$Leukocyte Reduction and Ultraviolet B Irradiation of Platelets to Prevent Alloimmunization and Refractoriness to Platelet Transfusions$

Leukocyte Reduction and Ultraviolet B Irradiation of Platelets to Prevent Alloimmunization and Refractoriness to Platelet Transfusions

Antibodies against alloantigens on donor platelets are a major cause of refractoriness to platelet transfusions in patients with thrombocytopenia. These antibodies usually arise in response to HLA class I antigens on leukocytes and platelets, and they may result from maternal–fetal incompatibility o...

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Veröffentlicht in:	The New England journal of medicine 1997-12, Vol.337 (26), p.1861-1870
Hauptverfasser:	McFarland, J, Menitove, J, Kagen, L, Braine, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antigens, Human Platelet - immunology Biological and medical sciences Blood Component Removal Blood Group Incompatibility - prevention & control Blood Platelets - immunology Blood Platelets - radiation effects Double-Blind Method Female Filtration Hematologic and hematopoietic diseases Humans Isoantibodies - blood Leukemia Leukemia, Myeloid - complications Leukemia, Myeloid - immunology Leukemia, Myeloid - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes Leukocytes - immunology Leukocytes - radiation effects Lymphocytes - immunology Male Medical sciences Middle Aged Multivariate Analysis Platelet Transfusion - adverse effects Thrombocytopenia - etiology Thrombocytopenia - therapy Ultraviolet radiation Ultraviolet Rays
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