0a6aa5489845b7e566f2ff10c827a108b52a4ecb36e4e7efb9943</originalsourceid><addsrcrecordid>eNqFkc2KFDEUhYMoY9POA7gQshB3pflPBd3IYI8DMw6IrstbqcSOpCptUqX025u22wERxlW43O8ccs9B6CklLzkl5hUhjGghjSataRXX9AFaUal4I5k2D9HqsG8qIB6j81JCX2duDGvbM3RmuBGM0RX6cpOGJcIc0oSTxzfB5vQ1BojYpzximAZ8NY7L5PBmmexvrN_jDdg55YI_uuiguAH7nEZ8meLgQ9ni290cLP7g8g9XnqBHHmJx56d3jT5v3n26eN9c315eXby9bqxQdG645VxLwlXPLQEFIEW9SsheO6mUZ95TYlumgZK2lwyEsz1XTjjtfG-M4Gv04ui7y-n74srcjaFYFyNMLi2l00YIXR3_C1IlajQ10DWiR7BGUkp2vtvlMELed5R0hwa6fxqommcn86Uf3XCnOOVd989PeygWos8w2VDuMNZKppiu2JsjFqZDDfAz5Th0M-xjyn80_L5fvP5LvnUQ562F7LpvaclT7eGeG34B7e6yOQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16442286</pqid></control><display><type>article</type><title>Modulation of Microglial form and Immune Function by Factors Released from Goldfish Optic Nerves</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>Perry, G. W. ; Keane, Robert W.</creator><creatorcontrib>Perry, G. W. ; Keane, Robert W.</creatorcontrib><description>Activation of microglia is associated with neural damage and may aid repair of the CNS. To begin to investigate their role, microglia purified from mouse brain were grown in media conditioned (CM) by goldfish optic nerve (GFON), optic tectum (GFOT), vagal lobe, telencephalon and cerebellum, and medium conditioned by rat optic nerves (RON). Microglia maintained in GFON- or GFOT-CM assumed an ameboid morphology, whereas microglia grown in media conditioned by the other neural tissues produced long, crenellated processes that resembled the ramified microglial form. Microglia maintained in all types of CM functioned as antigen presenting cells in a MHC-restricted manner when tested on conalbumin-specific Thelper (Th) cells, except for microglia maintained in GFON-and GFOT-CM. These studies suggest that GFON, in contrast to RON, produces a substance(s) that affects microglial morphology and immune reactivity, and may promote the vigorous regeneration seen in Gfon after damage.</description><identifier>ISSN: 0020-7454</identifier><identifier>EISSN: 1563-5279</identifier><identifier>EISSN: 1543-5245</identifier><identifier>DOI: 10.3109/00207459708986371</identifier><identifier>PMID: 9394221</identifier><identifier>CODEN: IJNUB7</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Animals ; Antigen Presentation ; Biological and medical sciences ; Carassius auratus ; Cell Size - immunology ; Cells, Cultured ; Culture Media, Conditioned ; Cytokines - immunology ; Cytokines - metabolism ; Development. Senescence. Regeneration. Transplantation ; Fluorescent Antibody Technique ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Goldfish ; Histocompatibility Antigens Class II - immunology ; immune reactivity ; MHC expression ; Mice ; Mice, Inbred CBA ; Microglia ; Microglia - cytology ; Microglia - immunology ; Nerve Tissue - immunology ; Nerve Tissue - metabolism ; Neuroimmunomodulation ; optic nerve ; Optic Nerve - immunology ; Optic Nerve - metabolism ; rat ; Rats ; T-Lymphocytes, Helper-Inducer - immunology ; Vertebrates: nervous system and sense organs</subject><ispartof>International journal of neuroscience, 1997-01, Vol.91 (1-2), p.133-146</ispartof><rights>1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-3c3375036b3c0a6aa5489845b7e566f2ff10c827a108b52a4ecb36e4e7efb9943</citedby><cites>FETCH-LOGICAL-c461t-3c3375036b3c0a6aa5489845b7e566f2ff10c827a108b52a4ecb36e4e7efb9943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00207459708986371$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00207459708986371$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2852627$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9394221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perry, G. W.</creatorcontrib><creatorcontrib>Keane, Robert W.</creatorcontrib><title>Modulation of Microglial form and Immune Function by Factors Released from Goldfish Optic Nerves</title><title>International journal of neuroscience</title><addtitle>Int J Neurosci</addtitle><description>Activation of microglia is associated with neural damage and may aid repair of the CNS. To begin to investigate their role, microglia purified from mouse brain were grown in media conditioned (CM) by goldfish optic nerve (GFON), optic tectum (GFOT), vagal lobe, telencephalon and cerebellum, and medium conditioned by rat optic nerves (RON). Microglia maintained in GFON- or GFOT-CM assumed an ameboid morphology, whereas microglia grown in media conditioned by the other neural tissues produced long, crenellated processes that resembled the ramified microglial form. Microglia maintained in all types of CM functioned as antigen presenting cells in a MHC-restricted manner when tested on conalbumin-specific Thelper (Th) cells, except for microglia maintained in GFON-and GFOT-CM. These studies suggest that GFON, in contrast to RON, produces a substance(s) that affects microglial morphology and immune reactivity, and may promote the vigorous regeneration seen in Gfon after damage.</description><subject>Animals</subject><subject>Antigen Presentation</subject><subject>Biological and medical sciences</subject><subject>Carassius auratus</subject><subject>Cell Size - immunology</subject><subject>Cells, Cultured</subject><subject>Culture Media, Conditioned</subject><subject>Cytokines - immunology</subject><subject>Cytokines - metabolism</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Fluorescent Antibody Technique</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Goldfish</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>immune reactivity</subject><subject>MHC expression</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Microglia</subject><subject>Microglia - cytology</subject><subject>Microglia - immunology</subject><subject>Nerve Tissue - immunology</subject><subject>Nerve Tissue - metabolism</subject><subject>Neuroimmunomodulation</subject><subject>optic nerve</subject><subject>Optic Nerve - immunology</subject><subject>Optic Nerve - metabolism</subject><subject>rat</subject><subject>Rats</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0020-7454</issn><issn>1563-5279</issn><issn>1543-5245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEUhYMoY9POA7gQshB3pflPBd3IYI8DMw6IrstbqcSOpCptUqX025u22wERxlW43O8ccs9B6CklLzkl5hUhjGghjSataRXX9AFaUal4I5k2D9HqsG8qIB6j81JCX2duDGvbM3RmuBGM0RX6cpOGJcIc0oSTxzfB5vQ1BojYpzximAZ8NY7L5PBmmexvrN_jDdg55YI_uuiguAH7nEZ8meLgQ9ni290cLP7g8g9XnqBHHmJx56d3jT5v3n26eN9c315eXby9bqxQdG645VxLwlXPLQEFIEW9SsheO6mUZ95TYlumgZK2lwyEsz1XTjjtfG-M4Gv04ui7y-n74srcjaFYFyNMLi2l00YIXR3_C1IlajQ10DWiR7BGUkp2vtvlMELed5R0hwa6fxqommcn86Uf3XCnOOVd989PeygWos8w2VDuMNZKppiu2JsjFqZDDfAz5Th0M-xjyn80_L5fvP5LvnUQ562F7LpvaclT7eGeG34B7e6yOQ</recordid><startdate>19970101</startdate><enddate>19970101</enddate><creator>Perry, G. W.</creator><creator>Keane, Robert W.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>19970101</creationdate><title>Modulation of Microglial form and Immune Function by Factors Released from Goldfish Optic Nerves</title><author>Perry, G. W. ; Keane, Robert W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-3c3375036b3c0a6aa5489845b7e566f2ff10c827a108b52a4ecb36e4e7efb9943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antigen Presentation</topic><topic>Biological and medical sciences</topic><topic>Carassius auratus</topic><topic>Cell Size - immunology</topic><topic>Cells, Cultured</topic><topic>Culture Media, Conditioned</topic><topic>Cytokines - immunology</topic><topic>Cytokines - metabolism</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Fluorescent Antibody Technique</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Goldfish</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>immune reactivity</topic><topic>MHC expression</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Microglia</topic><topic>Microglia - cytology</topic><topic>Microglia - immunology</topic><topic>Nerve Tissue - immunology</topic><topic>Nerve Tissue - metabolism</topic><topic>Neuroimmunomodulation</topic><topic>optic nerve</topic><topic>Optic Nerve - immunology</topic><topic>Optic Nerve - metabolism</topic><topic>rat</topic><topic>Rats</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perry, G. W.</creatorcontrib><creatorcontrib>Keane, Robert W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perry, G. W.</au><au>Keane, Robert W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of Microglial form and Immune Function by Factors Released from Goldfish Optic Nerves</atitle><jtitle>International journal of neuroscience</jtitle><addtitle>Int J Neurosci</addtitle><date>1997-01-01</date><risdate>1997</risdate><volume>91</volume><issue>1-2</issue><spage>133</spage><epage>146</epage><pages>133-146</pages><issn>0020-7454</issn><eissn>1563-5279</eissn><eissn>1543-5245</eissn><coden>IJNUB7</coden><abstract>Activation of microglia is associated with neural damage and may aid repair of the CNS. To begin to investigate their role, microglia purified from mouse brain were grown in media conditioned (CM) by goldfish optic nerve (GFON), optic tectum (GFOT), vagal lobe, telencephalon and cerebellum, and medium conditioned by rat optic nerves (RON). Microglia maintained in GFON- or GFOT-CM assumed an ameboid morphology, whereas microglia grown in media conditioned by the other neural tissues produced long, crenellated processes that resembled the ramified microglial form. Microglia maintained in all types of CM functioned as antigen presenting cells in a MHC-restricted manner when tested on conalbumin-specific Thelper (Th) cells, except for microglia maintained in GFON-and GFOT-CM. These studies suggest that GFON, in contrast to RON, produces a substance(s) that affects microglial morphology and immune reactivity, and may promote the vigorous regeneration seen in Gfon after damage.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>9394221</pmid><doi>10.3109/00207459708986371</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7454 |
| ispartof | International journal of neuroscience, 1997-01, Vol.91 (1-2), p.133-146 |
| issn | 0020-7454 1563-5279 1543-5245 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79447984 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Antigen Presentation Biological and medical sciences Carassius auratus Cell Size - immunology Cells, Cultured Culture Media, Conditioned Cytokines - immunology Cytokines - metabolism Development. Senescence. Regeneration. Transplantation Fluorescent Antibody Technique Freshwater Fundamental and applied biological sciences. Psychology Goldfish Histocompatibility Antigens Class II - immunology immune reactivity MHC expression Mice Mice, Inbred CBA Microglia Microglia - cytology Microglia - immunology Nerve Tissue - immunology Nerve Tissue - metabolism Neuroimmunomodulation optic nerve Optic Nerve - immunology Optic Nerve - metabolism rat Rats T-Lymphocytes, Helper-Inducer - immunology Vertebrates: nervous system and sense organs |
| title | Modulation of Microglial form and Immune Function by Factors Released from Goldfish Optic Nerves |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A31%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modulation%20of%20Microglial%20form%20and%20Immune%20Function%20by%20Factors%20Released%20from%20Goldfish%20Optic%20Nerves&rft.jtitle=International%20journal%20of%20neuroscience&rft.au=Perry,%20G.%20W.&rft.date=1997-01-01&rft.volume=91&rft.issue=1-2&rft.spage=133&rft.epage=146&rft.pages=133-146&rft.issn=0020-7454&rft.eissn=1563-5279&rft.coden=IJNUB7&rft_id=info:doi/10.3109/00207459708986371&rft_dat=%3Cproquest_cross%3E16442286%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16442286&rft_id=info:pmid/9394221&rfr_iscdi=true |