THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON VASOACTIVE INTESTINAL PEPTIDE IN CEREBRAL ISCHEMIA:AN ANIMAL EXPERIMENT
The levels of vasoactive intestinal peptide(VIP)in three regions of rat brain were assayed in 62 rats.Bilateral common carotid artery ligation was donein 50 rats.Half an hour before ligation 26 rats weregiven 10 g/kg of Radix Salviae Miltiorrhizae(RSM);24 rats were given same volume of normalsaline...
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| Veröffentlicht in: | Journal of traditional Chinese medicine 1989-09, Vol.9 (3), p.203-206 |
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| creator | 匡培根 吴卫平 张凤英 刘洁晓 蒲传强 |
| description | The levels of vasoactive intestinal peptide(VIP)in three regions of rat brain were assayed in 62 rats.Bilateral common carotid artery ligation was donein 50 rats.Half an hour before ligation 26 rats weregiven 10 g/kg of Radix Salviae Miltiorrhizae(RSM);24 rats were given same volume of normalsaline as controls.A sham operation wasdone in 12 rats.Half an hour(n=30)and 3hours(n=32)after operation,the rats were quicklydecapitated.VIP levels were assayed in cerebralcortex,hippocampus and caudate nucleus,in salin-treated animals,VIP levels of cerebral cortex andcaudate nucleus at 3 hour group were significantlydecreased compared with the sham-operated group.No significant difference was found between RSM-treated and sham-operated groups.The preliminaryresults suggest that VIP may be involved in thepathophysiological procedures of cerebral ischemiaand RSM may attenuate the dysfunction of VIPduring cerebral ischemia. |
| format | Article |
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metabolism ; carotid ; cortex ; Drug Combinations - pharmacology ; Drug Combinations - therapeutic use ; Drugs, Chinese Herbal ; hippocampus ; Ischemic Attack, Transient - drug therapy ; Ischemic Attack, Transient - metabolism ; ligation ; Male ; nucleus ; operated ; Phenanthrolines - pharmacology ; Phenanthrolines - therapeutic use ; Plant Extracts ; Radix ; Rats ; Rats, Inbred Strains ; saline ; vasoactive ; Vasoactive Intestinal Peptide - metabolism</subject><ispartof>Journal of traditional Chinese medicine, 1989-09, Vol.9 (3), p.203-206</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86801X/86801X.jpg</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2615458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>匡培根 吴卫平 张凤英 刘洁晓 蒲传强</creatorcontrib><title>THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON VASOACTIVE INTESTINAL PEPTIDE IN CEREBRAL ISCHEMIA:AN ANIMAL EXPERIMENT</title><title>Journal of traditional Chinese medicine</title><addtitle>Journal of Traditional Chinese Medicine</addtitle><description>The levels of vasoactive intestinal peptide(VIP)in three regions of rat brain were assayed in 62 rats.Bilateral common carotid artery ligation was donein 50 rats.Half an hour before ligation 26 rats weregiven 10 g/kg of Radix Salviae Miltiorrhizae(RSM);24 rats were given same volume of normalsaline as controls.A sham operation wasdone in 12 rats.Half an hour(n=30)and 3hours(n=32)after operation,the rats were quicklydecapitated.VIP levels were assayed in cerebralcortex,hippocampus and caudate nucleus,in salin-treated animals,VIP levels of cerebral cortex andcaudate nucleus at 3 hour group were significantlydecreased compared with the sham-operated group.No significant difference was found between RSM-treated and sham-operated groups.The preliminaryresults suggest that VIP may be involved in thepathophysiological procedures of cerebral ischemiaand RSM may attenuate the dysfunction of VIPduring cerebral ischemia.</description><subject>Animals</subject><subject>attenuate</subject><subject>Brain - metabolism</subject><subject>carotid</subject><subject>cortex</subject><subject>Drug Combinations - pharmacology</subject><subject>Drug Combinations - therapeutic use</subject><subject>Drugs, Chinese Herbal</subject><subject>hippocampus</subject><subject>Ischemic Attack, Transient - drug therapy</subject><subject>Ischemic Attack, Transient - metabolism</subject><subject>ligation</subject><subject>Male</subject><subject>nucleus</subject><subject>operated</subject><subject>Phenanthrolines - pharmacology</subject><subject>Phenanthrolines - therapeutic use</subject><subject>Plant Extracts</subject><subject>Radix</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>saline</subject><subject>vasoactive</subject><subject>Vasoactive Intestinal Peptide - metabolism</subject><issn>0255-2922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMlqwzAURbVoSdO0n1AQFLozyLImd6c6ci3wEGwRQjdGntKUzE4W_fs6JHT13jv38Bb3DowRptTBPsYP4LHvfxCiglIxAiPMXEqoGIOTiRRUYagCA7MQ5nKqF7CQ8VxLBRMdG53leaS_hitL4VwWmQyMniuoU6MKo1MZw5maGT29IBioXH3kA9NFEKlEy3eZQpnqZEBqMVO5TlRqnsB9Z9d9-3ybE2BCZYLIibNPHcjYqYUrnK5raF2RqmKIi8vKmOisX7nY54JgRojfsKpzBefWw41FHWJY-JR5xFrEWm8C3q5v98fd4dz2p3Kz6ut2vbbbdnfuS-4TQjkVg_hyE8_Vpm3K_XG1scff8tbSkL9e8_p7t10eVtvlv-Ih5BJCXMa9P2LBY6k</recordid><startdate>198909</startdate><enddate>198909</enddate><creator>匡培根 吴卫平 张凤英 刘洁晓 蒲传强</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198909</creationdate><title>THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON VASOACTIVE INTESTINAL PEPTIDE IN CEREBRAL ISCHEMIA:AN ANIMAL EXPERIMENT</title><author>匡培根 吴卫平 张凤英 刘洁晓 蒲传强</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c818-ffd5cb4bb6078d5cb668fa9b12978426449d6bf1877a32da0f062895634aa06e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>attenuate</topic><topic>Brain - metabolism</topic><topic>carotid</topic><topic>cortex</topic><topic>Drug Combinations - pharmacology</topic><topic>Drug Combinations - therapeutic use</topic><topic>Drugs, Chinese Herbal</topic><topic>hippocampus</topic><topic>Ischemic Attack, Transient - drug therapy</topic><topic>Ischemic Attack, Transient - metabolism</topic><topic>ligation</topic><topic>Male</topic><topic>nucleus</topic><topic>operated</topic><topic>Phenanthrolines - pharmacology</topic><topic>Phenanthrolines - therapeutic use</topic><topic>Plant Extracts</topic><topic>Radix</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>saline</topic><topic>vasoactive</topic><topic>Vasoactive Intestinal Peptide - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>匡培根 吴卫平 张凤英 刘洁晓 蒲传强</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of traditional Chinese medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>匡培根 吴卫平 张凤英 刘洁晓 蒲传强</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON VASOACTIVE INTESTINAL PEPTIDE IN CEREBRAL ISCHEMIA:AN ANIMAL EXPERIMENT</atitle><jtitle>Journal of traditional Chinese medicine</jtitle><addtitle>Journal of Traditional Chinese Medicine</addtitle><date>1989-09</date><risdate>1989</risdate><volume>9</volume><issue>3</issue><spage>203</spage><epage>206</epage><pages>203-206</pages><issn>0255-2922</issn><abstract>The levels of vasoactive intestinal peptide(VIP)in three regions of rat brain were assayed in 62 rats.Bilateral common carotid artery ligation was donein 50 rats.Half an hour before ligation 26 rats weregiven 10 g/kg of Radix Salviae Miltiorrhizae(RSM);24 rats were given same volume of normalsaline as controls.A sham operation wasdone in 12 rats.Half an hour(n=30)and 3hours(n=32)after operation,the rats were quicklydecapitated.VIP levels were assayed in cerebralcortex,hippocampus and caudate nucleus,in salin-treated animals,VIP levels of cerebral cortex andcaudate nucleus at 3 hour group were significantlydecreased compared with the sham-operated group.No significant difference was found between RSM-treated and sham-operated groups.The preliminaryresults suggest that VIP may be involved in thepathophysiological procedures of cerebral ischemiaand RSM may attenuate the dysfunction of VIPduring cerebral ischemia.</abstract><cop>China</cop><pmid>2615458</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Journal of traditional Chinese medicine, 1989-09, Vol.9 (3), p.203-206 |
| issn | 0255-2922 |
| language | eng |
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| subjects | Animals attenuate Brain - metabolism carotid cortex Drug Combinations - pharmacology Drug Combinations - therapeutic use Drugs, Chinese Herbal hippocampus Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - metabolism ligation Male nucleus operated Phenanthrolines - pharmacology Phenanthrolines - therapeutic use Plant Extracts Radix Rats Rats, Inbred Strains saline vasoactive Vasoactive Intestinal Peptide - metabolism |
| title | THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON VASOACTIVE INTESTINAL PEPTIDE IN CEREBRAL ISCHEMIA:AN ANIMAL EXPERIMENT |
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